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- W2095533089 abstract "As in the case of phosphofructokinases from a number of other tissues and organisms, inhibition of phosphofructokinase (PFK) activity of Schistosoma mansoni by high concentrations of ATP is increased by citrate; it is reduced by raising the concentration of fructose 6-phosphate (F6P), and, in varying degrees, by adenosine monophosphate, adenosine diphosphate, cyclic 3′, 5′-adenosine monophosphate, inorganic phosphate, and ammonium and sulfate ions. Evidence is reported indicating that ATP decreases the affinity of schistosome PFK for F6P and that those compounds which reverse the inhibitory effect of high ATP concentrations increase the affinity of the enzyme for F6P. Several differences between the properties of mammalian phosphofructokinases and those of the schitosome enzyme are noted, one of which consists in a 65 to 80 times higher sensitivity of schistosome PFK to the inhibitory effects of trivalent organic antimonials. Inhibition of the activity of this enzyme by antimonials is reversed by increased concentrations of F6P; it is enhanced by high concentrations of ATP and is reduced by the same ions that increase the affinity of schistosome PFK for F6P and reduce the inhibition of enzymatic activity by ATP. It appears that antimonials exert their inhibitory effect on schistosome PFK by a reversible interaction with an F6P site of the enzyme, possibly the substrate site, and a displacement of F6P from this site. A close association between the reversible chemotherapeutic effects of trivalent organic antimonials in experimental schistosomiasis and reversible changes in the phosphate ester levels of the parasite has been observed, providing additional evidence for the causal relationship between the inhibition of schistosome PFK activity and the antichistosomal action of trivalent organic antimonials in vivo." @default.
- W2095533089 created "2016-06-24" @default.
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- W2095533089 date "1966-08-01" @default.
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- W2095533089 title "Factors affecting the inhibition of phosphofructokinase activity of Schistosoma mansoni by trivalent organic antimonials" @default.
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- W2095533089 doi "https://doi.org/10.1016/0006-2952(66)90285-1" @default.
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