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- W2095536208 abstract "RATIONALE: A multitude of closely or more distantly related allergens from a limited number of protein families have become available as recombinant allergens during recent years. In the interest of enabling cost-efficiency and standardization in IgE-based diagnostics with this type of reagent, selection of appropriate sets of allergens representing those protein families is desirable. In the design of reagent panels with minimal redundancy but preserved uniqueness, diagnostic equivalence between similar allergens needs to be assessed on evidence beyond sequence similarity or demonstration of cross-reactivity for selected patients' IgE antibodies. METHODS: Experimental ImmunoCAP tests were used to measure specific IgE antibody binding to recombinant allergens from cherry, peach, hazelnut, apple, pear, celery, carrot, peanut and soybean in serum samples collected in different clinical studies on allergy to these foods. The allergen families studied were PR-10 (11 allergens), ns-LTP (5 allergens) and profilin (7 allergens). RESULTS: Measurements of IgE binding to members of the 3 allergen families were compared in a pairwise fashion to assess global epitope similarity within each family. High levels of IgE binding similarity was observed among members of the profilin and ns-LTP families while significant diversity was found within the PR-10 family. In order to objectively assess immunological similarity between related allergens, a simple Allergen Similarity Index (ASI) was devised which takes into account both correlation of compared datasets and level of IgE binding. CONCLUSIONS: An evidence-based, objective measure of allergen similarity was devised which supports interchangeability of several of the allergens tested and illustrates the unique and irreplaceable nature of others." @default.
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- W2095536208 date "2007-01-01" @default.
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- W2095536208 title "An Objective Approach for the Assessment of Interchangeability of Cross-Reactive Food Allergens in Diagnostic Tests for Specific IgE" @default.
- W2095536208 doi "https://doi.org/10.1016/j.jaci.2006.12.127" @default.
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