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• W2095553313 abstract "Granulosa cell tumours (GCT) are rare sex cord stromal tumour, encompassing only 2% of all the ovarian tumours [1]. Only 0.1% of all ovarian tumours and 4-5% of GCT occur in children. Juvenile GCT a subtype of ovarian sex cord stromal tumour has a favorable prognosis if diagnosed at an early stage. In view of uncommon gynecological malignancy and to preserve the fertility, histological examination of the resected specimen always warranted with expertise.A 2-year-old girl presented to surgical department with chief complains of abdominal distension since one month and abdominal pain on left side since eight days. There was no history of associated nausea and vomiting or vaginal bleeding. Physical examination showed abdominal mass over the left side measuring 8x6 cms. Abdominal USG revealed 10x8 cm well defined solid lesion in umbilical and infraumbilical region. Right sided adnexa were unremarkable. In view of clinical diagnosis of ovarian tumour exploratory laprotomy was done and oopherectomy specimen was sent for histopathology. The specimen measuring 11x9x6cms with attached tiny fimbrial end of tube. External surface was well circumscribed, globular, and smooth with congested blood vessels. On cutting open- well encapsulated homogenous solid grey white tumour mass measuring 9x8x5cm noted replacing the entire ovarian tissue with focal tiny cystic areas. Sections studied shows tumour cells are arranged in sheets, nodules, macro and microfollicles, trabeculae and tubules [Table/Fig-1]. The individual tumour cells are small, round to oval with mild pleomorphic hyperchromic to vesicular nuclei with occasional prominent nucleoli having moderate eosinophilic to vacuolated cytoplasm [Table/Fig-2]. Occasional call exner bodies and tumour cells with grooved nuclei were noted. The tumour cells are separated by fibro-the comatous stroma of spindle cells. Occasional mitosis figures are noted. Immunohistochemically proved as JGCT in view of diffuse immunoreactivity for Calretinin and focally for Inhibin, CD 99 and immunonegative for Alpha fetoprotein [Table/Fig-3]. Final histopathological diagnosis given as juvenile granulosa cell tumour of left ovary.[Table/Fig-1]:Light microscopy showed well circumscribed tumour with tumour cells arranged follicular and various patterns. (H &E stain)[Table/Fig-2]:Light microscopy showed well circumscribed tumour with tumour cells arranged in follicular and various patterns (H& E, x100)[Table/Fig-3]:The tumour cells show diffuse immunoreactivity for Calretinin with focal positive for inhibin, CD 99 and negative for alpha fetoproteinMost of the juvenile GCTs presented with clinical evidence of precocious pseudo puberty including breast development, pubic and axillary hairs, vaginal secretions, irregular uterine bleeding and other secondary sexual characteristics [2]. However, our case was free from such symptoms and her presentation was abdominal pain and distension.GCT of ovary was first described in 1985 by Rokitansky. Juvenile GCT differs from the adult [3].GCT that is seen in older females with respect to the clinical and pathological features as well as biological behaviour [4]. The positive immunohistochemical stain for inhibin, an ovarian glycoprotein is a key diagnostic feature along with calretinin, CD 99 and FOXL2 [5].Granulosa cell tumour is a rare neoplasm of different behaviour. In addition to its rarity in childhood, the presented case is of particular interest for having abdominal pain and distension only without any secondary sexual characteristics. Histopathological diagnosis requires a great deal of expertise in view of age, treatment modalities and prognosis as this tumour differs from other ovarian tumours. IHC markers may be prognostically helpful in this rare condition." @default.
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• W2095553313 date "2014-01-01" @default.
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• W2095553313 title "Ovarian Juvenile Granulosa Cell Tumour in Childhood: Uncommon Gynecological Malignancy" @default.
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• W2095553313 doi "https://doi.org/10.7860/jcdr/2014/9510.4935" @default.
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