FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095589863> ?p ?o ?g. }

• W2095589863 endingPage "8333" @default.
• W2095589863 startingPage "8323" @default.
• W2095589863 abstract "To elucidate the physiological role(s) of DUSP9 (dual-specificity phosphatase 9), also known as MKP-4 (mitogen-activated protein kinase [MAPK] phosphatase 4), the gene was deleted in mice. Crossing male chimeras with wild-type females resulted in heterozygous (DUSP9+/−) females. However, when these animals were crossed with wild-type (DUSP9+/y) males none of the progeny carried the targeted DUSP9 allele, indicating that both female heterozygous and male null (DUSP9−/y) animals die in utero. The DUSP9 gene is on the X chromosome, and this pattern of embryonic lethality is consistent with the selective inactivation of the paternal X chromosome in the extraembryonic tissues of the mouse, suggesting that DUSP9/MKP4 performs an essential function during placental development. Examination of embryos between 8 and 10.5 days postcoitum confirmed that lethality was due to a failure of labyrinth development, and this correlates exactly with the normal expression pattern of DUSP9/MKP-4 in the trophoblast giant cells and labyrinth of the placenta. Finally, when the placental defect was rescued, male null (DUSP9−/y) embryos developed to term, appeared normal, and were fertile. Our results indicate that DUSP9/MKP-4 is essential for placental organogenesis but is otherwise dispensable for mammalian embryonic development and highlights the critical role of dual-specificity MAPK phosphatases in the regulation of developmental outcomes in vertebrates." @default.
• W2095589863 created "2016-06-24" @default.
• W2095589863 creator A5003505599 @default.
• W2095589863 creator A5033321035 @default.
• W2095589863 creator A5043928379 @default.
• W2095589863 creator A5050612636 @default.
• W2095589863 creator A5073066475 @default.
• W2095589863 creator A5091622396 @default.
• W2095589863 date "2005-09-01" @default.
• W2095589863 modified "2023-09-24" @default.
• W2095589863 title "The Dual-Specificity Protein Phosphatase DUSP9/MKP-4 Is Essential for Placental Function but Is Not Required for Normal Embryonic Development" @default.
• W2095589863 cites W14552048 @default.
• W2095589863 cites W1532341958 @default.
• W2095589863 cites W1597498191 @default.
• W2095589863 cites W1960824264 @default.
• W2095589863 cites W1967071065 @default.
• W2095589863 cites W1970508192 @default.
• W2095589863 cites W1974347350 @default.
• W2095589863 cites W1975751233 @default.
• W2095589863 cites W1975974673 @default.
• W2095589863 cites W1984945589 @default.
• W2095589863 cites W1993928278 @default.
• W2095589863 cites W1996051231 @default.
• W2095589863 cites W2000525981 @default.
• W2095589863 cites W2002468669 @default.
• W2095589863 cites W2015129765 @default.
• W2095589863 cites W2020184457 @default.
• W2095589863 cites W2021122622 @default.
• W2095589863 cites W2026430445 @default.
• W2095589863 cites W2032711371 @default.
• W2095589863 cites W2033698470 @default.
• W2095589863 cites W2045744965 @default.
• W2095589863 cites W2051541090 @default.
• W2095589863 cites W2074345277 @default.
• W2095589863 cites W2075832020 @default.
• W2095589863 cites W2080748329 @default.
• W2095589863 cites W2081599782 @default.
• W2095589863 cites W2083076387 @default.
• W2095589863 cites W2097783992 @default.
• W2095589863 cites W2100774604 @default.
• W2095589863 cites W2101325866 @default.
• W2095589863 cites W2111305451 @default.
• W2095589863 cites W2119670701 @default.
• W2095589863 cites W2123887022 @default.
• W2095589863 cites W2149884899 @default.
• W2095589863 doi "https://doi.org/10.1128/mcb.25.18.8323-8333.2005" @default.
• W2095589863 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1234323" @default.
• W2095589863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16135819" @default.
• W2095589863 hasPublicationYear "2005" @default.
• W2095589863 type Work @default.
• W2095589863 sameAs 2095589863 @default.
• W2095589863 citedByCount "65" @default.
• W2095589863 countsByYear W20955898632012 @default.
• W2095589863 countsByYear W20955898632013 @default.
• W2095589863 countsByYear W20955898632014 @default.
• W2095589863 countsByYear W20955898632015 @default.
• W2095589863 countsByYear W20955898632016 @default.
• W2095589863 countsByYear W20955898632017 @default.
• W2095589863 countsByYear W20955898632019 @default.
• W2095589863 countsByYear W20955898632020 @default.
• W2095589863 countsByYear W20955898632021 @default.
• W2095589863 countsByYear W20955898632022 @default.
• W2095589863 countsByYear W20955898632023 @default.
• W2095589863 crossrefType "journal-article" @default.
• W2095589863 hasAuthorship W2095589863A5003505599 @default.
• W2095589863 hasAuthorship W2095589863A5033321035 @default.
• W2095589863 hasAuthorship W2095589863A5043928379 @default.
• W2095589863 hasAuthorship W2095589863A5050612636 @default.
• W2095589863 hasAuthorship W2095589863A5073066475 @default.
• W2095589863 hasAuthorship W2095589863A5091622396 @default.
• W2095589863 hasBestOaLocation W20955898631 @default.
• W2095589863 hasConcept C104317684 @default.
• W2095589863 hasConcept C11960822 @default.
• W2095589863 hasConcept C145103041 @default.
• W2095589863 hasConcept C153911025 @default.
• W2095589863 hasConcept C172680121 @default.
• W2095589863 hasConcept C178666793 @default.
• W2095589863 hasConcept C180754005 @default.
• W2095589863 hasConcept C184235292 @default.
• W2095589863 hasConcept C196843134 @default.
• W2095589863 hasConcept C2776953305 @default.
• W2095589863 hasConcept C2777495146 @default.
• W2095589863 hasConcept C2779234561 @default.
• W2095589863 hasConcept C2780429522 @default.
• W2095589863 hasConcept C54355233 @default.
• W2095589863 hasConcept C57074206 @default.
• W2095589863 hasConcept C57708383 @default.
• W2095589863 hasConcept C86803240 @default.
• W2095589863 hasConcept C87073359 @default.
• W2095589863 hasConcept C95444343 @default.
• W2095589863 hasConceptScore W2095589863C104317684 @default.
• W2095589863 hasConceptScore W2095589863C11960822 @default.
• W2095589863 hasConceptScore W2095589863C145103041 @default.
• W2095589863 hasConceptScore W2095589863C153911025 @default.
• W2095589863 hasConceptScore W2095589863C172680121 @default.
• W2095589863 hasConceptScore W2095589863C178666793 @default.
• W2095589863 hasConceptScore W2095589863C180754005 @default.
• W2095589863 hasConceptScore W2095589863C184235292 @default.

• next