Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095600570> ?p ?o ?g. }
- W2095600570 endingPage "143" @default.
- W2095600570 startingPage "130" @default.
- W2095600570 abstract "In this work, we introduce alcohol-free lecithin microemulsions formulated with linkers to produce transdermal delivery vehicles. The food-grade linker system consists of a combination of sodium caprylate and caprylic acid (hydrophilic linkers), and sorbitan monooleate (lipophilic linker). A “carrier” oil (isopropyl myristate) was used to predissolve a model lipophilic drug, lidocaine. The first part of the article describes the phase behavior and physical properties of these linker-based lecithin microemulsions. In the second part of the article, we evaluate the transdermal permeation and cytotoxicity of lidocaine formulated in oil-in-water (Type I), water-in-oil (Type II), and bicontinuous (Type IV) linker microemulsions. The transdermal permeation studies show that compared to a conventional Type II alcohol-based lecithin microemulsion, Type II linker-based microemulsions provide twice the absorption and penetration of lidocaine through skin. The larger flux obtained with linker systems is due to the presence of sodium caprylate and caprylic acid. These hydrophilic linkers accelerate the microemulsion-skin mass transfer by reducing the interfacial rigidity of the systems. Furthermore, the cytotoxicity studies show that these linker microemulsions are significantly less toxic than the alcohol-based system. The Type II linker microemulsion (containing approximately 4% lidocaine) has a comparable cytotoxicity to water saturated with lidocaine (0.4% lidocaine)." @default.
- W2095600570 created "2016-06-24" @default.
- W2095600570 creator A5038115898 @default.
- W2095600570 creator A5054053853 @default.
- W2095600570 creator A5056656883 @default.
- W2095600570 creator A5073237133 @default.
- W2095600570 date "2008-02-12" @default.
- W2095600570 modified "2023-10-17" @default.
- W2095600570 title "Linker-based lecithin microemulsions for transdermal delivery of lidocaine" @default.
- W2095600570 cites W14432301 @default.
- W2095600570 cites W1480562807 @default.
- W2095600570 cites W1482341134 @default.
- W2095600570 cites W1526629922 @default.
- W2095600570 cites W1571332264 @default.
- W2095600570 cites W1573102918 @default.
- W2095600570 cites W1964118137 @default.
- W2095600570 cites W1966104273 @default.
- W2095600570 cites W1966414508 @default.
- W2095600570 cites W1966740532 @default.
- W2095600570 cites W1974165090 @default.
- W2095600570 cites W1977955109 @default.
- W2095600570 cites W1981805168 @default.
- W2095600570 cites W1982209838 @default.
- W2095600570 cites W1987447189 @default.
- W2095600570 cites W1989874279 @default.
- W2095600570 cites W1993615662 @default.
- W2095600570 cites W1996823721 @default.
- W2095600570 cites W1998339940 @default.
- W2095600570 cites W2008526663 @default.
- W2095600570 cites W2016746452 @default.
- W2095600570 cites W2020558918 @default.
- W2095600570 cites W2020908016 @default.
- W2095600570 cites W2021562517 @default.
- W2095600570 cites W2024409040 @default.
- W2095600570 cites W2028736491 @default.
- W2095600570 cites W2029366081 @default.
- W2095600570 cites W2030669855 @default.
- W2095600570 cites W2034496890 @default.
- W2095600570 cites W2045557636 @default.
- W2095600570 cites W2047213593 @default.
- W2095600570 cites W2052572695 @default.
- W2095600570 cites W2053233427 @default.
- W2095600570 cites W2056122896 @default.
- W2095600570 cites W2056406407 @default.
- W2095600570 cites W2058350479 @default.
- W2095600570 cites W2070899735 @default.
- W2095600570 cites W2071831898 @default.
- W2095600570 cites W2072071529 @default.
- W2095600570 cites W2075400410 @default.
- W2095600570 cites W2075496018 @default.
- W2095600570 cites W2079160242 @default.
- W2095600570 cites W2080768357 @default.
- W2095600570 cites W2090100100 @default.
- W2095600570 cites W2095295524 @default.
- W2095600570 cites W2100520064 @default.
- W2095600570 cites W2132905138 @default.
- W2095600570 cites W2172187417 @default.
- W2095600570 cites W2271908093 @default.
- W2095600570 cites W2499855170 @default.
- W2095600570 cites W607052793 @default.
- W2095600570 cites W608681542 @default.
- W2095600570 cites W617506740 @default.
- W2095600570 cites W629297161 @default.
- W2095600570 cites W166085445 @default.
- W2095600570 cites W2019796793 @default.
- W2095600570 cites W2129360365 @default.
- W2095600570 doi "https://doi.org/10.1016/j.ijpharm.2007.07.047" @default.
- W2095600570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17904775" @default.
- W2095600570 hasPublicationYear "2008" @default.
- W2095600570 type Work @default.
- W2095600570 sameAs 2095600570 @default.
- W2095600570 citedByCount "107" @default.
- W2095600570 countsByYear W20956005702012 @default.
- W2095600570 countsByYear W20956005702013 @default.
- W2095600570 countsByYear W20956005702014 @default.
- W2095600570 countsByYear W20956005702015 @default.
- W2095600570 countsByYear W20956005702016 @default.
- W2095600570 countsByYear W20956005702017 @default.
- W2095600570 countsByYear W20956005702018 @default.
- W2095600570 countsByYear W20956005702019 @default.
- W2095600570 countsByYear W20956005702020 @default.
- W2095600570 countsByYear W20956005702021 @default.
- W2095600570 countsByYear W20956005702022 @default.
- W2095600570 countsByYear W20956005702023 @default.
- W2095600570 crossrefType "journal-article" @default.
- W2095600570 hasAuthorship W2095600570A5038115898 @default.
- W2095600570 hasAuthorship W2095600570A5054053853 @default.
- W2095600570 hasAuthorship W2095600570A5056656883 @default.
- W2095600570 hasAuthorship W2095600570A5073237133 @default.
- W2095600570 hasConcept C111919701 @default.
- W2095600570 hasConcept C178790620 @default.
- W2095600570 hasConcept C185592680 @default.
- W2095600570 hasConcept C190119865 @default.
- W2095600570 hasConcept C205679159 @default.
- W2095600570 hasConcept C2775850501 @default.
- W2095600570 hasConcept C2779564620 @default.
- W2095600570 hasConcept C2779783494 @default.
- W2095600570 hasConcept C2780557392 @default.