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- W2095608230 abstract "Background: Valproic acid (VPA) is an anticonvulsant drug used for the treatment of epilepsy and bipolar disorder. A method based on simultaneous derivatization and dispersive liquid–liquid microextraction followed by GC–MS/MS analysis has been developed for the determination of VPA in urine samples. Results: This optimized and validated method shows good linearity with R 2 value of 0.999. LOD and LOQ of VPA was found to be 0.4 ng ml -1 and 1.4 ng ml -1 , respectively. Recovery of VPA was found to be in the range of 80 to 92%. Conclusion: The developed method can find its wide applicability for the routine analysis of VPA in toxicological and clinical laboratories." @default.
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- W2095608230 date "2015-10-01" @default.
- W2095608230 modified "2023-09-23" @default.
- W2095608230 title "Ultrasound-assisted dispersive liquid–liquid microextraction followed by GC–MS/MS analysis for the determination of valproic acid in urine samples" @default.
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- W2095608230 doi "https://doi.org/10.4155/bio.15.162" @default.
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