FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095609357> ?p ?o ?g. }

• W2095609357 endingPage "362" @default.
• W2095609357 startingPage "351" @default.
• W2095609357 abstract "Pituicyte stellation in vitro represents a useful model with which to study morphological changes that occur in vivo in these cells during times of high neurohypophysial hormone output. This model has helped us establish the hypothesis of a purinergic regulation of pituicyte morphological plasticity. We first show that ATP induces stellation in 37% of pituicytes, an effect that is secondary to the metabolism of ATP to adenosine. Adenosine-induced stellation of pituicytes appears to be mediated by A(1)-type receptors. The effect is independent of intracellular calcium and does not involve the mitogen-activated protein kinase pathway. The basal (nonstellate) state of pituicytes depends on tonic activation of a Rho GTPase because both C3 transferase (a Rho inhibitor) and Y-27632 (an inhibitor of p160Rho kinase) can induce stellation. Lysophosphatidic acid, a Rho activator, blocks the morphogenic effect of adenosine dose-dependently. Using a specific RhoA pull-down assay, we also show that downregulation of activated RhoA is the key event coupling A(1) receptor activation to pituicyte stellation, via F-actin depolymerization and microtubule reorganization. Finally, both vasopressin and oxytocin can prevent or reverse adenosine-induced stellation. The effects of vasopressin, and those of high concentrations of oxytocin, are mediated through V(1a) receptors. Placed within the context of the relevant literature, our data suggest the possibility of a purinergic regulation of pituicyte morphological plasticity and subsequent modulation of hormone release, with these hormones providing a negative feedback mechanism." @default.
• W2095609357 created "2016-06-24" @default.
• W2095609357 creator A5023381438 @default.
• W2095609357 creator A5046085675 @default.
• W2095609357 creator A5052587425 @default.
• W2095609357 creator A5053341553 @default.
• W2095609357 creator A5061058802 @default.
• W2095609357 creator A5079416840 @default.
• W2095609357 creator A5081299743 @default.
• W2095609357 creator A5085324416 @default.
• W2095609357 date "2002-04-22" @default.
• W2095609357 modified "2023-10-17" @default.
• W2095609357 title "RhoA inhibition is a key step in pituicyte stellation induced by A₁-type adenosine receptor activation" @default.
• W2095609357 cites W1236053900 @default.
• W2095609357 cites W129191972 @default.
• W2095609357 cites W1597787921 @default.
• W2095609357 cites W1845024144 @default.
• W2095609357 cites W1936552673 @default.
• W2095609357 cites W1965734619 @default.
• W2095609357 cites W1974836258 @default.
• W2095609357 cites W1975731777 @default.
• W2095609357 cites W1983233768 @default.
• W2095609357 cites W1988092837 @default.
• W2095609357 cites W1990946818 @default.
• W2095609357 cites W1997990428 @default.
• W2095609357 cites W1999771185 @default.
• W2095609357 cites W2007732337 @default.
• W2095609357 cites W2017783388 @default.
• W2095609357 cites W2018287303 @default.
• W2095609357 cites W2022951796 @default.
• W2095609357 cites W2026697636 @default.
• W2095609357 cites W2030125834 @default.
• W2095609357 cites W2050196003 @default.
• W2095609357 cites W2073830624 @default.
• W2095609357 cites W2073887706 @default.
• W2095609357 cites W2077044829 @default.
• W2095609357 cites W2088261136 @default.
• W2095609357 cites W2092811589 @default.
• W2095609357 cites W2114137017 @default.
• W2095609357 cites W2115000129 @default.
• W2095609357 cites W2130172628 @default.
• W2095609357 cites W2142245128 @default.
• W2095609357 cites W2142501862 @default.
• W2095609357 cites W2152396875 @default.
• W2095609357 cites W2157641942 @default.
• W2095609357 doi "https://doi.org/10.1002/glia.10072" @default.
• W2095609357 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12007147" @default.
• W2095609357 hasPublicationYear "2002" @default.
• W2095609357 type Work @default.
• W2095609357 sameAs 2095609357 @default.
• W2095609357 citedByCount "36" @default.
• W2095609357 countsByYear W20956093572012 @default.
• W2095609357 countsByYear W20956093572013 @default.
• W2095609357 countsByYear W20956093572014 @default.
• W2095609357 countsByYear W20956093572015 @default.
• W2095609357 countsByYear W20956093572017 @default.
• W2095609357 countsByYear W20956093572021 @default.
• W2095609357 crossrefType "journal-article" @default.
• W2095609357 hasAuthorship W2095609357A5023381438 @default.
• W2095609357 hasAuthorship W2095609357A5046085675 @default.
• W2095609357 hasAuthorship W2095609357A5052587425 @default.
• W2095609357 hasAuthorship W2095609357A5053341553 @default.
• W2095609357 hasAuthorship W2095609357A5061058802 @default.
• W2095609357 hasAuthorship W2095609357A5079416840 @default.
• W2095609357 hasAuthorship W2095609357A5081299743 @default.
• W2095609357 hasAuthorship W2095609357A5085324416 @default.
• W2095609357 hasBestOaLocation W20956093572 @default.
• W2095609357 hasConcept C134018914 @default.
• W2095609357 hasConcept C170493617 @default.
• W2095609357 hasConcept C172590197 @default.
• W2095609357 hasConcept C2776991684 @default.
• W2095609357 hasConcept C2777093181 @default.
• W2095609357 hasConcept C2778938600 @default.
• W2095609357 hasConcept C55493867 @default.
• W2095609357 hasConcept C57306754 @default.
• W2095609357 hasConcept C62478195 @default.
• W2095609357 hasConcept C67907053 @default.
• W2095609357 hasConcept C86803240 @default.
• W2095609357 hasConcept C88045685 @default.
• W2095609357 hasConcept C95444343 @default.
• W2095609357 hasConceptScore W2095609357C134018914 @default.
• W2095609357 hasConceptScore W2095609357C170493617 @default.
• W2095609357 hasConceptScore W2095609357C172590197 @default.
• W2095609357 hasConceptScore W2095609357C2776991684 @default.
• W2095609357 hasConceptScore W2095609357C2777093181 @default.
• W2095609357 hasConceptScore W2095609357C2778938600 @default.
• W2095609357 hasConceptScore W2095609357C55493867 @default.
• W2095609357 hasConceptScore W2095609357C57306754 @default.
• W2095609357 hasConceptScore W2095609357C62478195 @default.
• W2095609357 hasConceptScore W2095609357C67907053 @default.
• W2095609357 hasConceptScore W2095609357C86803240 @default.
• W2095609357 hasConceptScore W2095609357C88045685 @default.
• W2095609357 hasConceptScore W2095609357C95444343 @default.
• W2095609357 hasIssue "4" @default.
• W2095609357 hasLocation W20956093571 @default.
• W2095609357 hasLocation W20956093572 @default.
• W2095609357 hasLocation W20956093573 @default.
• W2095609357 hasOpenAccess W2095609357 @default.

• next