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- W2095611398 abstract "Borrelia burgdorferi, the cause of Lymedisease, has two major outer-membrane proteins, OspA and OspB, which act as surface antigens. A 49-kilobase linear plasmid contains the genes that encode for these surface proteins. Direct examination of denatured plasmid molecules has revealed single-stranded circles with a circumference of ∼l00 kilobases (about twice the length of the linear duplex molecule), a finding that indicates the plasmid strands have covalently closed ends. This form of DNA, while present in eukaryotic organisms and their viruses, has not been observed in a prokaryotic organism. Plasmid heterogeneityhas been observed in strains with surface proteins of similar molecular weights and similar monoclonal antibody reactivity. Thus, plasmid analysis may prove a sensitive tool for differentiating strains of B. burgdorferi. Furthermore, since loss of plasmids in vitro has been correlated with loss of the ability of many-passaged strains to cause infection, borrelial plasmids may encode for virulence factors as well." @default.
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- W2095611398 date "1989-09-01" @default.
- W2095611398 modified "2023-09-23" @default.
- W2095611398 title "The Molecular Biology of Borrelia" @default.
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- W2095611398 doi "https://doi.org/10.1093/clinids/11.supplement_6.s1470" @default.
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