FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095612117> ?p ?o ?g. }

• W2095612117 endingPage "2659" @default.
• W2095612117 startingPage "2647" @default.
• W2095612117 abstract "The trend toward personalized management of diabetes has focused attention on the differences among available pharmacological agents in terms of mechanisms of action, efficacy, and, most important, safety. Clinicians must select from these features to develop individualized therapy regimens. In June 2013, a nine-member Diabetes Care Editors' Expert Forum convened to review safety evidence for six major diabetes drug classes: insulin, sulfonylureas (SUs), thiazolidinediones (TZDs), glucagon-like peptide-1 receptor agonists, dipeptidyl peptidase-4 inhibitors, and sodium glucose cotransporter 2 inhibitors. This article, an outgrowth of the forum, summarizes well-delineated and theoretical safety concerns related to these drug classes, as well as the panelists' opinions regarding their best use in patients with type 2 diabetes. All of the options appear to have reasonably wide safety margins when used appropriately. Those about which we know the most-metformin, SUs, insulin, and perhaps now also TZDs-are efficacious in most patients and can be placed into a basic initial algorithm. However, these agents leave some clinical needs unmet. Selecting next steps is a more formidable process involving newer agents that are understood less well and for which there are unresolved questions regarding risk versus benefit in certain populations. Choosing a specific agent is not as important as implementing some form of early intervention and advancing rapidly to some form of combination therapy as needed. When all options are relatively safe given the benefits they confer, therapeutic decision making must rely on a personalized approach, taking into account patients' clinical circumstances, phenotype, pathophysiological defects, preferences, abilities, and costs." @default.
• W2095612117 created "2016-06-24" @default.
• W2095612117 creator A5034383160 @default.
• W2095612117 creator A5040182038 @default.
• W2095612117 creator A5045489578 @default.
• W2095612117 creator A5067359287 @default.
• W2095612117 creator A5070276458 @default.
• W2095612117 creator A5073517018 @default.
• W2095612117 creator A5080960032 @default.
• W2095612117 creator A5086589108 @default.
• W2095612117 creator A5087844534 @default.
• W2095612117 date "2014-08-07" @default.
• W2095612117 modified "2023-10-14" @default.
• W2095612117 title "Beyond Metformin: Safety Considerations in the Decision-Making Process for Selecting a Second Medication for Type 2 Diabetes Management" @default.
• W2095612117 cites W1526927233 @default.
• W2095612117 cites W1565699562 @default.
• W2095612117 cites W1585447752 @default.
• W2095612117 cites W1970638723 @default.
• W2095612117 cites W1971471384 @default.
• W2095612117 cites W1971540233 @default.
• W2095612117 cites W1973560276 @default.
• W2095612117 cites W1974012256 @default.
• W2095612117 cites W1975663485 @default.
• W2095612117 cites W1981183973 @default.
• W2095612117 cites W1983380435 @default.
• W2095612117 cites W1984635549 @default.
• W2095612117 cites W1984740259 @default.
• W2095612117 cites W1985739127 @default.
• W2095612117 cites W1986085856 @default.
• W2095612117 cites W1997214455 @default.
• W2095612117 cites W1997416444 @default.
• W2095612117 cites W1999882705 @default.
• W2095612117 cites W2000047428 @default.
• W2095612117 cites W2000074754 @default.
• W2095612117 cites W2004409542 @default.
• W2095612117 cites W2005075630 @default.
• W2095612117 cites W2005868272 @default.
• W2095612117 cites W2009425133 @default.
• W2095612117 cites W2009944328 @default.
• W2095612117 cites W2013920037 @default.
• W2095612117 cites W2014346836 @default.
• W2095612117 cites W2020030439 @default.
• W2095612117 cites W2026106035 @default.
• W2095612117 cites W2026969451 @default.
• W2095612117 cites W2029816181 @default.
• W2095612117 cites W2030852056 @default.
• W2095612117 cites W2031771762 @default.
• W2095612117 cites W2032322539 @default.
• W2095612117 cites W2039741453 @default.
• W2095612117 cites W2043269192 @default.
• W2095612117 cites W2048728983 @default.
• W2095612117 cites W2050826565 @default.
• W2095612117 cites W2051462052 @default.
• W2095612117 cites W2054361323 @default.
• W2095612117 cites W2054925541 @default.
• W2095612117 cites W2058922633 @default.
• W2095612117 cites W2062812115 @default.
• W2095612117 cites W2064130493 @default.
• W2095612117 cites W2064437324 @default.
• W2095612117 cites W2064617441 @default.
• W2095612117 cites W2064986223 @default.
• W2095612117 cites W2071835038 @default.
• W2095612117 cites W2077109510 @default.
• W2095612117 cites W2078482750 @default.
• W2095612117 cites W2081164960 @default.
• W2095612117 cites W2081216702 @default.
• W2095612117 cites W2081276121 @default.
• W2095612117 cites W2087366614 @default.
• W2095612117 cites W2087682588 @default.
• W2095612117 cites W2088620867 @default.
• W2095612117 cites W2090816085 @default.
• W2095612117 cites W2092361523 @default.
• W2095612117 cites W2092923539 @default.
• W2095612117 cites W2094195067 @default.
• W2095612117 cites W2096539888 @default.
• W2095612117 cites W2098008729 @default.
• W2095612117 cites W2098459806 @default.
• W2095612117 cites W2099673402 @default.
• W2095612117 cites W2102052385 @default.
• W2095612117 cites W2103058881 @default.
• W2095612117 cites W2103525547 @default.
• W2095612117 cites W2105407506 @default.
• W2095612117 cites W2105575861 @default.
• W2095612117 cites W2108646121 @default.
• W2095612117 cites W2110265466 @default.
• W2095612117 cites W2111155556 @default.
• W2095612117 cites W2112981414 @default.
• W2095612117 cites W2115357902 @default.
• W2095612117 cites W2118710260 @default.
• W2095612117 cites W2119702318 @default.
• W2095612117 cites W2121264929 @default.
• W2095612117 cites W2121970519 @default.
• W2095612117 cites W2122696108 @default.
• W2095612117 cites W2127833912 @default.
• W2095612117 cites W2127854619 @default.
• W2095612117 cites W2128395400 @default.
• W2095612117 cites W2129578585 @default.
• W2095612117 cites W2130143203 @default.

• next