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- W2095621515 abstract "This review summarized evidence in support for the case that ischemia elicits an inflammatory condition in the injured brain. The inflammatory condition consists of cells (neutrophils at the onset and later monocytes) and mediators (cytokines, chemokines, others). It is clear that de novo upregulation of proinflammatory cytokines, chemokines and endothelial-leukocyte adhesion molecules in the brain follow soon after the ischemic insult and at a time when the cellular component is evolving. The significance of the inflammatory response to brain ischemia is not fully understood. Evidence is emerging in support of the possibility that the acute inflammatory reaction to brain ischemia may be causally related to brain damage. This evidence includes: 1) the capacity of cytokines to exacerbate brain damage; 2) the capacity of specific cytokine antagonists such as IL-1ra to reduce ischemic brain damage; 3) that depletion of circulating neutrophils reduces ischemic brain injury; 4) and that antagonists of the endothelial-leukocyte adhesion interactions (e.g., anti-ICAM-1) reduce ischemic brain injury. However, it should be kept in mind that cytokines were also argued to provide beneficial effects in brain injury as inferred from studies with TNF-receptor knock-out mice (p55 and p75 knock-out), which display increased sensitivity to brain ischemia, and the capacity of IL-1 to elicit the state of ischemic tolerance upon repeated administration. Nevertheless, the recent revelation on the capacity of ischemia to induce acute inflammation in the brain provides a new and fertile ground for new explorations for novel therapeutic agents that could confine the neuronal damage that follows ischemia. Furthermore, many of the genes that are upregulated by ischemia have growth-promotion capacity and therefore raise the possibility that such gene products may be useful in counteracting brain damage by enhancing repair and establishing compensatory mechanisms that enhance histological and functional recovery." @default.
- W2095621515 created "2016-06-24" @default.
- W2095621515 creator A5003026401 @default.
- W2095621515 creator A5012502619 @default.
- W2095621515 creator A5083512491 @default.
- W2095621515 date "1997-10-01" @default.
- W2095621515 modified "2023-10-10" @default.
- W2095621515 title "Inflammatory Gene Expression in Cerebral Ischemia and Trauma" @default.
- W2095621515 cites W1496877897 @default.
- W2095621515 cites W1515994079 @default.
- W2095621515 cites W1573515835 @default.
- W2095621515 cites W1577743059 @default.
- W2095621515 cites W1836407144 @default.
- W2095621515 cites W1848552725 @default.
- W2095621515 cites W1915518296 @default.
- W2095621515 cites W1915556271 @default.
- W2095621515 cites W1970334202 @default.
- W2095621515 cites W1971153516 @default.
- W2095621515 cites W1975298116 @default.
- W2095621515 cites W1976665899 @default.
- W2095621515 cites W1976887761 @default.
- W2095621515 cites W1977821697 @default.
- W2095621515 cites W1978166151 @default.
- W2095621515 cites W1978487251 @default.
- W2095621515 cites W1979090235 @default.
- W2095621515 cites W1979961027 @default.
- W2095621515 cites W1980099148 @default.
- W2095621515 cites W1980369396 @default.
- W2095621515 cites W1980793025 @default.
- W2095621515 cites W1983612328 @default.
- W2095621515 cites W1985361423 @default.
- W2095621515 cites W1987331972 @default.
- W2095621515 cites W1990711278 @default.
- W2095621515 cites W1991377288 @default.
- W2095621515 cites W1991705223 @default.
- W2095621515 cites W1995260756 @default.
- W2095621515 cites W1997255414 @default.
- W2095621515 cites W1997510003 @default.
- W2095621515 cites W1998200062 @default.
- W2095621515 cites W2003068831 @default.
- W2095621515 cites W2003525136 @default.
- W2095621515 cites W2011349107 @default.
- W2095621515 cites W2012066718 @default.
- W2095621515 cites W2015085032 @default.
- W2095621515 cites W2015384236 @default.
- W2095621515 cites W2020138738 @default.
- W2095621515 cites W2023396428 @default.
- W2095621515 cites W2024476573 @default.
- W2095621515 cites W2024906564 @default.
- W2095621515 cites W2025326202 @default.
- W2095621515 cites W2029368857 @default.
- W2095621515 cites W2029378364 @default.
- W2095621515 cites W2034827296 @default.
- W2095621515 cites W2035396253 @default.
- W2095621515 cites W2037507488 @default.
- W2095621515 cites W2038170564 @default.
- W2095621515 cites W2040671393 @default.
- W2095621515 cites W2040957577 @default.
- W2095621515 cites W2045839175 @default.
- W2095621515 cites W2046335509 @default.
- W2095621515 cites W2047480541 @default.
- W2095621515 cites W2048890514 @default.
- W2095621515 cites W2050694917 @default.
- W2095621515 cites W2052313062 @default.
- W2095621515 cites W2056230880 @default.
- W2095621515 cites W2059273327 @default.
- W2095621515 cites W2061642062 @default.
- W2095621515 cites W2063842801 @default.
- W2095621515 cites W2067051297 @default.
- W2095621515 cites W2067101458 @default.
- W2095621515 cites W2067436359 @default.
- W2095621515 cites W2069132198 @default.
- W2095621515 cites W2075154733 @default.
- W2095621515 cites W2076197577 @default.
- W2095621515 cites W2076339827 @default.
- W2095621515 cites W2078640332 @default.
- W2095621515 cites W2080562431 @default.
- W2095621515 cites W2081372125 @default.
- W2095621515 cites W2082011784 @default.
- W2095621515 cites W2082392681 @default.
- W2095621515 cites W2085547973 @default.
- W2095621515 cites W2088318869 @default.
- W2095621515 cites W2090439922 @default.
- W2095621515 cites W2091111800 @default.
- W2095621515 cites W2091394421 @default.
- W2095621515 cites W2100070617 @default.
- W2095621515 cites W2100994529 @default.
- W2095621515 cites W2104371820 @default.
- W2095621515 cites W2111471304 @default.
- W2095621515 cites W2122840791 @default.
- W2095621515 cites W2129889907 @default.
- W2095621515 cites W2131659895 @default.
- W2095621515 cites W2141239782 @default.
- W2095621515 cites W2141372702 @default.
- W2095621515 cites W2153026221 @default.
- W2095621515 cites W2167915117 @default.
- W2095621515 doi "https://doi.org/10.1111/j.1749-6632.1997.tb48428.x" @default.
- W2095621515 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9369986" @default.