Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095622015> ?p ?o ?g. }
- W2095622015 endingPage "191" @default.
- W2095622015 startingPage "181" @default.
- W2095622015 abstract "We have previously shown that co-administration of the transient osteoclast inhibitor, salmon calcitonin (sCT), blunts the anabolic effect of parathyroid hormone (PTH) in young rats and increases osteocytic expression of the bone formation inhibitor sclerostin (Sost). To determine whether this also occurs in adult animals, we co-administered sCT with PTH to 6-month-old sham-operated (SHAM) and ovariectomised (OVX) rats. While sCT reduced the stimulatory effect of PTH on serum amino-terminal propeptide of type 1 procollagen levels, in contrast to its influence in young rats, sCT did not reduce the anabolic effect of PTH on femoral bone mineral density, tibial trabecular bone volume or bone formation rate in 6-month-old SHAM or OVX rats. Quantitative real-time PCR analysis of femoral metaphyses collected 1 and 4 h after a single PTH injection confirmed a significant increase in mRNA levels for interleukin 6 (Il6) and ephrinB2 (EfnB2), and a significant reduction in Sost and dentin matrix protein-1 (Dmp1) in response to PTH. However, in contrast to observations in young rats, these effects were not modified by co-administration of sCT, nor did sCT significantly modify Sost, Dmp1, or matrix extracellular phosphoglycoprotein (Mepe) mRNA levels. Furthermore, while CT receptor (CTR) mRNA (Calcr) was readily detected in GFP+ osteocytes isolated from young (3-week-old) DMP1-GFP mice, Calcr levels in osteocytes declined as mice aged, reaching levels that were undetectable in long bone at 49 weeks of age. These data indicate that osteocyte-mediated responses to CT are most likely to be of physiological relevance in young rodents." @default.
- W2095622015 created "2016-06-24" @default.
- W2095622015 creator A5018214967 @default.
- W2095622015 creator A5020653419 @default.
- W2095622015 creator A5020882457 @default.
- W2095622015 creator A5055978192 @default.
- W2095622015 creator A5062465642 @default.
- W2095622015 creator A5074715876 @default.
- W2095622015 creator A5082442667 @default.
- W2095622015 date "2014-02-10" @default.
- W2095622015 modified "2023-10-18" @default.
- W2095622015 title "Decline in calcitonin receptor expression in osteocytes with age" @default.
- W2095622015 cites W1970867711 @default.
- W2095622015 cites W1971970997 @default.
- W2095622015 cites W1976265795 @default.
- W2095622015 cites W1983138207 @default.
- W2095622015 cites W1989880575 @default.
- W2095622015 cites W2004217766 @default.
- W2095622015 cites W2008081910 @default.
- W2095622015 cites W2011578056 @default.
- W2095622015 cites W2014732422 @default.
- W2095622015 cites W2017105628 @default.
- W2095622015 cites W2017136783 @default.
- W2095622015 cites W2022112190 @default.
- W2095622015 cites W2026387061 @default.
- W2095622015 cites W2029614230 @default.
- W2095622015 cites W2029785987 @default.
- W2095622015 cites W2032752377 @default.
- W2095622015 cites W2033951059 @default.
- W2095622015 cites W2034783705 @default.
- W2095622015 cites W2040441524 @default.
- W2095622015 cites W2041578222 @default.
- W2095622015 cites W2044264310 @default.
- W2095622015 cites W2044726772 @default.
- W2095622015 cites W2057035809 @default.
- W2095622015 cites W2058125623 @default.
- W2095622015 cites W2064628919 @default.
- W2095622015 cites W2065938534 @default.
- W2095622015 cites W2071596010 @default.
- W2095622015 cites W2085530184 @default.
- W2095622015 cites W2093595636 @default.
- W2095622015 cites W2099995240 @default.
- W2095622015 cites W2103502150 @default.
- W2095622015 cites W2108642017 @default.
- W2095622015 cites W2108998830 @default.
- W2095622015 cites W2113162921 @default.
- W2095622015 cites W2122282746 @default.
- W2095622015 cites W2143005633 @default.
- W2095622015 cites W2143975426 @default.
- W2095622015 cites W2149719379 @default.
- W2095622015 cites W2151761898 @default.
- W2095622015 cites W2157222066 @default.
- W2095622015 cites W2160364738 @default.
- W2095622015 cites W2161173985 @default.
- W2095622015 cites W2162373070 @default.
- W2095622015 cites W2163778784 @default.
- W2095622015 cites W2172203553 @default.
- W2095622015 cites W4234593192 @default.
- W2095622015 cites W4238640554 @default.
- W2095622015 cites W4242629084 @default.
- W2095622015 doi "https://doi.org/10.1530/joe-13-0524" @default.
- W2095622015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24516262" @default.
- W2095622015 hasPublicationYear "2014" @default.
- W2095622015 type Work @default.
- W2095622015 sameAs 2095622015 @default.
- W2095622015 citedByCount "20" @default.
- W2095622015 countsByYear W20956220152014 @default.
- W2095622015 countsByYear W20956220152015 @default.
- W2095622015 countsByYear W20956220152016 @default.
- W2095622015 countsByYear W20956220152017 @default.
- W2095622015 countsByYear W20956220152019 @default.
- W2095622015 countsByYear W20956220152020 @default.
- W2095622015 countsByYear W20956220152021 @default.
- W2095622015 countsByYear W20956220152022 @default.
- W2095622015 crossrefType "journal-article" @default.
- W2095622015 hasAuthorship W2095622015A5018214967 @default.
- W2095622015 hasAuthorship W2095622015A5020653419 @default.
- W2095622015 hasAuthorship W2095622015A5020882457 @default.
- W2095622015 hasAuthorship W2095622015A5055978192 @default.
- W2095622015 hasAuthorship W2095622015A5062465642 @default.
- W2095622015 hasAuthorship W2095622015A5074715876 @default.
- W2095622015 hasAuthorship W2095622015A5082442667 @default.
- W2095622015 hasBestOaLocation W20956220151 @default.
- W2095622015 hasConcept C1008401 @default.
- W2095622015 hasConcept C104317684 @default.
- W2095622015 hasConcept C118303440 @default.
- W2095622015 hasConcept C126322002 @default.
- W2095622015 hasConcept C134018914 @default.
- W2095622015 hasConcept C137620995 @default.
- W2095622015 hasConcept C163170386 @default.
- W2095622015 hasConcept C170033053 @default.
- W2095622015 hasConcept C170493617 @default.
- W2095622015 hasConcept C185592680 @default.
- W2095622015 hasConcept C202751555 @default.
- W2095622015 hasConcept C2776033226 @default.
- W2095622015 hasConcept C2776541429 @default.
- W2095622015 hasConcept C2776886416 @default.
- W2095622015 hasConcept C2777267240 @default.