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• W2095627243 abstract "Introduction ACE-031 is a soluble form of activin receptor type IIB (ActRIIB). ACE-031 promotes muscle growth by binding to myostatin and other negative regulators of muscle mass. Methods This double-blind, placebo-controlled study evaluated the safety, pharmacokinetics, and pharmacodynamics of ACE-031 in 48 healthy, postmenopausal women randomized to receive 1 dose of ACE-031 (0.02–3 mg/kg SC) or placebo (3:1). Results ACE-031 was generally well-tolerated. Adverse events included injection site erythema. Mean ACE-031 AUC0–∞ and Cmax increased linearly with dose; mean T½ was 10–15 days. Statistically significant increases in mean total body lean mass (3.3%; P = 0.03, by DXA) and thigh muscle volume (5.1%; P = 0.03, by MRI) were observed at day 29 in the 3 mg/kg group. Statistically significant changes in serum biomarkers suggest ACE-031 also improved bone and fat metabolism. Conclusions Single-dose ACE-031 treatment was generally well-tolerated and resulted in increases in muscle mass in healthy postmenopausal women. Muscle Nerve [B]47[/B]: 416–423, 2013" @default.
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• W2095627243 date "2012-11-21" @default.
• W2095627243 modified "2023-10-05" @default.
• W2095627243 title "A single ascending-dose study of muscle regulator ace-031 in healthy volunteers" @default.
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• W2095627243 doi "https://doi.org/10.1002/mus.23539" @default.
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