FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095627868> ?p ?o ?g. }

• W2095627868 endingPage "518" @default.
• W2095627868 startingPage "509" @default.
• W2095627868 abstract "We examined the effects of chronic centrally administered leptin on the glucose metabolism of streptozotocin-induced diabetic (STZ-D) rats, a model for insulin-dependent diabetes mellitus. When 3 microg.rat(-1).day(-1) of leptin was infused into the third ventricle for 6 consecutive days (STZ-LEP), STZ-D rats became completely euglycemic. The effect was not seen when the same dosage was administered s.c. Centrally administered leptin did not affect peripheral insulin levels. The feeding volume of STZ-LEP rats was suppressed to the level of non-STZ-D control rats. No improvement of hyperglycemia was noted when STZ-D rats were pair-fed to match the feeding volume of STZ-LEP rats. Thus, the euglycemia of STZ-LEP rats cannot be due to the decreased feeding volume. In the STZ-D rat, glucokinase mRNA, a marker of glycolysis, is down-regulated whereas glucose-6-phosphatase mRNA, a marker of gluconeogenesis, and glucose transporter (GLUT) 2, which is implicated in the release of glucose from liver, are up-regulated. GLUT4, uncoupling protein (UCP) 1, and UCP3 were down-regulated in brown adipose tissue. These parameters returned to normal upon central infusion of leptin. GLUT4 was not down-regulated in the skeletal muscle of STZ-D rats; however, fatty acid binding protein and carnitine palmitoyltransferase I, markers for utilization and beta-oxidation of fatty acids, were up-regulated and restored when the rats were treated with leptin. The increase and subsequent decrease of fatty acid utilization suggests a decrease of glucose uptake in the skeletal muscle of STZ-D rats, which was restored upon central leptin administration. We conclude that centrally infused leptin does not control serum glucose by regulating feeding volume or elevating peripheral insulin, but by regulating hepatic glucose production, peripheral glucose uptake, and energy expenditure. The present study indicates the possibility of future development of a new class of anti-diabetic agents that act centrally and independent of insulin action." @default.
• W2095627868 created "2016-06-24" @default.
• W2095627868 creator A5014297176 @default.
• W2095627868 creator A5024685157 @default.
• W2095627868 creator A5024831118 @default.
• W2095627868 creator A5030700797 @default.
• W2095627868 creator A5035912450 @default.
• W2095627868 creator A5056328628 @default.
• W2095627868 creator A5066906740 @default.
• W2095627868 creator A5070094451 @default.
• W2095627868 creator A5070474200 @default.
• W2095627868 creator A5081807936 @default.
• W2095627868 creator A5083726183 @default.
• W2095627868 date "2002-04-01" @default.
• W2095627868 modified "2023-10-17" @default.
• W2095627868 title "Chronic central leptin infusion restores hyperglycemia independent of food intake and insulin level in streptozotocin‐induced diabetic rats" @default.
• W2095627868 cites W1492605893 @default.
• W2095627868 cites W1493726376 @default.
• W2095627868 cites W1501851749 @default.
• W2095627868 cites W1509104855 @default.
• W2095627868 cites W1550000221 @default.
• W2095627868 cites W1580569338 @default.
• W2095627868 cites W1587563569 @default.
• W2095627868 cites W1631449371 @default.
• W2095627868 cites W166370444 @default.
• W2095627868 cites W1749436095 @default.
• W2095627868 cites W1870380602 @default.
• W2095627868 cites W1915944311 @default.
• W2095627868 cites W1944789111 @default.
• W2095627868 cites W1967206579 @default.
• W2095627868 cites W1972970479 @default.
• W2095627868 cites W1987355039 @default.
• W2095627868 cites W1989909218 @default.
• W2095627868 cites W2001716823 @default.
• W2095627868 cites W2021295629 @default.
• W2095627868 cites W2027360957 @default.
• W2095627868 cites W2057140766 @default.
• W2095627868 cites W2060682066 @default.
• W2095627868 cites W2061340727 @default.
• W2095627868 cites W2067324334 @default.
• W2095627868 cites W2076823992 @default.
• W2095627868 cites W2076944010 @default.
• W2095627868 cites W2077961548 @default.
• W2095627868 cites W2079185127 @default.
• W2095627868 cites W2085529816 @default.
• W2095627868 cites W2096299662 @default.
• W2095627868 cites W2100399061 @default.
• W2095627868 cites W2103893515 @default.
• W2095627868 cites W2112457773 @default.
• W2095627868 cites W2113808580 @default.
• W2095627868 cites W2123013611 @default.
• W2095627868 cites W2137993789 @default.
• W2095627868 cites W2140366479 @default.
• W2095627868 cites W2147062559 @default.
• W2095627868 cites W2148844770 @default.
• W2095627868 cites W2152760501 @default.
• W2095627868 cites W2327640792 @default.
• W2095627868 cites W4238938284 @default.
• W2095627868 cites W4245866536 @default.
• W2095627868 doi "https://doi.org/10.1096/fj.01-0164com" @default.
• W2095627868 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11919153" @default.
• W2095627868 hasPublicationYear "2002" @default.
• W2095627868 type Work @default.
• W2095627868 sameAs 2095627868 @default.
• W2095627868 citedByCount "100" @default.
• W2095627868 countsByYear W20956278682012 @default.
• W2095627868 countsByYear W20956278682013 @default.
• W2095627868 countsByYear W20956278682014 @default.
• W2095627868 countsByYear W20956278682015 @default.
• W2095627868 countsByYear W20956278682016 @default.
• W2095627868 countsByYear W20956278682017 @default.
• W2095627868 countsByYear W20956278682018 @default.
• W2095627868 countsByYear W20956278682020 @default.
• W2095627868 countsByYear W20956278682021 @default.
• W2095627868 countsByYear W20956278682022 @default.
• W2095627868 countsByYear W20956278682023 @default.
• W2095627868 crossrefType "journal-article" @default.
• W2095627868 hasAuthorship W2095627868A5014297176 @default.
• W2095627868 hasAuthorship W2095627868A5024685157 @default.
• W2095627868 hasAuthorship W2095627868A5024831118 @default.
• W2095627868 hasAuthorship W2095627868A5030700797 @default.
• W2095627868 hasAuthorship W2095627868A5035912450 @default.
• W2095627868 hasAuthorship W2095627868A5056328628 @default.
• W2095627868 hasAuthorship W2095627868A5066906740 @default.
• W2095627868 hasAuthorship W2095627868A5070094451 @default.
• W2095627868 hasAuthorship W2095627868A5070474200 @default.
• W2095627868 hasAuthorship W2095627868A5081807936 @default.
• W2095627868 hasAuthorship W2095627868A5083726183 @default.
• W2095627868 hasConcept C126322002 @default.
• W2095627868 hasConcept C134018914 @default.
• W2095627868 hasConcept C161573976 @default.
• W2095627868 hasConcept C185592680 @default.
• W2095627868 hasConcept C2776188179 @default.
• W2095627868 hasConcept C2777866211 @default.
• W2095627868 hasConcept C2779280383 @default.
• W2095627868 hasConcept C2779306644 @default.
• W2095627868 hasConcept C2780613262 @default.
• W2095627868 hasConcept C511355011 @default.

• next