Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095647488> ?p ?o ?g. }
- W2095647488 endingPage "4146" @default.
- W2095647488 startingPage "4146" @default.
- W2095647488 abstract "HBTM-2.1 promotes the catalytic asymmetric intermolecular Michael-lactonisation of arylacetic acids and trifluoromethylenones in the presence of pivaloyl chloride, giving C(6)-trifluoromethyldihydropyranones with high diastereo- and enantiocontrol (up to 95 : 5 dr and >99% ee) that are readily derivatised to diverse synthetic building blocks containing trifluoromethyl-stereogenicity. Kinetic studies indicate the reaction is first order with respect to both in situ formed mixed anhydride and catalyst concentration, with a primary kinetic isotope effect observed using α,α-di-deuterio 4-fluorophenylacetic acid, consistent with rate determining deprotonation of an intermediate acyl isothiouronium ion." @default.
- W2095647488 created "2016-06-24" @default.
- W2095647488 creator A5001147371 @default.
- W2095647488 creator A5002099116 @default.
- W2095647488 creator A5008076070 @default.
- W2095647488 creator A5017519455 @default.
- W2095647488 creator A5049970193 @default.
- W2095647488 creator A5050603703 @default.
- W2095647488 date "2013-01-01" @default.
- W2095647488 modified "2023-10-18" @default.
- W2095647488 title "Isothiourea-mediated asymmetric Michael-lactonisation of trifluoromethylenones: a synthetic and mechanistic study" @default.
- W2095647488 cites W142358202 @default.
- W2095647488 cites W1964430453 @default.
- W2095647488 cites W1971170377 @default.
- W2095647488 cites W1971843402 @default.
- W2095647488 cites W1974055981 @default.
- W2095647488 cites W1974405440 @default.
- W2095647488 cites W1974833464 @default.
- W2095647488 cites W1975833150 @default.
- W2095647488 cites W1977024991 @default.
- W2095647488 cites W1983401069 @default.
- W2095647488 cites W1987481720 @default.
- W2095647488 cites W1988622258 @default.
- W2095647488 cites W1991110564 @default.
- W2095647488 cites W1991603945 @default.
- W2095647488 cites W1993004216 @default.
- W2095647488 cites W1994099424 @default.
- W2095647488 cites W1997367863 @default.
- W2095647488 cites W1997508293 @default.
- W2095647488 cites W1998048848 @default.
- W2095647488 cites W1998485983 @default.
- W2095647488 cites W2000610892 @default.
- W2095647488 cites W2000813299 @default.
- W2095647488 cites W2002706652 @default.
- W2095647488 cites W2003907109 @default.
- W2095647488 cites W2006251908 @default.
- W2095647488 cites W2007414373 @default.
- W2095647488 cites W2010442230 @default.
- W2095647488 cites W2011792078 @default.
- W2095647488 cites W2014721806 @default.
- W2095647488 cites W2016731880 @default.
- W2095647488 cites W2018584158 @default.
- W2095647488 cites W2020155243 @default.
- W2095647488 cites W2020686421 @default.
- W2095647488 cites W2022969300 @default.
- W2095647488 cites W2024600015 @default.
- W2095647488 cites W2025085392 @default.
- W2095647488 cites W2026857935 @default.
- W2095647488 cites W2031390489 @default.
- W2095647488 cites W2032326469 @default.
- W2095647488 cites W2033043158 @default.
- W2095647488 cites W2033451838 @default.
- W2095647488 cites W2035382144 @default.
- W2095647488 cites W2036983066 @default.
- W2095647488 cites W2040042858 @default.
- W2095647488 cites W2041219357 @default.
- W2095647488 cites W2041375052 @default.
- W2095647488 cites W2041578682 @default.
- W2095647488 cites W2042415587 @default.
- W2095647488 cites W2047603800 @default.
- W2095647488 cites W2047722578 @default.
- W2095647488 cites W2050404939 @default.
- W2095647488 cites W2050547179 @default.
- W2095647488 cites W2052512352 @default.
- W2095647488 cites W2056759062 @default.
- W2095647488 cites W2057603342 @default.
- W2095647488 cites W2057706874 @default.
- W2095647488 cites W2060231012 @default.
- W2095647488 cites W2060809644 @default.
- W2095647488 cites W2061118541 @default.
- W2095647488 cites W2064249788 @default.
- W2095647488 cites W2064385187 @default.
- W2095647488 cites W2066850974 @default.
- W2095647488 cites W2071648083 @default.
- W2095647488 cites W2072498345 @default.
- W2095647488 cites W2075180842 @default.
- W2095647488 cites W2086885624 @default.
- W2095647488 cites W2087119102 @default.
- W2095647488 cites W2088977116 @default.
- W2095647488 cites W2089381297 @default.
- W2095647488 cites W2090539813 @default.
- W2095647488 cites W2091786294 @default.
- W2095647488 cites W2091924566 @default.
- W2095647488 cites W2098879971 @default.
- W2095647488 cites W2103623852 @default.
- W2095647488 cites W2103667004 @default.
- W2095647488 cites W2103867318 @default.
- W2095647488 cites W2110907939 @default.
- W2095647488 cites W2116087305 @default.
- W2095647488 cites W2119240496 @default.
- W2095647488 cites W2121149540 @default.
- W2095647488 cites W2122853612 @default.
- W2095647488 cites W2123331806 @default.
- W2095647488 cites W2124164986 @default.
- W2095647488 cites W2124558767 @default.
- W2095647488 cites W2124590109 @default.
- W2095647488 cites W2125099147 @default.
- W2095647488 cites W2126701196 @default.