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- W2095670074 abstract "Exposure to high levels of genotoxic stress, such as high-dose ionizing radiation, increases both cancer and noncancer risks. However, it remains debatable whether low-dose ionizing radiation reduces cellular function, or rather induces hormetic health benefits. Here, we investigated the effects of total-body γ-ray radiation on muscle stem cells, called satellite cells. Adult C57BL/6 mice were exposed to γ-radiation at low- to high-dose rates (low, 2 or 10 mGy/day; moderate, 50 mGy/day; high, 250 mGy/day) for 30 days. No hormetic responses in proliferation, differentiation, or self-renewal of satellite cells were observed in low-dose radiation-exposed mice at the acute phase. However, at the chronic phase, population expansion of satellite cell-derived progeny was slightly decreased in mice exposed to low-dose radiation. Taken together, low-dose ionizing irradiation may suppress satellite cell function, rather than induce hormetic health benefits, in skeletal muscle in adult mice." @default.
- W2095670074 created "2016-06-24" @default.
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- W2095670074 date "2015-04-01" @default.
- W2095670074 modified "2023-09-30" @default.
- W2095670074 title "Time- and dose-dependent effects of total-body ionizing radiation on muscle stem cells" @default.
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- W2095670074 doi "https://doi.org/10.14814/phy2.12377" @default.
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