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- W2095678840 endingPage "107" @default.
- W2095678840 startingPage "89" @default.
- W2095678840 abstract "Chronic obstructive pulmonary disease (COPD) defines a group of chronic inflammatory disorders of the airways that are characterised by a progressive and largely irreversible decline in expiratory airflow. Drugs used to treat COPD through actions mediated by cyclic AMP (cAMP) are restricted to long-acting and short-acting β2-adrenoceptor agonists and, in a subset of patients with chronic bronchitis, a phosphodiesterase 4 inhibitor, roflumilast. These agents relax airway smooth muscle and suppress inflammation. At the molecular level, these effects in the airways are mediated by two cAMP effectors, cAMP-dependent protein kinase and exchange proteins activated by cAMP. The pharmacology of newer agents, acting through these systems, is discussed here with an emphasis on their potential to interact and increase therapeutic effectiveness." @default.
- W2095678840 created "2016-06-24" @default.
- W2095678840 creator A5018753336 @default.
- W2095678840 creator A5044655061 @default.
- W2095678840 date "2014-06-01" @default.
- W2095678840 modified "2023-09-25" @default.
- W2095678840 title "Cyclic nucleotide-based therapeutics for chronic obstructive pulmonary disease" @default.
- W2095678840 cites W10841170 @default.
- W2095678840 cites W1495367679 @default.
- W2095678840 cites W1495764983 @default.
- W2095678840 cites W1511208409 @default.
- W2095678840 cites W1516098178 @default.
- W2095678840 cites W1522773084 @default.
- W2095678840 cites W1524361670 @default.
- W2095678840 cites W1526605585 @default.
- W2095678840 cites W1532553896 @default.
- W2095678840 cites W1592483428 @default.
- W2095678840 cites W1717444875 @default.
- W2095678840 cites W1877755747 @default.
- W2095678840 cites W1920721512 @default.
- W2095678840 cites W1964897436 @default.
- W2095678840 cites W1965759778 @default.
- W2095678840 cites W1968919978 @default.
- W2095678840 cites W1972029787 @default.
- W2095678840 cites W1973664081 @default.
- W2095678840 cites W1976861853 @default.
- W2095678840 cites W1977040622 @default.
- W2095678840 cites W1981555245 @default.
- W2095678840 cites W1981784186 @default.
- W2095678840 cites W1984298671 @default.
- W2095678840 cites W1985171602 @default.
- W2095678840 cites W1986340882 @default.
- W2095678840 cites W1992243758 @default.
- W2095678840 cites W1994226794 @default.
- W2095678840 cites W1996313966 @default.
- W2095678840 cites W1996862621 @default.
- W2095678840 cites W1997210895 @default.
- W2095678840 cites W1997277329 @default.
- W2095678840 cites W1997530829 @default.
- W2095678840 cites W1998079127 @default.
- W2095678840 cites W1998717373 @default.
- W2095678840 cites W2000309387 @default.
- W2095678840 cites W2000424051 @default.
- W2095678840 cites W200048665 @default.
- W2095678840 cites W2001060669 @default.
- W2095678840 cites W2001084487 @default.
- W2095678840 cites W2011991411 @default.
- W2095678840 cites W2013672040 @default.
- W2095678840 cites W2014705718 @default.
- W2095678840 cites W2016018338 @default.
- W2095678840 cites W2020381729 @default.
- W2095678840 cites W2021655390 @default.
- W2095678840 cites W2021965311 @default.
- W2095678840 cites W2024940940 @default.
- W2095678840 cites W2025159951 @default.
- W2095678840 cites W2027580901 @default.
- W2095678840 cites W2028637591 @default.
- W2095678840 cites W2028733293 @default.
- W2095678840 cites W2029299795 @default.
- W2095678840 cites W2029429802 @default.
- W2095678840 cites W2030536223 @default.
- W2095678840 cites W2031096165 @default.
- W2095678840 cites W2031230900 @default.
- W2095678840 cites W2035090144 @default.
- W2095678840 cites W2035592877 @default.
- W2095678840 cites W2036717451 @default.
- W2095678840 cites W2037738804 @default.
- W2095678840 cites W2038046576 @default.
- W2095678840 cites W2038514482 @default.
- W2095678840 cites W2042025041 @default.
- W2095678840 cites W2044045740 @default.
- W2095678840 cites W2044670482 @default.
- W2095678840 cites W2045616259 @default.
- W2095678840 cites W2045739339 @default.
- W2095678840 cites W2049610222 @default.
- W2095678840 cites W2050611911 @default.
- W2095678840 cites W2050700715 @default.
- W2095678840 cites W2050774740 @default.
- W2095678840 cites W2053798956 @default.
- W2095678840 cites W2054274831 @default.
- W2095678840 cites W2055968736 @default.
- W2095678840 cites W2057077772 @default.
- W2095678840 cites W2057335633 @default.
- W2095678840 cites W2059435466 @default.
- W2095678840 cites W2059828011 @default.
- W2095678840 cites W2060503785 @default.
- W2095678840 cites W2062075871 @default.
- W2095678840 cites W2065087108 @default.
- W2095678840 cites W2065796973 @default.
- W2095678840 cites W2066802401 @default.
- W2095678840 cites W2072494863 @default.
- W2095678840 cites W2075076595 @default.
- W2095678840 cites W2077201251 @default.
- W2095678840 cites W2077988199 @default.
- W2095678840 cites W2078892718 @default.
- W2095678840 cites W2080166395 @default.
- W2095678840 cites W2085411745 @default.
- W2095678840 cites W2085432102 @default.