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• W2095682761 abstract "Every year, meningococcal meningitis causes thousands of deaths within the meningitis belt in sub-Saharan African countries. Large epidemic waves occur with a periodicity of 5–12 years. The waves do correspond to molecular changes in the expression of capsular or subcapsular antigens, which allow the bug to spread in susceptible populations. Serogroup A remains the major killer, even if in 2002, serogroup W135 ST-11 emerged in Burkina Faso, causing an important epidemic. However, the surveillance in the following years has showed a decrease in the W135 incidence and a clear predominance of serogroup A. Moreover, a new serogroup A strain belonging to ST-2859 seems to emerge and does represent a new threat for the coming seasons. In a vaccine perspective, and especially in the context of the development of an A conjugate vaccine; it is the key to strengthen the surveillance systems and to include molecular epidemiology as a tool for monitoring the molecular evolution of Neisseria meningitidis in Africa." @default.
• W2095682761 created "2016-06-24" @default.
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• W2095682761 date "2007-09-01" @default.
• W2095682761 modified "2023-09-26" @default.
• W2095682761 title "Meningitis epidemics in Africa: A brief overview" @default.
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• W2095682761 doi "https://doi.org/10.1016/j.vaccine.2007.04.032" @default.
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