Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095682923> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2095682923 endingPage "179" @default.
- W2095682923 startingPage "167" @default.
- W2095682923 abstract "The purpose of this study was to investigate the influence of micronization technique on performance and stability of the model drug formulated in a suspension-based pressurized metered-dose inhaler (pMDI). The model drug, triamcinolone acetonide (TAA), was subjected to ball milling or air-jet milling prior to formulation of the pMDI. The dose delivery characteristics of the emitted aerosol cloud were monitored for the ball-milled, air-jet-milled, and unmicronized TAA pMDI formulations prior to and after storage at 25 and 40 degrees C. Cascade impaction was used to determine the aerodynamic particle size distribution of the emitted dose. Both micronization techniques reduced the drug particle size distribution and the polydispersity of the drug particles to a similar extent, but the ball-milling technique reduced the crystallinity of the drug to a greater degree compared to the air-jet-milling technique. The air-jet-milled and unmicronized TAA pMDI displayed similar aerodynamic particle size distributions of the emitted aerosol and respirable fractions over the storage period. The ball-milled TAA resulted in a pMDI formulation with the smallest aerodynamically sized particles and the highest respirable fraction compared to the air-jet-milled or unmicronized TAA pMDI formulations. The micronization techniques significantly influenced the dose delivery characteristics as a result of different initial particle size distributions, amorphous contents, and surface energies." @default.
- W2095682923 created "2016-06-24" @default.
- W2095682923 creator A5055542138 @default.
- W2095682923 creator A5085352453 @default.
- W2095682923 creator A5086084872 @default.
- W2095682923 date "1999-01-01" @default.
- W2095682923 modified "2023-10-16" @default.
- W2095682923 title "Influence of Micronization Method on the Performance of a Suspension Triamcinolone Acetonide Pressurized Metered-Dose Inhaler Formulation" @default.
- W2095682923 cites W104245145 @default.
- W2095682923 cites W1505046058 @default.
- W2095682923 cites W1569044311 @default.
- W2095682923 cites W1971504327 @default.
- W2095682923 cites W1986769022 @default.
- W2095682923 cites W2013517861 @default.
- W2095682923 cites W2021996583 @default.
- W2095682923 cites W2033789057 @default.
- W2095682923 cites W2043797786 @default.
- W2095682923 cites W2055530178 @default.
- W2095682923 cites W2078769097 @default.
- W2095682923 cites W2094879476 @default.
- W2095682923 cites W25654423 @default.
- W2095682923 cites W298643844 @default.
- W2095682923 cites W56491376 @default.
- W2095682923 doi "https://doi.org/10.1081/pdt-100101351" @default.
- W2095682923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10231878" @default.
- W2095682923 hasPublicationYear "1999" @default.
- W2095682923 type Work @default.
- W2095682923 sameAs 2095682923 @default.
- W2095682923 citedByCount "39" @default.
- W2095682923 countsByYear W20956829232012 @default.
- W2095682923 countsByYear W20956829232013 @default.
- W2095682923 countsByYear W20956829232014 @default.
- W2095682923 countsByYear W20956829232015 @default.
- W2095682923 countsByYear W20956829232016 @default.
- W2095682923 countsByYear W20956829232018 @default.
- W2095682923 crossrefType "journal-article" @default.
- W2095682923 hasAuthorship W2095682923A5055542138 @default.
- W2095682923 hasAuthorship W2095682923A5085352453 @default.
- W2095682923 hasAuthorship W2095682923A5086084872 @default.
- W2095682923 hasConcept C11432220 @default.
- W2095682923 hasConcept C126322002 @default.
- W2095682923 hasConcept C127413603 @default.
- W2095682923 hasConcept C159985019 @default.
- W2095682923 hasConcept C178790620 @default.
- W2095682923 hasConcept C185592680 @default.
- W2095682923 hasConcept C187530423 @default.
- W2095682923 hasConcept C188027245 @default.
- W2095682923 hasConcept C192562407 @default.
- W2095682923 hasConcept C2776042228 @default.
- W2095682923 hasConcept C2779345167 @default.
- W2095682923 hasConcept C2780261241 @default.
- W2095682923 hasConcept C2780667556 @default.
- W2095682923 hasConcept C42360764 @default.
- W2095682923 hasConcept C43617362 @default.
- W2095682923 hasConcept C60448018 @default.
- W2095682923 hasConcept C71924100 @default.
- W2095682923 hasConcept C86178769 @default.
- W2095682923 hasConceptScore W2095682923C11432220 @default.
- W2095682923 hasConceptScore W2095682923C126322002 @default.
- W2095682923 hasConceptScore W2095682923C127413603 @default.
- W2095682923 hasConceptScore W2095682923C159985019 @default.
- W2095682923 hasConceptScore W2095682923C178790620 @default.
- W2095682923 hasConceptScore W2095682923C185592680 @default.
- W2095682923 hasConceptScore W2095682923C187530423 @default.
- W2095682923 hasConceptScore W2095682923C188027245 @default.
- W2095682923 hasConceptScore W2095682923C192562407 @default.
- W2095682923 hasConceptScore W2095682923C2776042228 @default.
- W2095682923 hasConceptScore W2095682923C2779345167 @default.
- W2095682923 hasConceptScore W2095682923C2780261241 @default.
- W2095682923 hasConceptScore W2095682923C2780667556 @default.
- W2095682923 hasConceptScore W2095682923C42360764 @default.
- W2095682923 hasConceptScore W2095682923C43617362 @default.
- W2095682923 hasConceptScore W2095682923C60448018 @default.
- W2095682923 hasConceptScore W2095682923C71924100 @default.
- W2095682923 hasConceptScore W2095682923C86178769 @default.
- W2095682923 hasIssue "2" @default.
- W2095682923 hasLocation W20956829231 @default.
- W2095682923 hasLocation W20956829232 @default.
- W2095682923 hasOpenAccess W2095682923 @default.
- W2095682923 hasPrimaryLocation W20956829231 @default.
- W2095682923 hasRelatedWork W1993914395 @default.
- W2095682923 hasRelatedWork W1998827928 @default.
- W2095682923 hasRelatedWork W2004478095 @default.
- W2095682923 hasRelatedWork W2036941339 @default.
- W2095682923 hasRelatedWork W2066769504 @default.
- W2095682923 hasRelatedWork W2090699601 @default.
- W2095682923 hasRelatedWork W2095682923 @default.
- W2095682923 hasRelatedWork W2162566700 @default.
- W2095682923 hasRelatedWork W2780404330 @default.
- W2095682923 hasRelatedWork W3046794503 @default.
- W2095682923 hasVolume "4" @default.
- W2095682923 isParatext "false" @default.
- W2095682923 isRetracted "false" @default.
- W2095682923 magId "2095682923" @default.
- W2095682923 workType "article" @default.