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- W2095683716 abstract "ABSTRACT The homeobox gene Nkx2-5 is the earliest known marker of the cardiac lineage in vertebrate embryos. Nkx2-5 expression is first detected in mesodermal cells specified to form heart at embryonic day 7.5 in the mouse and expression is maintained throughout the developing and adult heart. In addition to the heart, Nkx2-5 is transiently expressed in the developing pharynx, thyroid and stomach. To investigate the mechanisms that initiate cardiac transcription during embryogenesis, we analyzed the Nkx2-5 upstream region for regulatory elements sufficient to direct expression of a lacZ transgene in the developing heart of transgenic mice. We describe a cardiac enhancer, located about 9 kilobases upstream of the Nkx2-5 gene, that fully recapitulates the expression pattern of the endogenous gene in cardiogenic precursor cells from the onset of cardiac lineage specification and throughout the linear and looping heart tube. Thereafter, as the atrial and ventricular chambers become demarcated, enhancer activity becomes restricted to the developing right ventricle. Transcription of Nkx2-5 in pharynx, thyroid and stomach is controlled by regulatory elements separable from the cardiac enhancer. This distal cardiac enhancer contains a high-affinity binding site for the cardiac-restricted zinc finger transcription factor GATA4 that is essential for transcriptional activity. These results reveal a novel GATA-dependent mechanism for activation of Nkx2-5 transcription in the developing heart and indicate that regulation of Nkx2-5 is controlled in a modular manner, with multiple regulatory regions responding to distinct transcriptional networks in different compartments of the developing heart." @default.
- W2095683716 created "2016-06-24" @default.
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- W2095683716 date "1999-01-01" @default.
- W2095683716 modified "2023-10-12" @default.
- W2095683716 title "Control of early cardiac-specific transcription of <i>Nkx2-5</i> by a GATA-dependent enhancer" @default.
- W2095683716 cites W1489316903 @default.
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- W2095683716 cites W1900422662 @default.
- W2095683716 cites W1934786235 @default.
- W2095683716 cites W1956857062 @default.
- W2095683716 cites W1971977081 @default.
- W2095683716 cites W1972613882 @default.
- W2095683716 cites W1973738440 @default.
- W2095683716 cites W1974703394 @default.
- W2095683716 cites W1976551887 @default.
- W2095683716 cites W1977746306 @default.
- W2095683716 cites W1979103216 @default.
- W2095683716 cites W1990158689 @default.
- W2095683716 cites W1991703781 @default.
- W2095683716 cites W1993250186 @default.
- W2095683716 cites W1993862102 @default.
- W2095683716 cites W1994193635 @default.
- W2095683716 cites W1995640088 @default.
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- W2095683716 cites W1998340594 @default.
- W2095683716 cites W2000290760 @default.
- W2095683716 cites W2004537703 @default.
- W2095683716 cites W2010332455 @default.
- W2095683716 cites W2015840464 @default.
- W2095683716 cites W2022598338 @default.
- W2095683716 cites W2028352714 @default.
- W2095683716 cites W2037241011 @default.
- W2095683716 cites W2049073959 @default.
- W2095683716 cites W2050173039 @default.
- W2095683716 cites W2058893102 @default.
- W2095683716 cites W2063679739 @default.
- W2095683716 cites W2064586774 @default.
- W2095683716 cites W2066092773 @default.
- W2095683716 cites W2066398820 @default.
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- W2095683716 cites W2078587203 @default.
- W2095683716 cites W2086067630 @default.
- W2095683716 cites W2091441330 @default.
- W2095683716 cites W2098983125 @default.
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- W2095683716 cites W2125655548 @default.
- W2095683716 cites W2126393744 @default.
- W2095683716 cites W2129082959 @default.
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- W2095683716 cites W2135801344 @default.
- W2095683716 cites W2136888267 @default.
- W2095683716 cites W2138283132 @default.
- W2095683716 cites W2140828381 @default.
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- W2095683716 cites W2184560410 @default.
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- W2095683716 doi "https://doi.org/10.1242/dev.126.1.75" @default.
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