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- W2095683770 abstract "Primary focal and segmental glomerulosclerosis (FSGS) may be due to genetic or acquired etiologies and is a common cause of nephrotic syndrome with high morbidity that often leads to end-stage renal failure. The different available therapeutic approaches are unsuccessful, in part due to partially deciphered heterogeneous and complex pathophysiological mechanisms. Moreover, the term FSGS, even in its primary form, comprises a histological description shared by a number of different causes with completely different molecular pathways of disease. This review focuses on the latest developments regarding the pathophysiology of primary acquired FSGS caused by soluble factor urokinase type plasminogen activator receptor, a circulating permeability factor involved in proteinuria and edema formation, and describes recent advances with potential success in therapy." @default.
- W2095683770 created "2016-06-24" @default.
- W2095683770 creator A5075435520 @default.
- W2095683770 date "2013-11-06" @default.
- W2095683770 modified "2023-10-17" @default.
- W2095683770 title "Primary focal and segmental glomerulosclerosis and soluble factor urokinase-type plasminogen activator receptor." @default.
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- W2095683770 doi "https://doi.org/10.5527/wjn.v2.i4.103" @default.
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