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• W2095686531 abstract "Dementia with Lewy bodies (DLB) is the second most common type of degenerative dementia following Alzheimer’s disease (AD). DLB is clinically and pathologically related to Parkinson's disease (PD) and PD dementia, and the three disorders can be viewed as existing on a spectrum of Lewy body disease. In recent years there has been a concerted effort to establish the phenotypes of AD and PD in the prodromal phase (before the respective syndromes of cognitive and motor impairment are expressed). Evidence for the prodromal presentation of DLB is also emerging. This paper briefly reviews what is known about the clinical presentation of prodromal DLB before discussing the pathology of Lewy body disease and how this relates to potential biomarkers of prodromal DLB. The presenting features of DLB can be broadly placed in three categories: cognitive impairment (particularly nonamnestic cognitive impairments), behavioural/psychiatric phenomena (for example, hallucinations, rapid eye movement sleep behaviour disorder (RBD)) and physical symptoms (for example, parkinsonism, decreased sense of smell, autonomic dysfunction). Some noncognitive symptoms such as constipation, RBD, hyposmia and postural dizziness can predate the onset of memory impairment by several years in DLB. Pathological studies of Lewy body disease have found that the earliest sites of involvement are the olfactory bulb, the dorsal motor nucleus of the vagal nerve, the peripheral autonomic nervous system, including the enteric nervous system, and the brainstem. Some of the most promising early markers for DLB include the presence of RBD, autonomic dysfunction or hyposmia, 123I-metaiodobenzylguanidine cardiac scintigraphy, measures of substantia nigra pathology and skin biopsy for α-synuclein in peripheral autonomic nerves. In the absence of disease-modifying therapies, the diagnosis of prodromal DLB is of limited use in the clinic. That said, knowledge of the prodromal development of DLB could help clinicians identify cases of DLB where the diagnosis is uncertain. Prodromal diagnosis is of great importance in research, where identifying Lewy body disease at an earlier stage may allow researchers to investigate the initial phases of dementia pathophysiology, develop treatments designed to interrupt the development of the dementia syndrome and accurately identify the patients most likely to benefit from these treatments." @default.
• W2095686531 created "2016-06-24" @default.
• W2095686531 creator A5003002074 @default.
• W2095686531 creator A5082040813 @default.
• W2095686531 date "2014-01-01" @default.
• W2095686531 modified "2023-09-30" @default.
• W2095686531 title "The clinical characteristics of dementia with Lewy bodies and a consideration of prodromal diagnosis" @default.
• W2095686531 cites W1519095619 @default.
• W2095686531 cites W1576863455 @default.
• W2095686531 cites W1623872991 @default.
• W2095686531 cites W1762460815 @default.
• W2095686531 cites W1906129472 @default.
• W2095686531 cites W1964132756 @default.
• W2095686531 cites W1968324269 @default.
• W2095686531 cites W1969541118 @default.
• W2095686531 cites W1971001612 @default.
• W2095686531 cites W1972528312 @default.
• W2095686531 cites W1972567980 @default.
• W2095686531 cites W1972982304 @default.
• W2095686531 cites W1979444935 @default.
• W2095686531 cites W1987744512 @default.
• W2095686531 cites W1990925574 @default.
• W2095686531 cites W1991244321 @default.
• W2095686531 cites W1992257573 @default.
• W2095686531 cites W1993986576 @default.
• W2095686531 cites W2002969658 @default.
• W2095686531 cites W2006247983 @default.
• W2095686531 cites W2007705801 @default.
• W2095686531 cites W2014073709 @default.
• W2095686531 cites W2016620094 @default.
• W2095686531 cites W2018993369 @default.
• W2095686531 cites W2019145949 @default.
• W2095686531 cites W2022378738 @default.
• W2095686531 cites W2022850153 @default.
• W2095686531 cites W2023770909 @default.
• W2095686531 cites W2024244685 @default.
• W2095686531 cites W2033343502 @default.
• W2095686531 cites W2033827101 @default.
• W2095686531 cites W2036280154 @default.
• W2095686531 cites W2044663741 @default.
• W2095686531 cites W2045138012 @default.
• W2095686531 cites W2046533388 @default.
• W2095686531 cites W2050113652 @default.
• W2095686531 cites W2052226124 @default.
• W2095686531 cites W2056304503 @default.
• W2095686531 cites W2058914023 @default.
• W2095686531 cites W2059431752 @default.
• W2095686531 cites W2064284597 @default.
• W2095686531 cites W2066674357 @default.
• W2095686531 cites W2068752263 @default.
• W2095686531 cites W2069785803 @default.
• W2095686531 cites W2070555090 @default.
• W2095686531 cites W2073048190 @default.
• W2095686531 cites W2073449985 @default.
• W2095686531 cites W2075682783 @default.
• W2095686531 cites W2075686321 @default.
• W2095686531 cites W2081601575 @default.
• W2095686531 cites W2085022353 @default.
• W2095686531 cites W2086130988 @default.
• W2095686531 cites W2090801856 @default.
• W2095686531 cites W2092013637 @default.
• W2095686531 cites W2101763704 @default.
• W2095686531 cites W2102572922 @default.
• W2095686531 cites W2103226055 @default.
• W2095686531 cites W2107172544 @default.
• W2095686531 cites W2107733717 @default.
• W2095686531 cites W2109330812 @default.
• W2095686531 cites W2109516757 @default.
• W2095686531 cites W2110627798 @default.
• W2095686531 cites W2115017507 @default.
• W2095686531 cites W2119576606 @default.
• W2095686531 cites W2124681501 @default.
• W2095686531 cites W2125645847 @default.
• W2095686531 cites W2128011583 @default.
• W2095686531 cites W2131800491 @default.
• W2095686531 cites W2133218279 @default.
• W2095686531 cites W2134222173 @default.
• W2095686531 cites W2134354395 @default.
• W2095686531 cites W2136739154 @default.
• W2095686531 cites W2140296969 @default.
• W2095686531 cites W2142483035 @default.
• W2095686531 cites W2148434166 @default.
• W2095686531 cites W2148553720 @default.
• W2095686531 cites W2154498815 @default.
• W2095686531 cites W2157110881 @default.
• W2095686531 cites W2159122349 @default.
• W2095686531 cites W2159340140 @default.
• W2095686531 cites W2162999713 @default.
• W2095686531 cites W2163245612 @default.
• W2095686531 cites W2166609052 @default.
• W2095686531 cites W2167840686 @default.
• W2095686531 cites W2168426067 @default.
• W2095686531 cites W2400812473 @default.
• W2095686531 cites W2582524520 @default.
• W2095686531 cites W2603308917 @default.
• W2095686531 doi "https://doi.org/10.1186/alzrt274" @default.
• W2095686531 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4255387" @default.
• W2095686531 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25484925" @default.

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