Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095693556> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2095693556 endingPage "117" @default.
- W2095693556 startingPage "111" @default.
- W2095693556 abstract "Clinically detectable splenomegaly is rarely seen in patients with non-immune chronic idiopathic neutropenia syndrome (NI-CINS). Using ultrasound, we estimated splenic volume in 52 NI-CINS patients and 14 age- and sex-matched normal controls by determining the ‘corrected splenic index’ (CSI) from the product of length, width and thickness of the organ expressed in cm3/m2 body surface area. We found that CSI was significantly higher in the group of patients compared to controls (202.8 ± 82.0 vs. 133.8 ± 28.1 cm3/m2, P=0.003), and that individual CSI values was inversely correlated with the number of circulating neutrophils (r=–0.5097, P < 0.0001). About 48.1% of the patients had CSI above 190 cm3/m2 body surface, representing the upper 95% confidence limit of values found in the controls. Patients also had increased serum concentrations of pro-inflammatory cytokines and chemokines mainly produced by activated macrophages (IL-1β, TNF-α, RANTES and IL-8), as well as increased serum levels of soluble cell adhesion molecules derived from activated endothelium (sE-Selectin, sICAM and sVCAM). We hypothesize that the increased splenic volume in NI-CINS patients may be due to the accumulation of activated macrophages inside the spleen, possibly as the result of an unrecognized low-grade chronic inflammatory process. The nature of such an inflammation is unknown. A study was designed to search for viral or bacterial genomic material in patients’ bone marrow stromal macrophages in which the unknown causal agent might be located." @default.
- W2095693556 created "2016-06-24" @default.
- W2095693556 creator A5000358758 @default.
- W2095693556 creator A5023971906 @default.
- W2095693556 creator A5038197219 @default.
- W2095693556 creator A5061797550 @default.
- W2095693556 creator A5068540445 @default.
- W2095693556 date "2001-04-22" @default.
- W2095693556 modified "2023-09-27" @default.
- W2095693556 title "Patients with non-immune chronic idiopathic neutropenia syndrome have increased splenic volume on ultrasonography" @default.
- W2095693556 cites W1964929740 @default.
- W2095693556 cites W1978927361 @default.
- W2095693556 cites W1980985809 @default.
- W2095693556 cites W1992019339 @default.
- W2095693556 cites W2000302539 @default.
- W2095693556 cites W2003051507 @default.
- W2095693556 cites W2004634355 @default.
- W2095693556 cites W2013004502 @default.
- W2095693556 cites W2018678865 @default.
- W2095693556 cites W2021156359 @default.
- W2095693556 cites W2023915186 @default.
- W2095693556 cites W2024130984 @default.
- W2095693556 cites W2024884240 @default.
- W2095693556 cites W2039716802 @default.
- W2095693556 cites W2052788412 @default.
- W2095693556 cites W2055129321 @default.
- W2095693556 cites W2065930976 @default.
- W2095693556 cites W2068153819 @default.
- W2095693556 cites W2085505444 @default.
- W2095693556 cites W2417401501 @default.
- W2095693556 cites W4230693812 @default.
- W2095693556 cites W4248237735 @default.
- W2095693556 cites W42533501 @default.
- W2095693556 cites W4253454790 @default.
- W2095693556 cites W2044172917 @default.
- W2095693556 doi "https://doi.org/10.1046/j.1365-2257.2001.00364.x" @default.
- W2095693556 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11488850" @default.
- W2095693556 hasPublicationYear "2001" @default.
- W2095693556 type Work @default.
- W2095693556 sameAs 2095693556 @default.
- W2095693556 citedByCount "7" @default.
- W2095693556 countsByYear W20956935562020 @default.
- W2095693556 crossrefType "journal-article" @default.
- W2095693556 hasAuthorship W2095693556A5000358758 @default.
- W2095693556 hasAuthorship W2095693556A5023971906 @default.
- W2095693556 hasAuthorship W2095693556A5038197219 @default.
- W2095693556 hasAuthorship W2095693556A5061797550 @default.
- W2095693556 hasAuthorship W2095693556A5068540445 @default.
- W2095693556 hasConcept C126322002 @default.
- W2095693556 hasConcept C13373296 @default.
- W2095693556 hasConcept C142724271 @default.
- W2095693556 hasConcept C203014093 @default.
- W2095693556 hasConcept C2776914184 @default.
- W2095693556 hasConcept C2780007613 @default.
- W2095693556 hasConcept C2780931953 @default.
- W2095693556 hasConcept C71924100 @default.
- W2095693556 hasConcept C8891405 @default.
- W2095693556 hasConcept C90924648 @default.
- W2095693556 hasConceptScore W2095693556C126322002 @default.
- W2095693556 hasConceptScore W2095693556C13373296 @default.
- W2095693556 hasConceptScore W2095693556C142724271 @default.
- W2095693556 hasConceptScore W2095693556C203014093 @default.
- W2095693556 hasConceptScore W2095693556C2776914184 @default.
- W2095693556 hasConceptScore W2095693556C2780007613 @default.
- W2095693556 hasConceptScore W2095693556C2780931953 @default.
- W2095693556 hasConceptScore W2095693556C71924100 @default.
- W2095693556 hasConceptScore W2095693556C8891405 @default.
- W2095693556 hasConceptScore W2095693556C90924648 @default.
- W2095693556 hasIssue "2" @default.
- W2095693556 hasLocation W20956935561 @default.
- W2095693556 hasLocation W20956935562 @default.
- W2095693556 hasOpenAccess W2095693556 @default.
- W2095693556 hasPrimaryLocation W20956935561 @default.
- W2095693556 hasRelatedWork W1542394131 @default.
- W2095693556 hasRelatedWork W1564182375 @default.
- W2095693556 hasRelatedWork W2005666125 @default.
- W2095693556 hasRelatedWork W2050374169 @default.
- W2095693556 hasRelatedWork W2081358646 @default.
- W2095693556 hasRelatedWork W2083940978 @default.
- W2095693556 hasRelatedWork W2165321096 @default.
- W2095693556 hasRelatedWork W2381635637 @default.
- W2095693556 hasRelatedWork W2416605036 @default.
- W2095693556 hasRelatedWork W4321166026 @default.
- W2095693556 hasVolume "23" @default.
- W2095693556 isParatext "false" @default.
- W2095693556 isRetracted "false" @default.
- W2095693556 magId "2095693556" @default.
- W2095693556 workType "article" @default.