FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095703604> ?p ?o ?g. }

• W2095703604 endingPage "12595" @default.
• W2095703604 startingPage "12582" @default.
• W2095703604 abstract "ABSTRACT Cell-free human immunodeficiency virus type 1 (HIV-1) can initiate infections, but contact between infected and uninfected T cells can enhance viral spread through intercellular structures called virological synapses (VS). The relative contribution of VS to cell-free viral transfer has not been carefully measured. Using an ultrasensitive, fluorescent virus transfer assay, we estimate that when VS between HIV-expressing Jurkat T cells and primary CD4 + T cells are formed, cell-associated transfer of virus is 18,000-fold more efficient than uptake of cell-free virus. Furthermore, in contrast to cell-free virus uptake, the VS deposits virus rapidly into focal, trypsin-resistant compartments in target T cells. This massive virus internalization requires Env-CD4 receptor interactions but is resistant to inhibition by patient-derived neutralizing antisera that inhibit homologous cell-free virus. Deleting the Env cytoplasmic tail does not abrogate VS-mediated transfer, but it renders the VS sensitive to neutralizing antibodies, suggesting that the tail limits exposure of VS-neutralizing epitopes on the surface of infected cells. Dynamic live imaging of the VS reveals that HIV-expressing cells are polarized and make sustained, Env-dependent contacts with target cells through uropod-like structures. The polarized T-cell morphology, Env-CD4 coordinated adhesion, and viral transfer from HIV-infected to uninfected cells suggest that VS allows HIV-1 to evade antibody neutralization and to disseminate efficiently. Future studies will discern to what extent this massive viral transfer contributes to productive infection or viral dissemination through the migration of virus-carrying T cells." @default.
• W2095703604 created "2016-06-24" @default.
• W2095703604 creator A5000126709 @default.
• W2095703604 creator A5012913900 @default.
• W2095703604 creator A5026884851 @default.
• W2095703604 creator A5055114123 @default.
• W2095703604 date "2007-11-15" @default.
• W2095703604 modified "2023-10-17" @default.
• W2095703604 title "Predominant Mode of Human Immunodeficiency Virus Transfer between T Cells Is Mediated by Sustained Env-Dependent Neutralization-Resistant Virological Synapses" @default.
• W2095703604 cites W1547027889 @default.
• W2095703604 cites W1557952727 @default.
• W2095703604 cites W1659719610 @default.
• W2095703604 cites W1966771136 @default.
• W2095703604 cites W1973398091 @default.
• W2095703604 cites W1974032982 @default.
• W2095703604 cites W1984784342 @default.
• W2095703604 cites W1986015062 @default.
• W2095703604 cites W1986865717 @default.
• W2095703604 cites W1989025673 @default.
• W2095703604 cites W1991656500 @default.
• W2095703604 cites W1992912761 @default.
• W2095703604 cites W1996684522 @default.
• W2095703604 cites W1997808475 @default.
• W2095703604 cites W1999396723 @default.
• W2095703604 cites W2004361534 @default.
• W2095703604 cites W2011630381 @default.
• W2095703604 cites W2011699290 @default.
• W2095703604 cites W2012956482 @default.
• W2095703604 cites W2013948998 @default.
• W2095703604 cites W2022098233 @default.
• W2095703604 cites W2022974362 @default.
• W2095703604 cites W2023285589 @default.
• W2095703604 cites W2023827249 @default.
• W2095703604 cites W2038211483 @default.
• W2095703604 cites W2052678796 @default.
• W2095703604 cites W2053187678 @default.
• W2095703604 cites W2056949914 @default.
• W2095703604 cites W2060139150 @default.
• W2095703604 cites W2063950143 @default.
• W2095703604 cites W2065190721 @default.
• W2095703604 cites W2069981708 @default.
• W2095703604 cites W2070607367 @default.
• W2095703604 cites W2075847325 @default.
• W2095703604 cites W2088747167 @default.
• W2095703604 cites W2095678514 @default.
• W2095703604 cites W2096966517 @default.
• W2095703604 cites W2097494814 @default.
• W2095703604 cites W2098411942 @default.
• W2095703604 cites W2099434136 @default.
• W2095703604 cites W2099491605 @default.
• W2095703604 cites W2100265029 @default.
• W2095703604 cites W2101926858 @default.
• W2095703604 cites W2104802051 @default.
• W2095703604 cites W2116786856 @default.
• W2095703604 cites W2117134676 @default.
• W2095703604 cites W2119490035 @default.
• W2095703604 cites W2127153680 @default.
• W2095703604 cites W2129515393 @default.
• W2095703604 cites W2136030671 @default.
• W2095703604 cites W2139071750 @default.
• W2095703604 cites W2143459780 @default.
• W2095703604 cites W2143666216 @default.
• W2095703604 cites W2152423604 @default.
• W2095703604 cites W2154429891 @default.
• W2095703604 cites W2161971256 @default.
• W2095703604 cites W2162703129 @default.
• W2095703604 cites W2163532764 @default.
• W2095703604 cites W2165367950 @default.
• W2095703604 cites W2166072405 @default.
• W2095703604 cites W2166678307 @default.
• W2095703604 cites W2169310292 @default.
• W2095703604 cites W2318503132 @default.
• W2095703604 cites W2318770038 @default.
• W2095703604 cites W2323021547 @default.
• W2095703604 cites W2332835113 @default.
• W2095703604 cites W2340851790 @default.
• W2095703604 doi "https://doi.org/10.1128/jvi.00381-07" @default.
• W2095703604 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2169007" @default.
• W2095703604 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17728240" @default.
• W2095703604 hasPublicationYear "2007" @default.
• W2095703604 type Work @default.
• W2095703604 sameAs 2095703604 @default.
• W2095703604 citedByCount "399" @default.
• W2095703604 countsByYear W20957036042012 @default.
• W2095703604 countsByYear W20957036042013 @default.
• W2095703604 countsByYear W20957036042014 @default.
• W2095703604 countsByYear W20957036042015 @default.
• W2095703604 countsByYear W20957036042016 @default.
• W2095703604 countsByYear W20957036042017 @default.
• W2095703604 countsByYear W20957036042018 @default.
• W2095703604 countsByYear W20957036042019 @default.
• W2095703604 countsByYear W20957036042020 @default.
• W2095703604 countsByYear W20957036042021 @default.
• W2095703604 countsByYear W20957036042022 @default.
• W2095703604 countsByYear W20957036042023 @default.
• W2095703604 crossrefType "journal-article" @default.
• W2095703604 hasAuthorship W2095703604A5000126709 @default.
• W2095703604 hasAuthorship W2095703604A5012913900 @default.

• next