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- W2095708332 abstract "Obesity is one of the major challenges to human health worldwide; however, there are currently no effective pharmacological interventions for obesity. Recent studies have improved our understanding of energy homeostasis by identifying sophisticated neurohumoral networks which convey signals between the brain and gut in order to control food intake. The hypothalamus is a key region which possesses reciprocal connections between the higher cortical centres such as reward-related limbic pathways, and the brainstem. Furthermore, the hypothalamus integrates a number of peripheral signals which modulate food intake and energy expenditure. Gut hormones, such as peptide YY, pancreatic polypeptide, glucagon-like peptide-1, oxyntomodulin, and ghrelin, are modulated by acute food ingestion. In contrast, adiposity signals such as leptin and insulin are implicated in both short- and long-term energy homeostasis. In this paper, we focus on the role of gut hormones and their related neuronal networks (the gut-brain axis) in appetite control, and their potentials as novel therapies for obesity." @default.
- W2095708332 created "2016-06-24" @default.
- W2095708332 creator A5011196462 @default.
- W2095708332 creator A5039446593 @default.
- W2095708332 creator A5072694814 @default.
- W2095708332 date "2012-01-01" @default.
- W2095708332 modified "2023-10-16" @default.
- W2095708332 title "Obesity and Appetite Control" @default.
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