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• W2095760529 abstract "K76T, a mutation in the Plasmodium falciparum chloroquine (CQ) resistance transporter protein, has been implicated in resistance to CQ. A modified 14-day in vivo test to estimate the CQ resistance level was done in southern Mozambique: 21 (42%) of 50 subjects who completed the follow-up were CQ susceptible. Use of msa2-restriction fragment length polymorphism (RFLP) genotyping to differentiate new from recrudescent infections made little difference in the estimated prevalence of resistance. The K76T mutation prevalence was estimated by RFLP-polymerase chain reaction and sequencing, and its relation to parasitological CQ resistance was explored on day 0 samples: 51 of 56 pretreatment samples presented the T76 codon, and it was present in 100% of children with parasitological resistance. T76 also was present in 18 of 23 subjects in whom the infection resolved after CQ treatment. These findings show a high prevalence of the K76T mutation among wild isolates but also suggest additional factors responsible for CQ resistance." @default.
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• W2095760529 date "2001-05-01" @default.
• W2095760529 modified "2023-10-15" @default.
• W2095760529 title "Prevalence of the K76T Mutation in the Putative<i>Plasmodium falciparum</i>Chloroquine Resistance Transporter<i>(pfcrt)</i>Gene and Its Relation to Chloroquine Resistance in Mozambique" @default.
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• W2095760529 doi "https://doi.org/10.1086/319856" @default.
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