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- W2095761131 endingPage "1713" @default.
- W2095761131 startingPage "1701" @default.
- W2095761131 abstract "Since leucine-rich repeat kinase 2 (LRRK2) was linked to Parkinson's disease in 2004, kinase activity of LRRK2 has been believed to play a critical role in the pathogenesis of Parkinson's disease. As a result, identification of LRRK2 inhibitors has been a focus for drug discovery. However, most LRRK2 mutations do not simply increase kinase activity. In this review we summarize the potential mechanisms that regulate the kinase activity of LRRK2. We outline some currently available kinase inhibitors, including the identification of a DFG-out (type-II) inhibitor. Finally, we discuss the relationship of LRRK2 with tau and α-synuclein. The fact that all three proteins are autophapgy-related provides a future strategy for the identification of LRRK2 physiological substrate(s)." @default.
- W2095761131 created "2016-06-24" @default.
- W2095761131 creator A5008742216 @default.
- W2095761131 creator A5058888670 @default.
- W2095761131 date "2012-09-01" @default.
- W2095761131 modified "2023-09-26" @default.
- W2095761131 title "Current understanding of LRRK2 in Parkinson’s disease: biochemical and structural features and inhibitor design" @default.
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- W2095761131 doi "https://doi.org/10.4155/fmc.12.110" @default.
- W2095761131 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3569718" @default.
- W2095761131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22924508" @default.
- W2095761131 hasPublicationYear "2012" @default.
- W2095761131 type Work @default.