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- W2095765891 abstract "The recent findings concerning the function of microRNAs (miRNAs) and the relationship between miRNA levels with specific disease highlight the need for miRNA detection. In this work, multi-walled carbon nanotubes (MWCNTs), having shown great potential for biosensors, were used to develop a simple, label-free, and sensitive electrochemical biosensor for detection of miRNA-24 by monitoring the oxidation signal of guanine. The synthetic DNA probes, being complementary with miRNA-24, were immobilized onto the surface of MWCNT-modified glass carbon electrodes by covalent cross-linking. The probes were hybridized with different concentrations of miRNA-24. The formed hybrids on the electrode surface were evaluated by differential pulse voltammetry. The change of guanine oxidation signal was observed as a result of the hybridization between the probes and miRNA-24. Control experiments using the non-complementary miRNA-29 were performed to evaluate the selectivity. Numerous factors affecting probe immobilization, target hybridization, and nonspecific binding events were optimized. Under the optimal conditions, the proposed miRNA-24 biosensor exhibits good sensitivity (4.963 μA cm(-2) decade(-1)), low detection limit (1 pM), and good selectivity and reproducibility. The biosensor also has acceptable recovery for miRNA-24 detection in complex miRNA sample." @default.
- W2095765891 created "2016-06-24" @default.
- W2095765891 creator A5036116945 @default.
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- W2095765891 date "2014-04-01" @default.
- W2095765891 modified "2023-10-17" @default.
- W2095765891 title "Carbon nanotube-based label-free electrochemical biosensor for sensitive detection of miRNA-24" @default.
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- W2095765891 doi "https://doi.org/10.1016/j.bios.2013.10.061" @default.
- W2095765891 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24270466" @default.
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