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• W2095767079 abstract "In blood, the transcription factor C/EBPa is essential for myeloid differentiation and has been implicated in regulating self-renewal of fetal liver haematopoietic stem cells (HSCs). However, its function in adult HSCs has remained unknown. Here, using an inducible knockout model we found that C/EBPa-deficient adult HSCs underwent a pronounced increase in number with enhanced proliferation, characteristics resembling fetal liver HSCs. Consistently, transcription profiling of C/EBPa-deficient HSCs revealed a gene expression program similar to fetal liver HSCs. Moreover, we observed that age-specific Cebpa expression correlated with its inhibitory effect on the HSC cell cycle. Mechanistically we identified N-Myc as a downstream target of C/EBPa, and loss of C/EBPa resulted in de-repression of N-Myc. Our data establish C/EBPa as a central determinant in the switch from fetal to adult HSCs." @default.
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• W2095767079 date "2013-03-17" @default.
• W2095767079 modified "2023-10-18" @default.
• W2095767079 title "C/EBPa controls acquisition and maintenance of adult haematopoietic stem cell quiescence" @default.
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• W2095767079 doi "https://doi.org/10.1038/ncb2698" @default.
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