FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095786103> ?p ?o ?g. }

• W2095786103 endingPage "1273" @default.
• W2095786103 startingPage "1266" @default.
• W2095786103 abstract "Objective:the objective of this article is to evaluate the role of siRNA-silenced TRPC6 on podocyte autophagy and apoptosis induced by AngII. Methods:mouse podocyte cell lines were cultured in vitro. The apoptosis rates of each group were detected using flow cytometry. The expression of LC3-II protein and changes in distribution were detected by confocal laser, and the western blot protocol was employed for detection of protein expression of LC3-II. Results:AngII-injured podocyte had a significant increase in apoptosis, while silencing TRPC6 could decrease the apoptosis induced by AngII. Autophagy remarkably increased after AngII injury. While silencing TRPC6 stabilized the autophagy expression, AngII could activate the autophagy of podocyte. Autophagy-associated protein LC3-II expression increased after AngII injury. The LC3-II mRNA and the protein level could be down regulated by 3-MA. The silencing of TRPC6 could stabilize the autophagy expression. Conclusion:the data suggest that AngII can lead to podocyte injury. Autophagy may have beneficial effects in preventing the progression of proteinuria. This study provides some new clues for further exploring the occurrence of podocyte injury and the development mechanism of proteinuria." @default.
• W2095786103 created "2016-06-24" @default.
• W2095786103 creator A5000007248 @default.
• W2095786103 creator A5048300323 @default.
• W2095786103 date "2014-08-20" @default.
• W2095786103 modified "2023-09-26" @default.
• W2095786103 title "The effects of siRNA-silenced TRPC6 on podocyte autophagy and apoptosis induced by AngII" @default.
• W2095786103 cites W1965916534 @default.
• W2095786103 cites W1968637251 @default.
• W2095786103 cites W1973472942 @default.
• W2095786103 cites W1974766032 @default.
• W2095786103 cites W1986081276 @default.
• W2095786103 cites W1988170371 @default.
• W2095786103 cites W1998399313 @default.
• W2095786103 cites W2012371191 @default.
• W2095786103 cites W2016040396 @default.
• W2095786103 cites W2020260798 @default.
• W2095786103 cites W2024184215 @default.
• W2095786103 cites W2026500266 @default.
• W2095786103 cites W2027817974 @default.
• W2095786103 cites W2044597685 @default.
• W2095786103 cites W2045629927 @default.
• W2095786103 cites W2057623698 @default.
• W2095786103 cites W2059500339 @default.
• W2095786103 cites W2092557822 @default.
• W2095786103 cites W2101721772 @default.
• W2095786103 cites W2108086395 @default.
• W2095786103 cites W2122529578 @default.
• W2095786103 cites W2140607131 @default.
• W2095786103 cites W2151170909 @default.
• W2095786103 cites W2165953749 @default.
• W2095786103 cites W2166039491 @default.
• W2095786103 cites W2168287443 @default.
• W2095786103 doi "https://doi.org/10.1177/1470320314543724" @default.
• W2095786103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25143325" @default.
• W2095786103 hasPublicationYear "2014" @default.
• W2095786103 type Work @default.
• W2095786103 sameAs 2095786103 @default.
• W2095786103 citedByCount "15" @default.
• W2095786103 countsByYear W20957861032015 @default.
• W2095786103 countsByYear W20957861032016 @default.
• W2095786103 countsByYear W20957861032017 @default.
• W2095786103 countsByYear W20957861032018 @default.
• W2095786103 countsByYear W20957861032019 @default.
• W2095786103 countsByYear W20957861032020 @default.
• W2095786103 countsByYear W20957861032021 @default.
• W2095786103 countsByYear W20957861032023 @default.
• W2095786103 crossrefType "journal-article" @default.
• W2095786103 hasAuthorship W2095786103A5000007248 @default.
• W2095786103 hasAuthorship W2095786103A5048300323 @default.
• W2095786103 hasBestOaLocation W20957861031 @default.
• W2095786103 hasConcept C104317684 @default.
• W2095786103 hasConcept C119056186 @default.
• W2095786103 hasConcept C128448793 @default.
• W2095786103 hasConcept C134018914 @default.
• W2095786103 hasConcept C153911025 @default.
• W2095786103 hasConcept C155164980 @default.
• W2095786103 hasConcept C170493617 @default.
• W2095786103 hasConcept C185592680 @default.
• W2095786103 hasConcept C190283241 @default.
• W2095786103 hasConcept C203522944 @default.
• W2095786103 hasConcept C2776415932 @default.
• W2095786103 hasConcept C2777146197 @default.
• W2095786103 hasConcept C2779561371 @default.
• W2095786103 hasConcept C2780091579 @default.
• W2095786103 hasConcept C502942594 @default.
• W2095786103 hasConcept C553184892 @default.
• W2095786103 hasConcept C55493867 @default.
• W2095786103 hasConcept C86803240 @default.
• W2095786103 hasConcept C95444343 @default.
• W2095786103 hasConceptScore W2095786103C104317684 @default.
• W2095786103 hasConceptScore W2095786103C119056186 @default.
• W2095786103 hasConceptScore W2095786103C128448793 @default.
• W2095786103 hasConceptScore W2095786103C134018914 @default.
• W2095786103 hasConceptScore W2095786103C153911025 @default.
• W2095786103 hasConceptScore W2095786103C155164980 @default.
• W2095786103 hasConceptScore W2095786103C170493617 @default.
• W2095786103 hasConceptScore W2095786103C185592680 @default.
• W2095786103 hasConceptScore W2095786103C190283241 @default.
• W2095786103 hasConceptScore W2095786103C203522944 @default.
• W2095786103 hasConceptScore W2095786103C2776415932 @default.
• W2095786103 hasConceptScore W2095786103C2777146197 @default.
• W2095786103 hasConceptScore W2095786103C2779561371 @default.
• W2095786103 hasConceptScore W2095786103C2780091579 @default.
• W2095786103 hasConceptScore W2095786103C502942594 @default.
• W2095786103 hasConceptScore W2095786103C553184892 @default.
• W2095786103 hasConceptScore W2095786103C55493867 @default.
• W2095786103 hasConceptScore W2095786103C86803240 @default.
• W2095786103 hasConceptScore W2095786103C95444343 @default.
• W2095786103 hasIssue "4" @default.
• W2095786103 hasLocation W20957861031 @default.
• W2095786103 hasOpenAccess W2095786103 @default.
• W2095786103 hasPrimaryLocation W20957861031 @default.
• W2095786103 hasRelatedWork W1997736718 @default.
• W2095786103 hasRelatedWork W2002675829 @default.
• W2095786103 hasRelatedWork W2022367423 @default.
• W2095786103 hasRelatedWork W2351013616 @default.
• W2095786103 hasRelatedWork W2373529589 @default.

• next