Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095803950> ?p ?o ?g. }
- W2095803950 endingPage "85" @default.
- W2095803950 startingPage "77" @default.
- W2095803950 abstract "The NF-κB (nuclear factor κB) regulator A20 antagonises IKK [IκB (inhibitor of κB) kinase] activation by modulating Lys63-linked polyubiquitination of cytokine-receptor-associated factors including TRAF2/6 (tumour-necrosis-factor-receptor-associated factor 2/6) and RIP1 (receptor-interacting protein 1). In the present paper we describe the crystal structure of the N-terminal OTU (ovarian tumour) deubiquitinase domain of A20, which differs from other deubiquitinases but shares the minimal catalytic core with otubain-2. Analysis of conserved surface regions allows prediction of ubiquitin-binding sites for the proximal and distal ubiquitin molecules. Structural and biochemical analysis suggests a novel architecture of the catalytic triad, which might be present in a subset of OTU domains including Cezanne and TRABID (TRAF-binding domain). Biochemical analysis shows a preference of the isolated A20 OTU domain for Lys48-linked tetraubiquitin in vitro suggesting that additional specificity factors might be required for the physiological function of A20 in cells." @default.
- W2095803950 created "2016-06-24" @default.
- W2095803950 creator A5086480636 @default.
- W2095803950 creator A5089377691 @default.
- W2095803950 date "2007-12-11" @default.
- W2095803950 modified "2023-09-27" @default.
- W2095803950 title "Structure of the A20 OTU domain and mechanistic insights into deubiquitination" @default.
- W2095803950 cites W1569068313 @default.
- W2095803950 cites W1982481323 @default.
- W2095803950 cites W1985469011 @default.
- W2095803950 cites W1993936200 @default.
- W2095803950 cites W1995747121 @default.
- W2095803950 cites W2003147175 @default.
- W2095803950 cites W2003742101 @default.
- W2095803950 cites W2006114349 @default.
- W2095803950 cites W2009135380 @default.
- W2095803950 cites W2013497404 @default.
- W2095803950 cites W2014540581 @default.
- W2095803950 cites W2022058405 @default.
- W2095803950 cites W2030798502 @default.
- W2095803950 cites W2043801813 @default.
- W2095803950 cites W2052908553 @default.
- W2095803950 cites W2056402897 @default.
- W2095803950 cites W2061552846 @default.
- W2095803950 cites W2070782085 @default.
- W2095803950 cites W2079204867 @default.
- W2095803950 cites W2085236616 @default.
- W2095803950 cites W2088724822 @default.
- W2095803950 cites W2091035197 @default.
- W2095803950 cites W2094362595 @default.
- W2095803950 cites W2097536945 @default.
- W2095803950 cites W2102420543 @default.
- W2095803950 cites W2109184569 @default.
- W2095803950 cites W2109609912 @default.
- W2095803950 cites W2126382353 @default.
- W2095803950 cites W2141035944 @default.
- W2095803950 cites W2144081223 @default.
- W2095803950 cites W2148119611 @default.
- W2095803950 cites W2150925238 @default.
- W2095803950 cites W4240379319 @default.
- W2095803950 doi "https://doi.org/10.1042/bj20071399" @default.
- W2095803950 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17961127" @default.
- W2095803950 hasPublicationYear "2007" @default.
- W2095803950 type Work @default.
- W2095803950 sameAs 2095803950 @default.
- W2095803950 citedByCount "163" @default.
- W2095803950 countsByYear W20958039502012 @default.
- W2095803950 countsByYear W20958039502013 @default.
- W2095803950 countsByYear W20958039502014 @default.
- W2095803950 countsByYear W20958039502015 @default.
- W2095803950 countsByYear W20958039502016 @default.
- W2095803950 countsByYear W20958039502017 @default.
- W2095803950 countsByYear W20958039502018 @default.
- W2095803950 countsByYear W20958039502019 @default.
- W2095803950 countsByYear W20958039502020 @default.
- W2095803950 countsByYear W20958039502021 @default.
- W2095803950 countsByYear W20958039502022 @default.
- W2095803950 countsByYear W20958039502023 @default.
- W2095803950 crossrefType "journal-article" @default.
- W2095803950 hasAuthorship W2095803950A5086480636 @default.
- W2095803950 hasAuthorship W2095803950A5089377691 @default.
- W2095803950 hasBestOaLocation W20958039502 @default.
- W2095803950 hasConcept C102658986 @default.
- W2095803950 hasConcept C104317684 @default.
- W2095803950 hasConcept C134459356 @default.
- W2095803950 hasConcept C25602115 @default.
- W2095803950 hasConcept C2908868211 @default.
- W2095803950 hasConcept C54355233 @default.
- W2095803950 hasConcept C6929976 @default.
- W2095803950 hasConcept C86803240 @default.
- W2095803950 hasConcept C95444343 @default.
- W2095803950 hasConceptScore W2095803950C102658986 @default.
- W2095803950 hasConceptScore W2095803950C104317684 @default.
- W2095803950 hasConceptScore W2095803950C134459356 @default.
- W2095803950 hasConceptScore W2095803950C25602115 @default.
- W2095803950 hasConceptScore W2095803950C2908868211 @default.
- W2095803950 hasConceptScore W2095803950C54355233 @default.
- W2095803950 hasConceptScore W2095803950C6929976 @default.
- W2095803950 hasConceptScore W2095803950C86803240 @default.
- W2095803950 hasConceptScore W2095803950C95444343 @default.
- W2095803950 hasIssue "1" @default.
- W2095803950 hasLocation W20958039501 @default.
- W2095803950 hasLocation W20958039502 @default.
- W2095803950 hasLocation W20958039503 @default.
- W2095803950 hasOpenAccess W2095803950 @default.
- W2095803950 hasPrimaryLocation W20958039501 @default.
- W2095803950 hasRelatedWork W1964918543 @default.
- W2095803950 hasRelatedWork W2077221868 @default.
- W2095803950 hasRelatedWork W2095693152 @default.
- W2095803950 hasRelatedWork W2134262452 @default.
- W2095803950 hasRelatedWork W2135178058 @default.
- W2095803950 hasRelatedWork W2137163764 @default.
- W2095803950 hasRelatedWork W2595475300 @default.
- W2095803950 hasRelatedWork W2604317607 @default.
- W2095803950 hasRelatedWork W4322494813 @default.
- W2095803950 hasRelatedWork W2494483005 @default.
- W2095803950 hasVolume "409" @default.
- W2095803950 isParatext "false" @default.