FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095803951> ?p ?o ?g. }

• W2095803951 endingPage "1584" @default.
• W2095803951 startingPage "1572" @default.
• W2095803951 abstract "Abstract Innervation regulates the contractile properties of vertebrate muscle fibers, in part through the effect of electrical activity on expression of distinct myosins. Herein we analyze the role of innervation in regulating the accumulation of the general, maturational, and adult forms of rodent slow myosin heavy chain (MyHC) that are defined by the presence of distinct antigenic epitopes. Denervation increases the number of fibers that express general slow MyHC, but it decreases the adult slow MyHC epitope. Cross‐reinnervation of slow muscle by a fast nerve leads to an increase in the number of fibers that express fast MyHC. In both cases, there is an increase in the number of fibers that express slow and fast IIA MyHCs, but without the adult slow MyHC epitope. The data suggest that innervation is required for maturation and maintenance of diversity of both slow and fast fibers. The sequence of slow MyHC epitope transitions is a useful biomarker, and it may play a significant role during nerve‐dependent changes in muscle fiber function. We applied this detailed muscle analysis to a transgenic mouse model of human motor and sensory neuropathy IA, also known as Charcot–Marie–Tooth disease type 1A (CMT1A), in which electrical conduction in some motor nerves is poor due to demyelination. The mice display atrophy of some muscle fibers and changes in slow and fast MyHC epitope expression, suggestive of a progressive increase in innervation of muscle fibers by fast motor neurons, even at early stages. The potential role of these early changes in disease pathogenesis is assessed. Muscle Nerve 38: 1572–1584, 2008" @default.
• W2095803951 created "2016-06-24" @default.
• W2095803951 creator A5035188778 @default.
• W2095803951 creator A5059316091 @default.
• W2095803951 creator A5080919587 @default.
• W2095803951 date "2008-11-18" @default.
• W2095803951 modified "2023-10-12" @default.
• W2095803951 title "Nerve-dependent changes in skeletal muscle myosin heavy chain after experimental denervation and cross-reinnervation and in a demyelinating mouse model of Charcot-Marie-Tooth disease type 1A" @default.
• W2095803951 cites W1514999239 @default.
• W2095803951 cites W1554571195 @default.
• W2095803951 cites W1557488126 @default.
• W2095803951 cites W1581398592 @default.
• W2095803951 cites W1588645422 @default.
• W2095803951 cites W1639798289 @default.
• W2095803951 cites W1642841590 @default.
• W2095803951 cites W1963652913 @default.
• W2095803951 cites W1966830850 @default.
• W2095803951 cites W1971206974 @default.
• W2095803951 cites W1977341238 @default.
• W2095803951 cites W1978684156 @default.
• W2095803951 cites W1991973434 @default.
• W2095803951 cites W1992511166 @default.
• W2095803951 cites W1998521558 @default.
• W2095803951 cites W2000834782 @default.
• W2095803951 cites W2003286456 @default.
• W2095803951 cites W2006636882 @default.
• W2095803951 cites W2011173742 @default.
• W2095803951 cites W2026178684 @default.
• W2095803951 cites W2028028243 @default.
• W2095803951 cites W2028954557 @default.
• W2095803951 cites W2046929994 @default.
• W2095803951 cites W2047456162 @default.
• W2095803951 cites W2052157184 @default.
• W2095803951 cites W2056224307 @default.
• W2095803951 cites W2057383945 @default.
• W2095803951 cites W2060569257 @default.
• W2095803951 cites W2062064489 @default.
• W2095803951 cites W2064513924 @default.
• W2095803951 cites W2066704736 @default.
• W2095803951 cites W2069495247 @default.
• W2095803951 cites W2071169368 @default.
• W2095803951 cites W2073388173 @default.
• W2095803951 cites W2077853923 @default.
• W2095803951 cites W2078317514 @default.
• W2095803951 cites W2079581587 @default.
• W2095803951 cites W2081252536 @default.
• W2095803951 cites W2081987235 @default.
• W2095803951 cites W2083731603 @default.
• W2095803951 cites W2085222009 @default.
• W2095803951 cites W2087211045 @default.
• W2095803951 cites W2088118528 @default.
• W2095803951 cites W2089924025 @default.
• W2095803951 cites W2093464843 @default.
• W2095803951 cites W2093734656 @default.
• W2095803951 cites W2097293027 @default.
• W2095803951 cites W2104317289 @default.
• W2095803951 cites W2106235441 @default.
• W2095803951 cites W2128716884 @default.
• W2095803951 cites W2129228740 @default.
• W2095803951 cites W2135792781 @default.
• W2095803951 cites W2137738720 @default.
• W2095803951 cites W2138744568 @default.
• W2095803951 cites W2143866689 @default.
• W2095803951 cites W2146538556 @default.
• W2095803951 cites W2158791627 @default.
• W2095803951 cites W2160341462 @default.
• W2095803951 cites W2181998936 @default.
• W2095803951 cites W2239178393 @default.
• W2095803951 cites W2316505191 @default.
• W2095803951 cites W2338212990 @default.
• W2095803951 cites W2409039696 @default.
• W2095803951 cites W286641498 @default.
• W2095803951 cites W341783850 @default.
• W2095803951 cites W4244678046 @default.
• W2095803951 doi "https://doi.org/10.1002/mus.21106" @default.
• W2095803951 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3008217" @default.
• W2095803951 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19016545" @default.
• W2095803951 hasPublicationYear "2008" @default.
• W2095803951 type Work @default.
• W2095803951 sameAs 2095803951 @default.
• W2095803951 citedByCount "17" @default.
• W2095803951 countsByYear W20958039512012 @default.
• W2095803951 countsByYear W20958039512013 @default.
• W2095803951 countsByYear W20958039512014 @default.
• W2095803951 countsByYear W20958039512015 @default.
• W2095803951 countsByYear W20958039512016 @default.
• W2095803951 countsByYear W20958039512017 @default.
• W2095803951 countsByYear W20958039512018 @default.
• W2095803951 countsByYear W20958039512020 @default.
• W2095803951 countsByYear W20958039512022 @default.
• W2095803951 countsByYear W20958039512023 @default.
• W2095803951 crossrefType "journal-article" @default.
• W2095803951 hasAuthorship W2095803951A5035188778 @default.
• W2095803951 hasAuthorship W2095803951A5059316091 @default.
• W2095803951 hasAuthorship W2095803951A5080919587 @default.
• W2095803951 hasBestOaLocation W20958039512 @default.
• W2095803951 hasConcept C104317684 @default.
• W2095803951 hasConcept C105702510 @default.

• next