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- W2095804768 abstract "Background: Unaided (“blind”) pleural biopsy is prone to sampling error and has a modest yield. We assessed the safety and yield of ultrasound (US)-assisted closed pleural biopsy in the setting of undiagnosed effusions, and investigated how pleural morphology could guide the selection and execution of closed pleural biopsy. Methods: Patients with an exudative effusion who had had a non-diagnostic thoracocentesis were prospectively stratified on imaging as having (A) an associated mass lesion (>10mm) abutting the chest wall; (B) diffuse pleural thickening (>10mm) and/or nodularity or (C) insignificant/no pleural thickening. US-assisted repeat thoracocentesis and transthoracic fine-needle aspiration (TTFNA) were performed on patients stratified to (A),and if non-diagnostic on on-site analysis, followed by a Tru-Cut biopsy. US-assisted thoracocentesis and Abrams needle biopsies were performed on all others aiming at the region(s) of interest (B) or low supra-diaphragmatic pleura (C). Results: Final diagnoses in 41 consecutive patients (30 males, 47+/-18 years) included pleural TB (n=21), malignancy (n=16) and other causes (n=4). Accurate diagnoses were obtained in 34 (82.9%) with US-assisted biopsy; thoracoscopy (n=6, 14.6%) or bronchoscopy (n=1) were required in the rest. The yield of US-assisted biopsy was higher for TB (19/21, 90.48%) than malignancy (12/16, 75.0%, p=0.37). One patient experienced mild haemoptysis following TTFNA. Conclusion: A diagnostic algorithm based on pleural morphology and US-assisted pleural biopsy has a high diagnostic yield and offers a safe first-line approach in the setting of undiagnosed pleural exudates." @default.
- W2095804768 created "2016-06-24" @default.
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- W2095804768 date "2012-09-01" @default.
- W2095804768 modified "2023-09-23" @default.
- W2095804768 title "The diagnostic yield of ultrasound-assisted closed pleural biopsy in pleural effusions following non-diagnostic thoracocentesis" @default.
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