FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095808627> ?p ?o ?g. }

• W2095808627 endingPage "219" @default.
• W2095808627 startingPage "211" @default.
• W2095808627 abstract "Alterations in skeletal muscle with heart failure contribute to exercise intolerance and physical disability. The majority of studies to date have examined abnormalities in skeletal muscle oxidative capacity and mitochondrial function. In contrast, less information is available regarding the effect of heart failure on myofibrillar protein metabolism and function. To address this issue, we examined the effect of heart failure on skeletal muscle myofibrillar protein content, isoform distribution and Ca2+ sensitivity.We measured skeletal muscle myosin heavy chain (MHC) and actin protein content and MHC isoform distribution in soleus (SOL), extensor digitorum longus (EDL), plantaris (PL) and diaphragm (DIA) muscles and myofibrillar Ca2+ sensitivity in EDL muscles from Dahl salt-sensitive rats with (high-salt fed: HS; n=10) or without heart failure (low-salt fed: LS; n=8) and assessed the relationship of these variables to markers of disease severity.No differences in muscle mass were found. Similarly, no differences in MHC (mean+/-SE; SOL: 1353+/-29 vs. 1247+/-52; EDL: 1471+/-31 vs. 1441+/-31; PL: 1207+/-66 vs. 1286+/-36; DIA: 1166+/-42 vs. 1239+/-26 AU/microg protein) or actin (EDL: 348+/-13 vs. 358+/-19; PL: 245+/-20 vs. 242+/-9; DIA: 383+/-9 vs. 376+/-17 AU/microg protein) protein content or the actin-to-MHC ratio were observed, with the exception of lower (P<0.01) actin content in the soleus of LS rats (352+/-7 vs. 310+/-8 AU/microg protein). MHC isoform expression (I, IIa, IIx, IIb) did not differ between groups in SOL (I: 89+/-1% vs. 85+/-2%; IIa: 11+/-1% vs. 15+/-2%), EDL (IIx: 43+/-10% vs. 38+/-10%; IIb: 57+/-10% vs. 62+/-10%), PL (I: 6+/-4% vs. 3+/-3%; IIa: 1+/-1% vs. 1+/-1%; IIx: 31+/-3% vs. 26+/-4%; IIb: 62+/-5% vs. 71+/-6%) or DIA (I: 43+/-6% vs. 36+/-6 %; IIa: 9+/-1% vs. 7+/-1%; IIx: 47+/-6% vs. 56+/-7%; IIb: 2+/-1% vs. 1+/-0.5%) muscles. Moreover, heart failure did not affect the Ca2+ sensitivity (i.e., pCa50) of extensor digitorum longus myofilaments (5.68+/-0.11 vs. 5.65+/-0.09). Finally, MHC and actin content, MHC isoform distribution and myofibrillar Ca2+ sensitivity were not related to markers of disease severity.Our results show that this animal model of heart failure is not characterized by alterations in the quantity or isoform distribution of key skeletal muscle myofibrillar proteins or the Ca2+ sensitivity of isometric force production. These findings suggest that alterations in skeletal muscle myofibrillar protein metabolism do not develop in parallel with myocardial failure in the Dahl salt-sensitive rat." @default.
• W2095808627 created "2016-06-24" @default.
• W2095808627 creator A5001770808 @default.
• W2095808627 creator A5034309523 @default.
• W2095808627 creator A5051231953 @default.
• W2095808627 date "2006-02-01" @default.
• W2095808627 modified "2023-10-16" @default.
• W2095808627 title "Effect of heart failure on skeletal muscle myofibrillar protein content, isoform expression and calcium sensitivity" @default.
• W2095808627 cites W1788275398 @default.
• W2095808627 cites W1981864649 @default.
• W2095808627 cites W1986242468 @default.
• W2095808627 cites W2002298697 @default.
• W2095808627 cites W2006814619 @default.
• W2095808627 cites W2009085222 @default.
• W2095808627 cites W2012657513 @default.
• W2095808627 cites W2022579740 @default.
• W2095808627 cites W2034129482 @default.
• W2095808627 cites W2036424054 @default.
• W2095808627 cites W2042284908 @default.
• W2095808627 cites W2048717364 @default.
• W2095808627 cites W2050612606 @default.
• W2095808627 cites W2061651179 @default.
• W2095808627 cites W2063561937 @default.
• W2095808627 cites W2066704736 @default.
• W2095808627 cites W2069683756 @default.
• W2095808627 cites W2077503940 @default.
• W2095808627 cites W2077758056 @default.
• W2095808627 cites W2090465644 @default.
• W2095808627 cites W2104314735 @default.
• W2095808627 cites W2109965174 @default.
• W2095808627 cites W2115263783 @default.
• W2095808627 cites W2117684251 @default.
• W2095808627 cites W2122520680 @default.
• W2095808627 cites W2124447358 @default.
• W2095808627 cites W2128652538 @default.
• W2095808627 cites W2133187260 @default.
• W2095808627 cites W2135213898 @default.
• W2095808627 cites W2139489208 @default.
• W2095808627 cites W2140313980 @default.
• W2095808627 cites W2146644604 @default.
• W2095808627 cites W2148522618 @default.
• W2095808627 cites W2158375244 @default.
• W2095808627 cites W2275247015 @default.
• W2095808627 cites W4251537082 @default.
• W2095808627 doi "https://doi.org/10.1016/j.ijcard.2005.03.024" @default.
• W2095808627 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16412799" @default.
• W2095808627 hasPublicationYear "2006" @default.
• W2095808627 type Work @default.
• W2095808627 sameAs 2095808627 @default.
• W2095808627 citedByCount "18" @default.
• W2095808627 countsByYear W20958086272012 @default.
• W2095808627 countsByYear W20958086272014 @default.
• W2095808627 countsByYear W20958086272015 @default.
• W2095808627 countsByYear W20958086272016 @default.
• W2095808627 countsByYear W20958086272022 @default.
• W2095808627 crossrefType "journal-article" @default.
• W2095808627 hasAuthorship W2095808627A5001770808 @default.
• W2095808627 hasAuthorship W2095808627A5034309523 @default.
• W2095808627 hasAuthorship W2095808627A5051231953 @default.
• W2095808627 hasConcept C104317684 @default.
• W2095808627 hasConcept C125705527 @default.
• W2095808627 hasConcept C126322002 @default.
• W2095808627 hasConcept C134018914 @default.
• W2095808627 hasConcept C185592680 @default.
• W2095808627 hasConcept C2778198053 @default.
• W2095808627 hasConcept C2779959927 @default.
• W2095808627 hasConcept C53345823 @default.
• W2095808627 hasConcept C55493867 @default.
• W2095808627 hasConcept C6997183 @default.
• W2095808627 hasConcept C71924100 @default.
• W2095808627 hasConcept C7301908 @default.
• W2095808627 hasConceptScore W2095808627C104317684 @default.
• W2095808627 hasConceptScore W2095808627C125705527 @default.
• W2095808627 hasConceptScore W2095808627C126322002 @default.
• W2095808627 hasConceptScore W2095808627C134018914 @default.
• W2095808627 hasConceptScore W2095808627C185592680 @default.
• W2095808627 hasConceptScore W2095808627C2778198053 @default.
• W2095808627 hasConceptScore W2095808627C2779959927 @default.
• W2095808627 hasConceptScore W2095808627C53345823 @default.
• W2095808627 hasConceptScore W2095808627C55493867 @default.
• W2095808627 hasConceptScore W2095808627C6997183 @default.
• W2095808627 hasConceptScore W2095808627C71924100 @default.
• W2095808627 hasConceptScore W2095808627C7301908 @default.
• W2095808627 hasIssue "2" @default.
• W2095808627 hasLocation W20958086271 @default.
• W2095808627 hasLocation W20958086272 @default.
• W2095808627 hasOpenAccess W2095808627 @default.
• W2095808627 hasPrimaryLocation W20958086271 @default.
• W2095808627 hasRelatedWork W1964009947 @default.
• W2095808627 hasRelatedWork W1977978400 @default.
• W2095808627 hasRelatedWork W1979330813 @default.
• W2095808627 hasRelatedWork W2051148260 @default.
• W2095808627 hasRelatedWork W2052610268 @default.
• W2095808627 hasRelatedWork W2106929891 @default.
• W2095808627 hasRelatedWork W2224640435 @default.
• W2095808627 hasRelatedWork W2420621720 @default.
• W2095808627 hasRelatedWork W2585093985 @default.
• W2095808627 hasRelatedWork W2914110611 @default.

• next