FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095855239> ?p ?o ?g. }

• W2095855239 endingPage "4448" @default.
• W2095855239 startingPage "4437" @default.
• W2095855239 abstract "Most axons in the CNS innervate specific subregions or layers of their target regions and form contacts with specific types of target neurons, but the molecular basis of this process is not well understood. To determine whether collapsin-1/semaphorin-III/D, a molecule known to repel specific axons, might guide afferent axons within their cerebellar targets, we characterized its expression by in situ hybridization and observed its effects on mossy and climbing fiber extension and growth cone size in vitro. In newborn mice sema-D is expressed by cerebellar Purkinje cells in parasagittal bands located medially and in some cells of the cerebellar nuclei. Later, sema-D expression in Purkinje cells broadens such that banded expression is no longer prominent, and expression is detected in progressively more lateral regions. By postnatal day 16, expression is observed throughout the cerebellar mediolateral axis. Collapsin-1 protein, the chick ortholog of sema-D, did not inhibit the extension of neurites from explants of inferior olivary nuclei, the source of climbing fibers that innervate Purkinje cells. In contrast, when it was applied to axons extending from basilar pontine explants, a source of mossy fiber afferents of granule cells, collapsin-1 caused most pontine growth cones to collapse, as evidenced by a reduction in growth cone size of up to 59%. Moreover, 63% of pontine growth cones arrested their extension or retracted. Its effects on mossy fiber extension and its distribution suggest that sema-D prevents mossy fibers from innervating inappropriate cerebellar target regions and cell types." @default.
• W2095855239 created "2016-06-24" @default.
• W2095855239 creator A5008165829 @default.
• W2095855239 creator A5008488969 @default.
• W2095855239 creator A5045608420 @default.
• W2095855239 creator A5066029339 @default.
• W2095855239 creator A5074109861 @default.
• W2095855239 creator A5077220012 @default.
• W2095855239 date "1999-06-01" @default.
• W2095855239 modified "2023-10-04" @default.
• W2095855239 title "Collapsin-1/Semaphorin-III/D Is Regulated Developmentally in Purkinje Cells and Collapses Pontocerebellar Mossy Fiber Neuronal Growth Cones" @default.
• W2095855239 cites W1000998814 @default.
• W2095855239 cites W1490037617 @default.
• W2095855239 cites W1502334285 @default.
• W2095855239 cites W1539537345 @default.
• W2095855239 cites W1545888483 @default.
• W2095855239 cites W1560358407 @default.
• W2095855239 cites W1902339921 @default.
• W2095855239 cites W1958208959 @default.
• W2095855239 cites W1965405861 @default.
• W2095855239 cites W1973150820 @default.
• W2095855239 cites W1973548001 @default.
• W2095855239 cites W1978146656 @default.
• W2095855239 cites W1987868279 @default.
• W2095855239 cites W1988958340 @default.
• W2095855239 cites W1990983421 @default.
• W2095855239 cites W1992579449 @default.
• W2095855239 cites W1992639694 @default.
• W2095855239 cites W1993043025 @default.
• W2095855239 cites W1993786495 @default.
• W2095855239 cites W1994088328 @default.
• W2095855239 cites W1994912172 @default.
• W2095855239 cites W2003766638 @default.
• W2095855239 cites W2010303364 @default.
• W2095855239 cites W2013184812 @default.
• W2095855239 cites W2021087194 @default.
• W2095855239 cites W2023193192 @default.
• W2095855239 cites W2026089486 @default.
• W2095855239 cites W2034991959 @default.
• W2095855239 cites W2035588887 @default.
• W2095855239 cites W2039153874 @default.
• W2095855239 cites W2041700814 @default.
• W2095855239 cites W2042524484 @default.
• W2095855239 cites W2043804690 @default.
• W2095855239 cites W2046034465 @default.
• W2095855239 cites W2047025165 @default.
• W2095855239 cites W2047703209 @default.
• W2095855239 cites W2049181052 @default.
• W2095855239 cites W2055444468 @default.
• W2095855239 cites W2057623849 @default.
• W2095855239 cites W2058403440 @default.
• W2095855239 cites W2059928820 @default.
• W2095855239 cites W2064173164 @default.
• W2095855239 cites W2065668335 @default.
• W2095855239 cites W2065970548 @default.
• W2095855239 cites W2066761168 @default.
• W2095855239 cites W2068599628 @default.
• W2095855239 cites W2068786393 @default.
• W2095855239 cites W2071877947 @default.
• W2095855239 cites W2074613035 @default.
• W2095855239 cites W2080642902 @default.
• W2095855239 cites W2082518857 @default.
• W2095855239 cites W2082849813 @default.
• W2095855239 cites W2083388839 @default.
• W2095855239 cites W2088158546 @default.
• W2095855239 cites W2112968518 @default.
• W2095855239 cites W2118999426 @default.
• W2095855239 cites W2124248841 @default.
• W2095855239 cites W2127439632 @default.
• W2095855239 cites W2132188266 @default.
• W2095855239 cites W2133621011 @default.
• W2095855239 cites W2187645881 @default.
• W2095855239 cites W4245552230 @default.
• W2095855239 cites W4249871697 @default.
• W2095855239 cites W4297938676 @default.
• W2095855239 doi "https://doi.org/10.1523/jneurosci.19-11-04437.1999" @default.
• W2095855239 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6782633" @default.
• W2095855239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10341245" @default.
• W2095855239 hasPublicationYear "1999" @default.
• W2095855239 type Work @default.
• W2095855239 sameAs 2095855239 @default.
• W2095855239 citedByCount "50" @default.
• W2095855239 countsByYear W20958552392013 @default.
• W2095855239 countsByYear W20958552392014 @default.
• W2095855239 countsByYear W20958552392016 @default.
• W2095855239 countsByYear W20958552392017 @default.
• W2095855239 countsByYear W20958552392021 @default.
• W2095855239 crossrefType "journal-article" @default.
• W2095855239 hasAuthorship W2095855239A5008165829 @default.
• W2095855239 hasAuthorship W2095855239A5008488969 @default.
• W2095855239 hasAuthorship W2095855239A5045608420 @default.
• W2095855239 hasAuthorship W2095855239A5066029339 @default.
• W2095855239 hasAuthorship W2095855239A5074109861 @default.
• W2095855239 hasAuthorship W2095855239A5077220012 @default.
• W2095855239 hasBestOaLocation W20958552391 @default.
• W2095855239 hasConcept C104317684 @default.
• W2095855239 hasConcept C105702510 @default.
• W2095855239 hasConcept C113246987 @default.

• next