Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095873405> ?p ?o ?g. }
- W2095873405 endingPage "27" @default.
- W2095873405 startingPage "21" @default.
- W2095873405 abstract "Arsenic trioxide (As2O3; ATO) is considered to be one of the most potent drugs in cancer chemotherapy and is highly effective in the treatment of acute promyelocytic leukemia (APL). It is well established that treatment of APL patients with ATO is associated with the disappearance of the PML-RARα fusion transcript, the characteristic APL gene product of the chromosomal translocation t(15;17). Although its mode of action is still not fully understood, ATO is known to induce cell apoptosis via generation of reactive oxygen species and activation of caspases. Several reports have indicated that ATO acts principally by inducing cell apoptosis not only in APL, but in a variety of non-APL cells including myeloma cells, chronic myeloid leukemia cells and cells of immune origin, including B or T lymphocytes, macrophages and, more recently, neutrophils. There is an increasing amount of data, including some from our laboratory, concerning the interaction between ATO and human primary cells. The focus of this review will be to cover the role of ATO in human immune primary cells with special emphasis on cells of myeloid origin. Keywords: Arsenic trioxide, monocytes, macrophages, neutrophils, apoptosis, cell signaling, cell functions" @default.
- W2095873405 created "2016-06-24" @default.
- W2095873405 creator A5005636389 @default.
- W2095873405 creator A5009082301 @default.
- W2095873405 creator A5065745826 @default.
- W2095873405 date "2009-03-01" @default.
- W2095873405 modified "2023-10-16" @default.
- W2095873405 title "Interaction Between Arsenic Trioxide and Human Primary Cells: Emphasis on Human Cells of Myeloid Origin" @default.
- W2095873405 cites W103399905 @default.
- W2095873405 cites W1484489534 @default.
- W2095873405 cites W1505133202 @default.
- W2095873405 cites W1574848475 @default.
- W2095873405 cites W1576242412 @default.
- W2095873405 cites W1585980551 @default.
- W2095873405 cites W1587537557 @default.
- W2095873405 cites W1591261382 @default.
- W2095873405 cites W1895019029 @default.
- W2095873405 cites W1932669647 @default.
- W2095873405 cites W1968683527 @default.
- W2095873405 cites W1971470223 @default.
- W2095873405 cites W1977649461 @default.
- W2095873405 cites W1979847049 @default.
- W2095873405 cites W1986340174 @default.
- W2095873405 cites W1988943440 @default.
- W2095873405 cites W1989503397 @default.
- W2095873405 cites W1998948328 @default.
- W2095873405 cites W2001881278 @default.
- W2095873405 cites W2003899579 @default.
- W2095873405 cites W2006019871 @default.
- W2095873405 cites W2013812169 @default.
- W2095873405 cites W2019016630 @default.
- W2095873405 cites W2021294789 @default.
- W2095873405 cites W2022928403 @default.
- W2095873405 cites W2039888464 @default.
- W2095873405 cites W2040911522 @default.
- W2095873405 cites W2057398639 @default.
- W2095873405 cites W2058560564 @default.
- W2095873405 cites W2061049714 @default.
- W2095873405 cites W2061907233 @default.
- W2095873405 cites W2065539371 @default.
- W2095873405 cites W2067180007 @default.
- W2095873405 cites W2070009086 @default.
- W2095873405 cites W2070227063 @default.
- W2095873405 cites W2072881421 @default.
- W2095873405 cites W2079295410 @default.
- W2095873405 cites W2082846919 @default.
- W2095873405 cites W2085343734 @default.
- W2095873405 cites W2092036624 @default.
- W2095873405 cites W2095184056 @default.
- W2095873405 cites W2101614441 @default.
- W2095873405 cites W2102174943 @default.
- W2095873405 cites W2109114226 @default.
- W2095873405 cites W2112260760 @default.
- W2095873405 cites W2122465033 @default.
- W2095873405 cites W2130975175 @default.
- W2095873405 cites W2131387743 @default.
- W2095873405 cites W2133406830 @default.
- W2095873405 cites W2135783480 @default.
- W2095873405 cites W2142423276 @default.
- W2095873405 cites W2159491267 @default.
- W2095873405 cites W2171599438 @default.
- W2095873405 cites W2341766271 @default.
- W2095873405 cites W2414934091 @default.
- W2095873405 cites W2416315125 @default.
- W2095873405 cites W130628200 @default.
- W2095873405 doi "https://doi.org/10.2174/187152809787582516" @default.
- W2095873405 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19275690" @default.
- W2095873405 hasPublicationYear "2009" @default.
- W2095873405 type Work @default.
- W2095873405 sameAs 2095873405 @default.
- W2095873405 citedByCount "13" @default.
- W2095873405 countsByYear W20958734052012 @default.
- W2095873405 countsByYear W20958734052013 @default.
- W2095873405 countsByYear W20958734052015 @default.
- W2095873405 countsByYear W20958734052016 @default.
- W2095873405 countsByYear W20958734052017 @default.
- W2095873405 crossrefType "journal-article" @default.
- W2095873405 hasAuthorship W2095873405A5005636389 @default.
- W2095873405 hasAuthorship W2095873405A5009082301 @default.
- W2095873405 hasAuthorship W2095873405A5065745826 @default.
- W2095873405 hasConcept C185592680 @default.
- W2095873405 hasConcept C190283241 @default.
- W2095873405 hasConcept C203014093 @default.
- W2095873405 hasConcept C2776601000 @default.
- W2095873405 hasConcept C2778729363 @default.
- W2095873405 hasConcept C2779282312 @default.
- W2095873405 hasConcept C2780386689 @default.
- W2095873405 hasConcept C2781121885 @default.
- W2095873405 hasConcept C502942594 @default.
- W2095873405 hasConcept C54355233 @default.
- W2095873405 hasConcept C55493867 @default.
- W2095873405 hasConcept C81885089 @default.
- W2095873405 hasConcept C86803240 @default.
- W2095873405 hasConcept C8891405 @default.
- W2095873405 hasConceptScore W2095873405C185592680 @default.
- W2095873405 hasConceptScore W2095873405C190283241 @default.
- W2095873405 hasConceptScore W2095873405C203014093 @default.
- W2095873405 hasConceptScore W2095873405C2776601000 @default.