FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095882350> ?p ?o ?g. }

• W2095882350 endingPage "164" @default.
• W2095882350 startingPage "157" @default.
• W2095882350 abstract "ObjectiveFibrosis is a major contributor to joint stiffness in osteoarthritis (OA). We investigated several factors associated with the persistence of transforming growth factor beta (TGF-β)-induced fibrosis and whether these factors also play a role in OA-related fibrosis.DesignMice were injected intra-articularly (i.a.) with an adenovirus encoding either TGF-β or connective tissue growth factor (CTGF). In addition, we induced OA by i.a. injection of bacterial collagenase into the right knee joint of C57BL/6 mice. mRNA was isolated from the synovium for Q-PCR analysis of the gene expression of various extracellular matrix (ECM) components, ECM degraders, growth factors and collagen cross-linking-related enzymes. Sections of murine knee joints injected with Ad-TGF-β or Ad-CTGF or from experimental OA were stained for lysyl hydroxylase 2 (LH2). The number of pyridinoline cross-links per triple helix collagen in synovium biopsies was determined with high-performance liquid chromatography (HPLC).ResultsExpression of collagen alpha-1(I) chain precursor (Col1a1), tissue inhibitor of metalloproteinases 1 (TIMP1) and especially procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2b (Plod2b) were highly upregulated by TGF-β but not by CTGF. Elevated expression of Plod2b mRNA was associated with high lysyl hydroxylase 2 (LH2) protein staining after TGF-β overexpression and in experimental OA. Furthermore, in experimental OA the number of hydroxypyridinoline cross-links was significant increased compared to control knee joints.ConclusionsOur data show that elevated LH2b expression is associated with the persistent nature of TGF-β-induced fibrosis. Also in experimental OA, LH2b expression as well as the number of hydroxypyridinoline cross-link were significantly upregulated. We propose that LH2b, and the subsequent increase in pyridinoline cross-links, is responsible for the persistent fibrosis in experimental OA." @default.
• W2095882350 created "2016-06-24" @default.
• W2095882350 creator A5022426954 @default.
• W2095882350 creator A5038664738 @default.
• W2095882350 creator A5045199963 @default.
• W2095882350 creator A5058446721 @default.
• W2095882350 creator A5071144290 @default.
• W2095882350 creator A5079209890 @default.
• W2095882350 creator A5083205967 @default.
• W2095882350 creator A5085509314 @default.
• W2095882350 creator A5085566811 @default.
• W2095882350 date "2013-01-01" @default.
• W2095882350 modified "2023-10-12" @default.
• W2095882350 title "Osteoarthritis-related fibrosis is associated with both elevated pyridinoline cross-link formation and lysyl hydroxylase 2b expression" @default.
• W2095882350 cites W1607676331 @default.
• W2095882350 cites W1942474822 @default.
• W2095882350 cites W1967741390 @default.
• W2095882350 cites W1979034244 @default.
• W2095882350 cites W1991602076 @default.
• W2095882350 cites W2011062520 @default.
• W2095882350 cites W2015761641 @default.
• W2095882350 cites W2017528738 @default.
• W2095882350 cites W2023752082 @default.
• W2095882350 cites W2026436601 @default.
• W2095882350 cites W2027693573 @default.
• W2095882350 cites W2041673115 @default.
• W2095882350 cites W2060928333 @default.
• W2095882350 cites W2061394329 @default.
• W2095882350 cites W2061523453 @default.
• W2095882350 cites W2063242845 @default.
• W2095882350 cites W2064345811 @default.
• W2095882350 cites W2075183184 @default.
• W2095882350 cites W2079189474 @default.
• W2095882350 cites W2087027548 @default.
• W2095882350 cites W2094064070 @default.
• W2095882350 cites W2097250275 @default.
• W2095882350 cites W2102626246 @default.
• W2095882350 cites W2103106951 @default.
• W2095882350 cites W2122808924 @default.
• W2095882350 cites W2123267249 @default.
• W2095882350 cites W2125994830 @default.
• W2095882350 cites W2131757776 @default.
• W2095882350 cites W2145999911 @default.
• W2095882350 cites W2146350838 @default.
• W2095882350 cites W2147016321 @default.
• W2095882350 cites W2151302132 @default.
• W2095882350 cites W2156056478 @default.
• W2095882350 cites W2159097703 @default.
• W2095882350 cites W2162992377 @default.
• W2095882350 cites W2169804478 @default.
• W2095882350 doi "https://doi.org/10.1016/j.joca.2012.10.002" @default.
• W2095882350 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23069856" @default.
• W2095882350 hasPublicationYear "2013" @default.
• W2095882350 type Work @default.
• W2095882350 sameAs 2095882350 @default.
• W2095882350 citedByCount "62" @default.
• W2095882350 countsByYear W20958823502013 @default.
• W2095882350 countsByYear W20958823502014 @default.
• W2095882350 countsByYear W20958823502015 @default.
• W2095882350 countsByYear W20958823502016 @default.
• W2095882350 countsByYear W20958823502017 @default.
• W2095882350 countsByYear W20958823502018 @default.
• W2095882350 countsByYear W20958823502019 @default.
• W2095882350 countsByYear W20958823502020 @default.
• W2095882350 countsByYear W20958823502021 @default.
• W2095882350 countsByYear W20958823502022 @default.
• W2095882350 countsByYear W20958823502023 @default.
• W2095882350 crossrefType "journal-article" @default.
• W2095882350 hasAuthorship W2095882350A5022426954 @default.
• W2095882350 hasAuthorship W2095882350A5038664738 @default.
• W2095882350 hasAuthorship W2095882350A5045199963 @default.
• W2095882350 hasAuthorship W2095882350A5058446721 @default.
• W2095882350 hasAuthorship W2095882350A5071144290 @default.
• W2095882350 hasAuthorship W2095882350A5079209890 @default.
• W2095882350 hasAuthorship W2095882350A5083205967 @default.
• W2095882350 hasAuthorship W2095882350A5085509314 @default.
• W2095882350 hasAuthorship W2095882350A5085566811 @default.
• W2095882350 hasBestOaLocation W20958823501 @default.
• W2095882350 hasConcept C105702510 @default.
• W2095882350 hasConcept C117961784 @default.
• W2095882350 hasConcept C118131993 @default.
• W2095882350 hasConcept C126322002 @default.
• W2095882350 hasConcept C131075544 @default.
• W2095882350 hasConcept C134018914 @default.
• W2095882350 hasConcept C142724271 @default.
• W2095882350 hasConcept C153911025 @default.
• W2095882350 hasConcept C160160445 @default.
• W2095882350 hasConcept C170493617 @default.
• W2095882350 hasConcept C181199279 @default.
• W2095882350 hasConcept C185592680 @default.
• W2095882350 hasConcept C189165786 @default.
• W2095882350 hasConcept C193143273 @default.
• W2095882350 hasConcept C204787440 @default.
• W2095882350 hasConcept C2775960820 @default.
• W2095882350 hasConcept C2776164576 @default.
• W2095882350 hasConcept C2778588143 @default.
• W2095882350 hasConcept C2779797417 @default.
• W2095882350 hasConcept C2780550940 @default.

• next