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• W2095883399 abstract "<b>1496</b> <h3><b>Objectives:</b></h3> To apply spatial covariance analysis (SCA) and voxel-based analysis of ¹⁸F-FEOBV vesicular acetylcholine transporter (VAChT) brain PET to understand the regional brain cholinergic system changes associated with REM sleep behavior disorder (RBD) in patients with Parkinson disease (PD). <h3><b>Methods:</b></h3> A total of 93 PD subjects without dementia (71M/22F; age:67.7±7.9y; modified Hoehn & Yahr stage: 2.4±0.6; duration of disease: 5.9±4.5y; MoCA total score: 26.3±3.3; MDS-UPDRS Part III total score: 32.9±12.0) underwent clinical assessment and ¹⁸F-FEOBV brain PET imaging. The presence of RBD symptoms was determined using the Mayo Sleep Questionnaire. RBD and non-RBD groups were compared using multivariate spatial covariance analysis based on the scaled subprofile model (SSM) using covariance analysis software module (http://www.nitrc.org/projects/gcva_pca/) and voxel-based independent t-test using software suite (https://www.fil.ion.ucl.ac.uk/spm/software/spm12/) on a spatially normalized parametric image. <h3><b>Results:</b></h3> Fifty PD subjects reported a history of RBD symptoms. There was no difference between the groups in term of age, disease duration, and gender. There was a borderline significant difference in Hoehn & Yahr stage (t=-1.96; p=0.0534). The subject scaling factor, a measure of overall SSM/PCA expression was significantly different between the two groups (t =-6.032; p&lt;0.0001). SSM/PCA covariance analysis showed relatively reduced VAChT binding in bilateral peri-Sylvian regions (|z|&gt;2) in the RBD compared to non-RBD group. In contrast, relatively increased binding was observed in the right putamen, bilateral anterior cingulum, and right insula in RBD subjects (|z|&gt;2). We observed similar results in a voxel-based independent t-test comparing absolute binding between the groups (uncorrected p&lt;0.01). <h3><b>Conclusions:</b></h3> Our findings identify distinct brain regions with relatively increased or decreased VAChT binding in the RBD compared to the non-RBD PD group. These bidirectional changes may represent areas of compensatory and/or degenerating cholinergic terminal changes in RBD. Areas of decreased activity may explain the increased risk of dementia in PD patients with this parasomnia." @default.
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• W2095883399 date "2010-11-04" @default.
• W2095883399 modified "2023-10-16" @default.
• W2095883399 title "Influence of distance from home to invasive centre on invasive treatment after acute coronary syndrome: a nationwide study of 24 910 patients" @default.
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• W2095883399 doi "https://doi.org/10.1136/hrt.2010.203901" @default.
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