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• W2095897941 startingPage "2249" @default.
• W2095897941 abstract "The genomes of related species contain valuable information on the history of the considered taxa. Great apes in particular exhibit variation of evolutionary patterns along their genomes. However, the great ape data also bring new challenges, such as the presence of incomplete lineage sorting and ancestral shared polymorphisms. Previous methods for genome-scale analysis are restricted to very few individuals or cannot disentangle the contribution of mutation rates and fixation biases. This represents a limitation both for the understanding of these forces as well as for the detection of regions affected by selection. Here, we present a new model designed to estimate mutation rates and fixation biases from genetic variation within and between species. We relax the assumption of instantaneous substitutions, modeling substitutions as mutational events followed by a gradual fixation. Hence, we straightforwardly account for shared ancestral polymorphisms and incomplete lineage sorting. We analyze genome-wide synonymous site alignments of human, chimpanzee, and two orangutan species. From each taxon, we include data from several individuals. We estimate mutation rates and GC-biased gene conversion intensity. We find that both mutation rates and biased gene conversion vary with GC content. We also find lineage-specific differences, with weaker fixation biases in orangutan species, suggesting a reduced historical effective population size. Finally, our results are consistent with directional selection acting on coding sequences in relation to exonic splicing enhancers." @default.
• W2095897941 created "2016-06-24" @default.
• W2095897941 creator A5006598290 @default.
• W2095897941 creator A5038278389 @default.
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• W2095897941 date "2013-08-01" @default.
• W2095897941 modified "2023-09-25" @default.
• W2095897941 title "Linking Great Apes Genome Evolution across Time Scales Using Polymorphism-Aware Phylogenetic Models" @default.
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• W2095897941 doi "https://doi.org/10.1093/molbev/mst131" @default.
• W2095897941 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3773373" @default.
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• W2095897941 hasPublicationYear "2013" @default.
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