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• W2095903770 abstract "An appreciable fraction of introns is thought to have some function, but there is no obvious way to predict which specific intron is likely to be functional. We hypothesize that functional introns experience a different selection regime than non-functional ones and will therefore show distinct evolutionary histories. In particular, we expect functional introns to be more resistant to loss, and that this would be reflected in high conservation of their position with respect to the coding sequence. To test this hypothesis, we focused on introns whose function comes about from microRNAs and snoRNAs that are embedded within their sequence. We built a data set of orthologous genes across 28 eukaryotic species, reconstructed the evolutionary histories of their introns and compared functional introns with the rest of the introns. We found that, indeed, the position of microRNA- and snoRNA-bearing introns is significantly more conserved. In addition, we found that both families of RNA genes settled within introns early during metazoan evolution. We identified several easily computable intronic properties that can be used to detect functional introns in general, thereby suggesting a new strategy to pinpoint non-coding cellular functions." @default.
• W2095903770 created "2016-06-24" @default.
• W2095903770 creator A5023081891 @default.
• W2095903770 creator A5025997249 @default.
• W2095903770 date "2013-04-19" @default.
• W2095903770 modified "2023-09-27" @default.
• W2095903770 title "Computational identification of functional introns: high positional conservation of introns that harbor RNA genes" @default.
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• W2095903770 doi "https://doi.org/10.1093/nar/gkt244" @default.
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