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• W2095938336 endingPage "4297" @default.
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• W2095938336 abstract "G-protein-coupled inwardly rectifying K + channels (Kir3 channels) coupled to metabotropic GABA B receptors are essential for the control of neuronal excitation. To determine the distribution of Kir3 channels and their spatial relationship to GABA B receptors on hippocampal pyramidal cells, we used a high-resolution immunocytochemical approach. Immunoreactivity for the Kir3.2 subunit was most abundant postsynaptically and localized to the extrasynaptic plasma membrane of dendritic shafts and spines of principal cells. Quantitative analysis of immunogold particles for Kir3.2 revealed an enrichment of the protein around putative glutamatergic synapses on dendritic spines, similar to that of GABA B1 . Consistent with this observation, a high degree of coclustering of Kir3.2 and GABA B1 was revealed around excitatory synapses by the highly sensitive SDS-digested freeze–fracture replica immunolabeling. In contrast, in dendritic shafts receptors and channels were found to be mainly segregated. These results suggest that Kir3.2-containing K + channels on dendritic spines preferentially mediate the effect of GABA, whereas channels on dendritic shafts are likely to be activated by other neurotransmitters as well. Thus, Kir3 channels, localized to different subcellular compartments of hippocampal principal cells, appear to be differentially involved in synaptic integration in pyramidal cell dendrites." @default.
• W2095938336 created "2016-06-24" @default.
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• W2095938336 date "2006-04-19" @default.
• W2095938336 modified "2023-10-16" @default.
• W2095938336 title "Compartment-Dependent Colocalization of Kir3.2-Containing K⁺Channels and GABA_BReceptors in Hippocampal Pyramidal Cells" @default.
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• W2095938336 doi "https://doi.org/10.1523/jneurosci.4178-05.2006" @default.
• W2095938336 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6673994" @default.
• W2095938336 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16624949" @default.
• W2095938336 hasPublicationYear "2006" @default.
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