Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095943660> ?p ?o ?g. }
- W2095943660 abstract "Fertilization of sea urchin eggs involves an increase in protein synthesis associated with a decrease in the amount of the translation initiation inhibitor 4E-BP. A highly simple reaction model for the regulation of protein synthesis was built and was used to simulate the physiological changes in the total 4E-BP amount observed during time after fertilization. Our study evidenced that two changes occurring at fertilization are necessary to fit with experimental data. The first change was an 8-fold increase in the dissociation parameter (koff1) of the eIF4E:4E-BP complex. The second was an important 32.5-fold activation of the degradation mechanism of the protein 4E-BP. Additionally, the changes in both processes should occur in 5 min time interval post-fertilization. To validate the model, we checked that the kinetic of the predicted 4.2-fold increase of eIF4E:eIF4G complex concentration at fertilization matched the increase of protein synthesis experimentally observed after fertilization (6.6-fold, SD = 2.3, n = 8). The minimal model was also used to simulate changes observed after fertilization in the presence of rapamycin, a FRAP/mTOR inhibitor. The model showed that the eIF4E:4E-BP complex destabilization was impacted and surprisingly, that the mechanism of 4E-BP degradation was also strongly affected, therefore suggesting that both processes are controlled by the protein kinase FRAP/mTOR." @default.
- W2095943660 created "2016-06-24" @default.
- W2095943660 creator A5014458386 @default.
- W2095943660 creator A5023072115 @default.
- W2095943660 creator A5023269406 @default.
- W2095943660 creator A5037413740 @default.
- W2095943660 creator A5051231551 @default.
- W2095943660 creator A5063755415 @default.
- W2095943660 creator A5070220291 @default.
- W2095943660 creator A5072525622 @default.
- W2095943660 creator A5076785744 @default.
- W2095943660 creator A5082953016 @default.
- W2095943660 creator A5084243464 @default.
- W2095943660 date "2014-05-06" @default.
- W2095943660 modified "2023-10-05" @default.
- W2095943660 title "Modelization of the regulation of protein synthesis following fertilization in sea urchin shows requirement of two processes: a destabilization of eIF4E:4E-BP complex and a great stimulation of the 4E-BP-degradation mechanism, both rapamycin-sensitive" @default.
- W2095943660 cites W1607579928 @default.
- W2095943660 cites W1964567262 @default.
- W2095943660 cites W1965756219 @default.
- W2095943660 cites W1971739920 @default.
- W2095943660 cites W1981001162 @default.
- W2095943660 cites W1994435808 @default.
- W2095943660 cites W1998374160 @default.
- W2095943660 cites W2008205388 @default.
- W2095943660 cites W2008410413 @default.
- W2095943660 cites W2012005152 @default.
- W2095943660 cites W2018335700 @default.
- W2095943660 cites W2035016947 @default.
- W2095943660 cites W2035130062 @default.
- W2095943660 cites W2037532701 @default.
- W2095943660 cites W2048083639 @default.
- W2095943660 cites W2053304186 @default.
- W2095943660 cites W2055308216 @default.
- W2095943660 cites W2061252872 @default.
- W2095943660 cites W2064083322 @default.
- W2095943660 cites W2064773855 @default.
- W2095943660 cites W2080828132 @default.
- W2095943660 cites W2081074418 @default.
- W2095943660 cites W2092835016 @default.
- W2095943660 cites W2096671082 @default.
- W2095943660 cites W2097627476 @default.
- W2095943660 cites W2099136664 @default.
- W2095943660 cites W2110932995 @default.
- W2095943660 cites W2118598410 @default.
- W2095943660 cites W2119510512 @default.
- W2095943660 cites W2157497892 @default.
- W2095943660 cites W2160079255 @default.
- W2095943660 cites W2163382569 @default.
- W2095943660 cites W2164465342 @default.
- W2095943660 cites W39553051 @default.
- W2095943660 cites W86541428 @default.
- W2095943660 doi "https://doi.org/10.3389/fgene.2014.00117" @default.
- W2095943660 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4018528" @default.
- W2095943660 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24834072" @default.
- W2095943660 hasPublicationYear "2014" @default.
- W2095943660 type Work @default.
- W2095943660 sameAs 2095943660 @default.
- W2095943660 citedByCount "8" @default.
- W2095943660 countsByYear W20959436602015 @default.
- W2095943660 countsByYear W20959436602016 @default.
- W2095943660 countsByYear W20959436602018 @default.
- W2095943660 countsByYear W20959436602019 @default.
- W2095943660 countsByYear W20959436602022 @default.
- W2095943660 crossrefType "journal-article" @default.
- W2095943660 hasAuthorship W2095943660A5014458386 @default.
- W2095943660 hasAuthorship W2095943660A5023072115 @default.
- W2095943660 hasAuthorship W2095943660A5023269406 @default.
- W2095943660 hasAuthorship W2095943660A5037413740 @default.
- W2095943660 hasAuthorship W2095943660A5051231551 @default.
- W2095943660 hasAuthorship W2095943660A5063755415 @default.
- W2095943660 hasAuthorship W2095943660A5070220291 @default.
- W2095943660 hasAuthorship W2095943660A5072525622 @default.
- W2095943660 hasAuthorship W2095943660A5076785744 @default.
- W2095943660 hasAuthorship W2095943660A5082953016 @default.
- W2095943660 hasAuthorship W2095943660A5084243464 @default.
- W2095943660 hasBestOaLocation W20959436601 @default.
- W2095943660 hasConcept C104317684 @default.
- W2095943660 hasConcept C105580179 @default.
- W2095943660 hasConcept C12554922 @default.
- W2095943660 hasConcept C149364088 @default.
- W2095943660 hasConcept C161295673 @default.
- W2095943660 hasConcept C184235292 @default.
- W2095943660 hasConcept C185592680 @default.
- W2095943660 hasConcept C2776908312 @default.
- W2095943660 hasConcept C2992195973 @default.
- W2095943660 hasConcept C3675279 @default.
- W2095943660 hasConcept C54355233 @default.
- W2095943660 hasConcept C55493867 @default.
- W2095943660 hasConcept C86803240 @default.
- W2095943660 hasConcept C88972607 @default.
- W2095943660 hasConcept C95444343 @default.
- W2095943660 hasConcept C97029542 @default.
- W2095943660 hasConceptScore W2095943660C104317684 @default.
- W2095943660 hasConceptScore W2095943660C105580179 @default.
- W2095943660 hasConceptScore W2095943660C12554922 @default.
- W2095943660 hasConceptScore W2095943660C149364088 @default.
- W2095943660 hasConceptScore W2095943660C161295673 @default.
- W2095943660 hasConceptScore W2095943660C184235292 @default.
- W2095943660 hasConceptScore W2095943660C185592680 @default.
- W2095943660 hasConceptScore W2095943660C2776908312 @default.