FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095953301> ?p ?o ?g. }

• W2095953301 endingPage "1000" @default.
• W2095953301 startingPage "990" @default.
• W2095953301 abstract "ABSTRACT In response to genotoxic stress, ATR and ATM kinases phosphorylate H2A in fungi and H2AX in animals on a C-terminal serine. The resulting modified histone, called γH2A, recruits chromatin-binding proteins that stabilize stalled replication forks or promote DNA double-strand-break repair. To identify genomic loci that might be prone to replication fork stalling or DNA breakage in Neurospora crassa , we performed chromatin immunoprecipitation (ChIP) of γH2A followed by next-generation sequencing (ChIP-seq). γH2A-containing nucleosomes are enriched in Neurospora heterochromatin domains. These domains are comprised of A·T-rich repetitive DNA sequences associated with histone H3 methylated at lysine-9 (H3K9me), the H3K9me-binding protein heterochromatin protein 1 (HP1), and DNA cytosine methylation. H3K9 methylation, catalyzed by DIM-5, is required for normal γH2A localization. In contrast, γH2A is not required for H3K9 methylation or DNA methylation. Normal γH2A localization also depends on HP1 and a histone deacetylase, HDA-1, but is independent of the DNA methyltransferase DIM-2. γH2A is globally induced in dim-5 mutants under normal growth conditions, suggesting that the DNA damage response is activated in these mutants in the absence of exogenous DNA damage. Together, these data suggest that heterochromatin formation is essential for normal DNA replication or repair." @default.
• W2095953301 created "2016-06-24" @default.
• W2095953301 creator A5002922226 @default.
• W2095953301 creator A5004503059 @default.
• W2095953301 creator A5007776550 @default.
• W2095953301 creator A5047982881 @default.
• W2095953301 creator A5067761628 @default.
• W2095953301 creator A5085459045 @default.
• W2095953301 date "2014-08-01" @default.
• W2095953301 modified "2023-10-01" @default.
• W2095953301 title "Heterochromatin Controls γH2A Localization in Neurospora crassa" @default.
• W2095953301 cites W1518422217 @default.
• W2095953301 cites W1528728961 @default.
• W2095953301 cites W1541295792 @default.
• W2095953301 cites W1564224574 @default.
• W2095953301 cites W1730776587 @default.
• W2095953301 cites W1967244060 @default.
• W2095953301 cites W1970814720 @default.
• W2095953301 cites W1976242374 @default.
• W2095953301 cites W1981259598 @default.
• W2095953301 cites W1982134344 @default.
• W2095953301 cites W1983300263 @default.
• W2095953301 cites W1985775217 @default.
• W2095953301 cites W1990672687 @default.
• W2095953301 cites W1992763575 @default.
• W2095953301 cites W2008067403 @default.
• W2095953301 cites W2011068062 @default.
• W2095953301 cites W2018873573 @default.
• W2095953301 cites W2019322000 @default.
• W2095953301 cites W2019405732 @default.
• W2095953301 cites W2019907427 @default.
• W2095953301 cites W2021341670 @default.
• W2095953301 cites W2026335303 @default.
• W2095953301 cites W2026887719 @default.
• W2095953301 cites W2029369774 @default.
• W2095953301 cites W2030632688 @default.
• W2095953301 cites W2033828311 @default.
• W2095953301 cites W2037606715 @default.
• W2095953301 cites W2037607661 @default.
• W2095953301 cites W2038784088 @default.
• W2095953301 cites W2040248068 @default.
• W2095953301 cites W2040860750 @default.
• W2095953301 cites W2041454467 @default.
• W2095953301 cites W2041656651 @default.
• W2095953301 cites W2045504097 @default.
• W2095953301 cites W2048971231 @default.
• W2095953301 cites W2052770408 @default.
• W2095953301 cites W2054923018 @default.
• W2095953301 cites W2056073143 @default.
• W2095953301 cites W2056375209 @default.
• W2095953301 cites W2057185906 @default.
• W2095953301 cites W2060505007 @default.
• W2095953301 cites W2061795391 @default.
• W2095953301 cites W2067080454 @default.
• W2095953301 cites W2070660722 @default.
• W2095953301 cites W2072139119 @default.
• W2095953301 cites W2073031217 @default.
• W2095953301 cites W2076494331 @default.
• W2095953301 cites W2081608088 @default.
• W2095953301 cites W2084089807 @default.
• W2095953301 cites W2086441273 @default.
• W2095953301 cites W2089817610 @default.
• W2095953301 cites W2090079179 @default.
• W2095953301 cites W2090571513 @default.
• W2095953301 cites W2090996404 @default.
• W2095953301 cites W2094473285 @default.
• W2095953301 cites W2097360161 @default.
• W2095953301 cites W2097822523 @default.
• W2095953301 cites W2102619694 @default.
• W2095953301 cites W2112170782 @default.
• W2095953301 cites W2113919991 @default.
• W2095953301 cites W2117131162 @default.
• W2095953301 cites W2122680160 @default.
• W2095953301 cites W2128829232 @default.
• W2095953301 cites W2132330275 @default.
• W2095953301 cites W2134179374 @default.
• W2095953301 cites W2135404147 @default.
• W2095953301 cites W2136145671 @default.
• W2095953301 cites W2139415415 @default.
• W2095953301 cites W2144268209 @default.
• W2095953301 cites W2146047594 @default.
• W2095953301 cites W2148889490 @default.
• W2095953301 cites W2150587707 @default.
• W2095953301 cites W2155419616 @default.
• W2095953301 cites W2159860718 @default.
• W2095953301 cites W2160336344 @default.
• W2095953301 cites W2160444236 @default.
• W2095953301 cites W2162001075 @default.
• W2095953301 cites W2167227807 @default.
• W2095953301 cites W2167493116 @default.
• W2095953301 cites W2167984230 @default.
• W2095953301 cites W2168909179 @default.
• W2095953301 cites W2170551349 @default.
• W2095953301 cites W2170776600 @default.
• W2095953301 cites W3211005720 @default.
• W2095953301 doi "https://doi.org/10.1128/ec.00117-14" @default.
• W2095953301 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4135800" @default.
• W2095953301 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24879124" @default.

• next