FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095960897> ?p ?o ?g. }

• W2095960897 endingPage "3729" @default.
• W2095960897 startingPage "3721" @default.
• W2095960897 abstract "Blockade of IL-2R with humanized anti-CD25 Abs, such as daclizumab, inhibits Th2 responses in human T cells. Recent murine studies have shown that IL-2 also plays a significant role in regulating Th2 cell differentiation by activated STAT5. To explore the role of activated STAT5 in the Th2 differentiation of primary human T cells, we studied the mechanisms underlying IL-2 regulation of C-MAF expression. Chromatin immunoprecipitation studies revealed that IL-2 induced STAT5 binding to specific sites in the C-MAF promoter. These sites corresponded to regions enriched for markers of chromatin architectural features in both resting CD4 and differentiated Th2 cells. Unlike IL-6, IL-2 induced C-MAF expression in CD4 T cells with or without prior TCR stimulation. TCR-induced C-MAF expression was significantly inhibited by treatment with daclizumab or a JAK3 inhibitor, R333. Furthermore, IL-2 and IL-6 synergistically induced C-MAF expression in TCR-activated T cells, suggesting functional cooperation between these cytokines. Finally, both TCR-induced early IL4 mRNA expression and IL-4 cytokine expression in differentiated Th2 cells were significantly inhibited by IL-2R blockade. Thus, our findings demonstrate the importance of IL-2 in Th2 differentiation in human T cells and support the notion that IL-2R-directed therapies may have utility in the treatment of allergic disorders." @default.
• W2095960897 created "2016-06-24" @default.
• W2095960897 creator A5008486711 @default.
• W2095960897 creator A5013904751 @default.
• W2095960897 creator A5023940630 @default.
• W2095960897 creator A5035864541 @default.
• W2095960897 creator A5038689528 @default.
• W2095960897 creator A5042602459 @default.
• W2095960897 creator A5044647468 @default.
• W2095960897 creator A5047828651 @default.
• W2095960897 creator A5051662657 @default.
• W2095960897 creator A5053772257 @default.
• W2095960897 creator A5060228610 @default.
• W2095960897 creator A5073149983 @default.
• W2095960897 creator A5078954456 @default.
• W2095960897 creator A5086237607 @default.
• W2095960897 date "2011-10-01" @default.
• W2095960897 modified "2023-10-14" @default.
• W2095960897 title "IL-2 Regulates Expression of <i>C-MAF</i> in Human CD4 T Cells" @default.
• W2095960897 cites W1515237957 @default.
• W2095960897 cites W1568092857 @default.
• W2095960897 cites W1603378909 @default.
• W2095960897 cites W1821858011 @default.
• W2095960897 cites W1878828051 @default.
• W2095960897 cites W1918737925 @default.
• W2095960897 cites W1947099084 @default.
• W2095960897 cites W1963518763 @default.
• W2095960897 cites W1968924661 @default.
• W2095960897 cites W1973603971 @default.
• W2095960897 cites W1974595919 @default.
• W2095960897 cites W1986266083 @default.
• W2095960897 cites W1988707760 @default.
• W2095960897 cites W1990827391 @default.
• W2095960897 cites W1993426597 @default.
• W2095960897 cites W1995957006 @default.
• W2095960897 cites W2000049562 @default.
• W2095960897 cites W2004068229 @default.
• W2095960897 cites W2004368096 @default.
• W2095960897 cites W2013495037 @default.
• W2095960897 cites W2014787267 @default.
• W2095960897 cites W2015197479 @default.
• W2095960897 cites W2015416439 @default.
• W2095960897 cites W2022110934 @default.
• W2095960897 cites W2033534274 @default.
• W2095960897 cites W2043043717 @default.
• W2095960897 cites W2052006922 @default.
• W2095960897 cites W2059189469 @default.
• W2095960897 cites W2062267397 @default.
• W2095960897 cites W2072968746 @default.
• W2095960897 cites W2086448038 @default.
• W2095960897 cites W2087573417 @default.
• W2095960897 cites W2092390808 @default.
• W2095960897 cites W2094096693 @default.
• W2095960897 cites W2102304447 @default.
• W2095960897 cites W2108455002 @default.
• W2095960897 cites W2119802871 @default.
• W2095960897 cites W2121251204 @default.
• W2095960897 cites W2128181270 @default.
• W2095960897 cites W2131460312 @default.
• W2095960897 cites W2136672328 @default.
• W2095960897 cites W2147541651 @default.
• W2095960897 cites W2162102331 @default.
• W2095960897 cites W2167704621 @default.
• W2095960897 doi "https://doi.org/10.4049/jimmunol.1002354" @default.
• W2095960897 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3432901" @default.
• W2095960897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21876034" @default.
• W2095960897 hasPublicationYear "2011" @default.
• W2095960897 type Work @default.
• W2095960897 sameAs 2095960897 @default.
• W2095960897 citedByCount "25" @default.
• W2095960897 countsByYear W20959608972012 @default.
• W2095960897 countsByYear W20959608972013 @default.
• W2095960897 countsByYear W20959608972014 @default.
• W2095960897 countsByYear W20959608972015 @default.
• W2095960897 countsByYear W20959608972016 @default.
• W2095960897 countsByYear W20959608972017 @default.
• W2095960897 countsByYear W20959608972018 @default.
• W2095960897 countsByYear W20959608972019 @default.
• W2095960897 countsByYear W20959608972020 @default.
• W2095960897 countsByYear W20959608972021 @default.
• W2095960897 countsByYear W20959608972022 @default.
• W2095960897 countsByYear W20959608972023 @default.
• W2095960897 crossrefType "journal-article" @default.
• W2095960897 hasAuthorship W2095960897A5008486711 @default.
• W2095960897 hasAuthorship W2095960897A5013904751 @default.
• W2095960897 hasAuthorship W2095960897A5023940630 @default.
• W2095960897 hasAuthorship W2095960897A5035864541 @default.
• W2095960897 hasAuthorship W2095960897A5038689528 @default.
• W2095960897 hasAuthorship W2095960897A5042602459 @default.
• W2095960897 hasAuthorship W2095960897A5044647468 @default.
• W2095960897 hasAuthorship W2095960897A5047828651 @default.
• W2095960897 hasAuthorship W2095960897A5051662657 @default.
• W2095960897 hasAuthorship W2095960897A5053772257 @default.
• W2095960897 hasAuthorship W2095960897A5060228610 @default.
• W2095960897 hasAuthorship W2095960897A5073149983 @default.
• W2095960897 hasAuthorship W2095960897A5078954456 @default.
• W2095960897 hasAuthorship W2095960897A5086237607 @default.
• W2095960897 hasBestOaLocation W20959608971 @default.

• next