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• W2095967048 endingPage "413" @default.
• W2095967048 startingPage "406" @default.
• W2095967048 abstract "A hallmark feature of several pathogenic microbes is the distinctive color of their colonies when propagated in the clinical laboratory. Such pigmentation comes in a variety of hues, and has often proven useful in presumptive clinical diagnosis. Recent advances in microbial pigment biochemistry and the genetic basis of pigment production have sometimes revealed a more sinister aspect to these curious materials that change the color of reflected light by selective light absorbance. In many cases, the microbial pigment contributes to disease pathogenesis by interfering with host immune clearance mechanisms or by exhibiting pro-inflammatory or cytotoxic properties. We review several examples of pigments that promote microbial virulence, including the golden staphyloxanthin of Staphylococcusaureus, the blue-green pyocyanin of Pseudomonas spp., and the dark brown or black melanin pigments of Cryptococcus neoformans and Aspergillus spp. Targeted pigment neutralisation might represent a viable concept to enhance treatment of certain difficult infectious disease conditions." @default.
• W2095967048 created "2016-06-24" @default.
• W2095967048 creator A5067852918 @default.
• W2095967048 creator A5070330260 @default.
• W2095967048 date "2009-09-01" @default.
• W2095967048 modified "2023-10-10" @default.
• W2095967048 title "Color me bad: microbial pigments as virulence factors" @default.
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• W2095967048 doi "https://doi.org/10.1016/j.tim.2009.06.006" @default.

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