FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095974206> ?p ?o ?g. }

• W2095974206 endingPage "799" @default.
• W2095974206 startingPage "789" @default.
• W2095974206 abstract "Previous studies have established the presence of high numbers of activated T lymphocytes and aberrant expression of major histocompatibility complex class II antigens by endothelial and smooth muscle cells in human atherosclerotic lesions, implicating the involvement of a local cellular immune response. The identity of the antigen(s) eliciting this immune response, the extent of their effect, and the atherogenic stage at which they occur remain to be determined. In the present studies, 120 normocholesterolemic New Zealand White rabbits were immunized one or more times with various antigens, with or without adjuvants. The antigens and adjuvants included human or rabbit atherosclerotic lesion proteins, ovalbumin, Freund's complete and/or incomplete adjuvants, recombinant mycobacterial heat shock protein 65 (hsp65), and two hsp-free adjuvants, Ribi complete adjuvant and lipopeptide. In addition, some groups received a high-cholesterol diet. Sixteen weeks after the first immunization the animals were killed, and arteriosclerotic lesions in the intima of the aortic arch were found to have developed only in those animals immunized with antigenic preparations containing hsp, either in the form of whole mycobacteria or as purified recombinant hsp65, although their serum cholesterol levels were normal. No arteriosclerotic changes exceeding those of controls were found in the other groups, irrespective of the antigen used. Immunohistopathologic examination revealed that the lesions contained 20% T cells, 10-30% macrophages, and 10-40% smooth muscle cells. Analysis of the peripheral blood T-lymphocyte proliferative responses revealed that the occurrence of lesions was positively correlated with the presence of hsp65-reactive T cells, suggesting that hsp65 is involved in the induction of arteriosclerotic lesions. Furthermore, combined immunization with hsp-containing material and a cholesterol-rich diet provoked development of significantly more severe atherosclerosis and the appearance of characteristic foam cells. We conclude that an (auto)immune response to hsp may initiate the development of atherosclerosis and that a high blood cholesterol level is only one albeit a very important risk factor." @default.
• W2095974206 created "2016-06-24" @default.
• W2095974206 creator A5004343721 @default.
• W2095974206 creator A5007001229 @default.
• W2095974206 creator A5017098768 @default.
• W2095974206 creator A5022068141 @default.
• W2095974206 creator A5022101190 @default.
• W2095974206 creator A5034145989 @default.
• W2095974206 creator A5077723411 @default.
• W2095974206 creator A5080534060 @default.
• W2095974206 date "1992-07-01" @default.
• W2095974206 modified "2023-10-10" @default.
• W2095974206 title "Induction of arteriosclerosis in normocholesterolemic rabbits by immunization with heat shock protein 65." @default.
• W2095974206 cites W1512443712 @default.
• W2095974206 cites W152815097 @default.
• W2095974206 cites W1530257476 @default.
• W2095974206 cites W1602113709 @default.
• W2095974206 cites W165426504 @default.
• W2095974206 cites W173700730 @default.
• W2095974206 cites W1954689247 @default.
• W2095974206 cites W1962075410 @default.
• W2095974206 cites W1977717029 @default.
• W2095974206 cites W1977778060 @default.
• W2095974206 cites W1994905572 @default.
• W2095974206 cites W1997296018 @default.
• W2095974206 cites W2008273006 @default.
• W2095974206 cites W2008351843 @default.
• W2095974206 cites W2020708638 @default.
• W2095974206 cites W2022721580 @default.
• W2095974206 cites W2024352183 @default.
• W2095974206 cites W2032207767 @default.
• W2095974206 cites W2033246567 @default.
• W2095974206 cites W2035720710 @default.
• W2095974206 cites W2040311137 @default.
• W2095974206 cites W2050795431 @default.
• W2095974206 cites W20509213 @default.
• W2095974206 cites W2061755142 @default.
• W2095974206 cites W2063652189 @default.
• W2095974206 cites W2070854264 @default.
• W2095974206 cites W2072524667 @default.
• W2095974206 cites W2074977347 @default.
• W2095974206 cites W2079289760 @default.
• W2095974206 cites W2081681953 @default.
• W2095974206 cites W2086570977 @default.
• W2095974206 cites W2102686209 @default.
• W2095974206 cites W2114631256 @default.
• W2095974206 cites W2122573572 @default.
• W2095974206 cites W2154361055 @default.
• W2095974206 cites W2164142607 @default.
• W2095974206 cites W2247577406 @default.
• W2095974206 cites W227206602 @default.
• W2095974206 cites W2287249297 @default.
• W2095974206 cites W2295035781 @default.
• W2095974206 cites W2396356772 @default.
• W2095974206 cites W2397988498 @default.
• W2095974206 cites W2430326674 @default.
• W2095974206 cites W327500090 @default.
• W2095974206 cites W335324448 @default.
• W2095974206 doi "https://doi.org/10.1161/01.atv.12.7.789" @default.
• W2095974206 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1616904" @default.
• W2095974206 hasPublicationYear "1992" @default.
• W2095974206 type Work @default.
• W2095974206 sameAs 2095974206 @default.
• W2095974206 citedByCount "333" @default.
• W2095974206 countsByYear W20959742062012 @default.
• W2095974206 countsByYear W20959742062013 @default.
• W2095974206 countsByYear W20959742062014 @default.
• W2095974206 countsByYear W20959742062015 @default.
• W2095974206 countsByYear W20959742062016 @default.
• W2095974206 countsByYear W20959742062017 @default.
• W2095974206 countsByYear W20959742062018 @default.
• W2095974206 countsByYear W20959742062019 @default.
• W2095974206 countsByYear W20959742062020 @default.
• W2095974206 countsByYear W20959742062021 @default.
• W2095974206 countsByYear W20959742062022 @default.
• W2095974206 crossrefType "journal-article" @default.
• W2095974206 hasAuthorship W2095974206A5004343721 @default.
• W2095974206 hasAuthorship W2095974206A5007001229 @default.
• W2095974206 hasAuthorship W2095974206A5017098768 @default.
• W2095974206 hasAuthorship W2095974206A5022068141 @default.
• W2095974206 hasAuthorship W2095974206A5022101190 @default.
• W2095974206 hasAuthorship W2095974206A5034145989 @default.
• W2095974206 hasAuthorship W2095974206A5077723411 @default.
• W2095974206 hasAuthorship W2095974206A5080534060 @default.
• W2095974206 hasBestOaLocation W20959742061 @default.
• W2095974206 hasConcept C104317684 @default.
• W2095974206 hasConcept C134018914 @default.
• W2095974206 hasConcept C147483822 @default.
• W2095974206 hasConcept C203014093 @default.
• W2095974206 hasConcept C205260736 @default.
• W2095974206 hasConcept C2776393769 @default.
• W2095974206 hasConcept C2776946954 @default.
• W2095974206 hasConcept C2777863537 @default.
• W2095974206 hasConcept C2780801004 @default.
• W2095974206 hasConcept C55493867 @default.
• W2095974206 hasConcept C71924100 @default.
• W2095974206 hasConcept C86803240 @default.
• W2095974206 hasConcept C8891405 @default.

• next