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• W2095989717 abstract "Abstract Hyperinsulinemia and obesity-related metabolic disturbances are common and have been associated with increased cancer risk and poor prognosis. To investigate this issue in relation to prostate cancer, we conducted a nested case-control study within the Prostate Cancer Prevention Trial (PCPT), a randomized, placebo-controlled trial testing finasteride versus placebo for primary prevention of prostate cancer. Cases (n = 1,803) and controls (n = 1,797) were matched on age, PCPT treatment arm, and family history of prostate cancer; controls included all eligible non-whites. Baseline bloods were assayed for serum C-peptide (marker of insulin secretion) and leptin (an adipokine) using ELISA. All outcomes were biopsy determined. Logistic regression calculated odds ratios (OR) for total prostate cancer and polytomous logistic regression calculated ORs for low-grade (Gleason &lt;7) and high-grade (Gleason &gt;7) disease. Results were stratified by PCPT treatment arm for C-peptide. For men on placebo, higher versus lower serum C-peptide was associated with a nearly 2-fold increased risk of high-grade prostate cancer (Gleason &gt;7; multivariate-adjusted OR, 1.88; 95% confidence interval, 1.19–2.97; Ptrend = 0.004). When C-peptide was modeled as a continuous variable, every unit increase in log(C-peptide) resulted in a 39% increased risk of high-grade disease (P = 0.01). In contrast, there was no significant relationship between C-peptide and high-grade prostate cancer among men receiving finasteride. Leptin was not independently associated with high-grade prostate cancer. In conclusion, these results support findings from other observational studies that high serum C-peptide and insulin resistance, but not leptin, are associated with increased risk of high-grade prostate cancer. Our novel finding is that the C-peptide–associated risk was attenuated by use of finasteride. Cancer Prev Res; 3(3); 279–89" @default.
• W2095989717 created "2016-06-24" @default.
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• W2095989717 date "2010-03-01" @default.
• W2095989717 modified "2023-10-03" @default.
• W2095989717 title "Finasteride Modifies the Relation between Serum C-Peptide and Prostate Cancer Risk: Results from the Prostate Cancer Prevention Trial" @default.
• W2095989717 cites W1556469483 @default.
• W2095989717 cites W1572009433 @default.
• W2095989717 cites W1824186052 @default.
• W2095989717 cites W1902678347 @default.
• W2095989717 cites W1968143168 @default.
• W2095989717 cites W1970886812 @default.
• W2095989717 cites W1974031146 @default.
• W2095989717 cites W1974159970 @default.
• W2095989717 cites W1975924364 @default.
• W2095989717 cites W1977915186 @default.
• W2095989717 cites W1992930985 @default.
• W2095989717 cites W1993160802 @default.
• W2095989717 cites W1995152023 @default.
• W2095989717 cites W2000092136 @default.
• W2095989717 cites W2004766572 @default.
• W2095989717 cites W2012720027 @default.
• W2095989717 cites W2016130776 @default.
• W2095989717 cites W2029401897 @default.
• W2095989717 cites W2044826176 @default.
• W2095989717 cites W2049818544 @default.
• W2095989717 cites W2056965752 @default.
• W2095989717 cites W2064656431 @default.
• W2095989717 cites W2067096633 @default.
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• W2095989717 cites W2078190084 @default.
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• W2095989717 cites W2086247313 @default.
• W2095989717 cites W2089171551 @default.
• W2095989717 cites W2092841741 @default.
• W2095989717 cites W2098049779 @default.
• W2095989717 cites W2099168830 @default.
• W2095989717 cites W2099777151 @default.
• W2095989717 cites W2100408829 @default.
• W2095989717 cites W2100528017 @default.
• W2095989717 cites W2108747912 @default.
• W2095989717 cites W2112387917 @default.
• W2095989717 cites W2112776230 @default.
• W2095989717 cites W2113720631 @default.
• W2095989717 cites W2114024940 @default.
• W2095989717 cites W2114740540 @default.
• W2095989717 cites W2114919342 @default.
• W2095989717 cites W2115951150 @default.
• W2095989717 cites W2132522929 @default.
• W2095989717 cites W2141052372 @default.
• W2095989717 cites W2141662760 @default.
• W2095989717 cites W2141861192 @default.
• W2095989717 cites W2143501475 @default.
• W2095989717 cites W2144500191 @default.
• W2095989717 cites W2146419691 @default.
• W2095989717 cites W2147589302 @default.
• W2095989717 cites W2148002502 @default.
• W2095989717 cites W2154929552 @default.
• W2095989717 cites W2155243001 @default.
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• W2095989717 cites W2169214947 @default.
• W2095989717 cites W2169792318 @default.
• W2095989717 cites W2171294019 @default.
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• W2095989717 doi "https://doi.org/10.1158/1940-6207.capr-09-0188" @default.
• W2095989717 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3846551" @default.
• W2095989717 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20179296" @default.
• W2095989717 hasPublicationYear "2010" @default.
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