FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095993193> ?p ?o ?g. }

• W2095993193 endingPage "9104" @default.
• W2095993193 startingPage "9094" @default.
• W2095993193 abstract "In neurons, the Ca(2+)/calmodulin (CaM) kinase cascade transduces Ca(2+) signaling into gene transcription. The CaM kinase cascade is known to be important for brain development as well as memory formation in adult brain, although the functions of some cascade members remain unknown. Here we have generated null and hypomorphic mutants to study the physiological role of CaM kinase kinase alpha (CaMKKalpha), which phosphorylates and activates both CaM kinase I (CaMKI) and CaMKIV, the output kinases of the cascade. We show that CaMKKalpha is dispensable for brain development and long-term potentiation in adult hippocampal CA1 synapses. We find that CaMKKalpha is required for hippocampus-dependent contextual fear memory, but not spatial memory, formation. Surprisingly, CaMKKalpha is important for contextual fear memory formation in males but not in females. We show that in male mice, contextual fear conditioning induces up-regulation of hippocampal mRNA expression of brain-derived neurotrophic factor (BDNF) in a way that requires CaMKKalpha, while in female mice, contextual fear conditioning induces down-regulation of hippocampal BDNF mRNA expression that does not require CaMKKalpha. Additionally, we demonstrate sex-independent up-regulation in hippocampal nerve growth factor-inducible gene B mRNA expression that does not require CaMKKalpha. Thus, we show that CaMKKalpha has a specific complex role in memory formation in males." @default.
• W2095993193 created "2016-06-24" @default.
• W2095993193 creator A5041996180 @default.
• W2095993193 creator A5051896056 @default.
• W2095993193 creator A5061723479 @default.
• W2095993193 creator A5085793083 @default.
• W2095993193 creator A5086626216 @default.
• W2095993193 date "2006-12-01" @default.
• W2095993193 modified "2023-10-11" @default.
• W2095993193 title "Ca²⁺/Calmodulin Kinase Kinase α Is Dispensable for Brain Development but Is Required for Distinct Memories in Male, though Not in Female, Mice" @default.
• W2095993193 cites W1484384039 @default.
• W2095993193 cites W1532762518 @default.
• W2095993193 cites W1552458995 @default.
• W2095993193 cites W1588399796 @default.
• W2095993193 cites W1782908816 @default.
• W2095993193 cites W1952592959 @default.
• W2095993193 cites W1968735663 @default.
• W2095993193 cites W1972452740 @default.
• W2095993193 cites W1974976194 @default.
• W2095993193 cites W1981382840 @default.
• W2095993193 cites W1985239587 @default.
• W2095993193 cites W1985954147 @default.
• W2095993193 cites W1998669483 @default.
• W2095993193 cites W1998977808 @default.
• W2095993193 cites W2000685126 @default.
• W2095993193 cites W2002665203 @default.
• W2095993193 cites W2009728195 @default.
• W2095993193 cites W2020257412 @default.
• W2095993193 cites W2027120715 @default.
• W2095993193 cites W2031917138 @default.
• W2095993193 cites W2034764820 @default.
• W2095993193 cites W2046299324 @default.
• W2095993193 cites W2049134173 @default.
• W2095993193 cites W2052344839 @default.
• W2095993193 cites W2056155625 @default.
• W2095993193 cites W2061412811 @default.
• W2095993193 cites W2064641679 @default.
• W2095993193 cites W2068412840 @default.
• W2095993193 cites W2073192651 @default.
• W2095993193 cites W2079193109 @default.
• W2095993193 cites W2079355929 @default.
• W2095993193 cites W2088033659 @default.
• W2095993193 cites W2089609187 @default.
• W2095993193 cites W2089643893 @default.
• W2095993193 cites W2091077356 @default.
• W2095993193 cites W2091790691 @default.
• W2095993193 cites W2106787391 @default.
• W2095993193 cites W2125118099 @default.
• W2095993193 cites W2127673211 @default.
• W2095993193 cites W2133850147 @default.
• W2095993193 cites W2137932281 @default.
• W2095993193 cites W2148389554 @default.
• W2095993193 cites W2153949605 @default.
• W2095993193 cites W2160855812 @default.
• W2095993193 cites W2161711608 @default.
• W2095993193 cites W2164590669 @default.
• W2095993193 cites W2167194856 @default.
• W2095993193 cites W2340064264 @default.
• W2095993193 cites W4255975953 @default.
• W2095993193 doi "https://doi.org/10.1128/mcb.01221-06" @default.
• W2095993193 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1636825" @default.
• W2095993193 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17015468" @default.
• W2095993193 hasPublicationYear "2006" @default.
• W2095993193 type Work @default.
• W2095993193 sameAs 2095993193 @default.
• W2095993193 citedByCount "48" @default.
• W2095993193 countsByYear W20959931932012 @default.
• W2095993193 countsByYear W20959931932013 @default.
• W2095993193 countsByYear W20959931932014 @default.
• W2095993193 countsByYear W20959931932016 @default.
• W2095993193 countsByYear W20959931932017 @default.
• W2095993193 countsByYear W20959931932018 @default.
• W2095993193 countsByYear W20959931932019 @default.
• W2095993193 countsByYear W20959931932020 @default.
• W2095993193 countsByYear W20959931932021 @default.
• W2095993193 countsByYear W20959931932022 @default.
• W2095993193 crossrefType "journal-article" @default.
• W2095993193 hasAuthorship W2095993193A5041996180 @default.
• W2095993193 hasAuthorship W2095993193A5051896056 @default.
• W2095993193 hasAuthorship W2095993193A5061723479 @default.
• W2095993193 hasAuthorship W2095993193A5085793083 @default.
• W2095993193 hasAuthorship W2095993193A5086626216 @default.
• W2095993193 hasBestOaLocation W20959931932 @default.
• W2095993193 hasConcept C134018914 @default.
• W2095993193 hasConcept C148762608 @default.
• W2095993193 hasConcept C160539049 @default.
• W2095993193 hasConcept C169760540 @default.
• W2095993193 hasConcept C170493617 @default.
• W2095993193 hasConcept C181199279 @default.
• W2095993193 hasConcept C184235292 @default.
• W2095993193 hasConcept C25274449 @default.
• W2095993193 hasConcept C2778790584 @default.
• W2095993193 hasConcept C2781161787 @default.
• W2095993193 hasConcept C29688787 @default.
• W2095993193 hasConcept C54355233 @default.
• W2095993193 hasConcept C55493867 @default.
• W2095993193 hasConcept C86803240 @default.
• W2095993193 hasConcept C95444343 @default.

• next