Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095994503> ?p ?o ?g. }
- W2095994503 endingPage "134" @default.
- W2095994503 startingPage "126" @default.
- W2095994503 abstract "Riboflavin is a potent photosensitizer as well as part of the vitamin B complex. Recently we demonstrated that the products generated by irradiation of riboflavin have potential as anti-leukaemic therapy. The possible action, however, of the riboflavin photoproducts in solid cancers has not been addressed. Hence, we investigated the effects of irradiated riboflavin on androgen-independent human prostate cancer cells (PC3), a known model for solid tumour cells with an exceptional resistance to therapy. Our results show that riboflavin photoproducts are cytotoxic to these cells in a FasL–Fas-dependent manner. Furthermore, irradiated riboflavin inhibited matrix-degrading proteases, caused downregulation of VEGF and upregulation of TIMP1 suggesting anti-metastatic potential. Together, these results show that the anti-neoplastic action of riboflavin photoproducts is not limited to haematological malignancies, warranting clinical studies in solid tumours." @default.
- W2095994503 created "2016-06-24" @default.
- W2095994503 creator A5008299614 @default.
- W2095994503 creator A5014581818 @default.
- W2095994503 creator A5036853123 @default.
- W2095994503 creator A5040929636 @default.
- W2095994503 creator A5054400914 @default.
- W2095994503 creator A5067971176 @default.
- W2095994503 creator A5069908102 @default.
- W2095994503 creator A5072342063 @default.
- W2095994503 creator A5089826042 @default.
- W2095994503 date "2007-12-01" @default.
- W2095994503 modified "2023-10-08" @default.
- W2095994503 title "A possible anti-proliferative and anti-metastatic effect of irradiated riboflavin in solid tumours" @default.
- W2095994503 cites W1890066970 @default.
- W2095994503 cites W1967151168 @default.
- W2095994503 cites W1969158591 @default.
- W2095994503 cites W1969173749 @default.
- W2095994503 cites W1975497401 @default.
- W2095994503 cites W1992885568 @default.
- W2095994503 cites W2012127625 @default.
- W2095994503 cites W2014281089 @default.
- W2095994503 cites W2025047584 @default.
- W2095994503 cites W2048385870 @default.
- W2095994503 cites W2049088800 @default.
- W2095994503 cites W2050324116 @default.
- W2095994503 cites W2055401773 @default.
- W2095994503 cites W2057413658 @default.
- W2095994503 cites W2064033136 @default.
- W2095994503 cites W2069601913 @default.
- W2095994503 cites W2071116121 @default.
- W2095994503 cites W2073096708 @default.
- W2095994503 cites W2079962068 @default.
- W2095994503 cites W2098839794 @default.
- W2095994503 cites W2102253975 @default.
- W2095994503 cites W2104762821 @default.
- W2095994503 cites W2108852443 @default.
- W2095994503 cites W2110069428 @default.
- W2095994503 cites W2114918609 @default.
- W2095994503 cites W2120262606 @default.
- W2095994503 cites W2156279401 @default.
- W2095994503 cites W2156685281 @default.
- W2095994503 cites W2156892356 @default.
- W2095994503 cites W2171466904 @default.
- W2095994503 doi "https://doi.org/10.1016/j.canlet.2007.08.024" @default.
- W2095994503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17933458" @default.
- W2095994503 hasPublicationYear "2007" @default.
- W2095994503 type Work @default.
- W2095994503 sameAs 2095994503 @default.
- W2095994503 citedByCount "44" @default.
- W2095994503 countsByYear W20959945032012 @default.
- W2095994503 countsByYear W20959945032013 @default.
- W2095994503 countsByYear W20959945032014 @default.
- W2095994503 countsByYear W20959945032015 @default.
- W2095994503 countsByYear W20959945032016 @default.
- W2095994503 countsByYear W20959945032017 @default.
- W2095994503 countsByYear W20959945032018 @default.
- W2095994503 countsByYear W20959945032019 @default.
- W2095994503 countsByYear W20959945032020 @default.
- W2095994503 countsByYear W20959945032021 @default.
- W2095994503 countsByYear W20959945032023 @default.
- W2095994503 crossrefType "journal-article" @default.
- W2095994503 hasAuthorship W2095994503A5008299614 @default.
- W2095994503 hasAuthorship W2095994503A5014581818 @default.
- W2095994503 hasAuthorship W2095994503A5036853123 @default.
- W2095994503 hasAuthorship W2095994503A5040929636 @default.
- W2095994503 hasAuthorship W2095994503A5054400914 @default.
- W2095994503 hasAuthorship W2095994503A5067971176 @default.
- W2095994503 hasAuthorship W2095994503A5069908102 @default.
- W2095994503 hasAuthorship W2095994503A5072342063 @default.
- W2095994503 hasAuthorship W2095994503A5089826042 @default.
- W2095994503 hasConcept C104317684 @default.
- W2095994503 hasConcept C127561419 @default.
- W2095994503 hasConcept C178790620 @default.
- W2095994503 hasConcept C185592680 @default.
- W2095994503 hasConcept C2776155809 @default.
- W2095994503 hasConcept C2781469039 @default.
- W2095994503 hasConcept C502942594 @default.
- W2095994503 hasConcept C55493867 @default.
- W2095994503 hasConcept C86803240 @default.
- W2095994503 hasConceptScore W2095994503C104317684 @default.
- W2095994503 hasConceptScore W2095994503C127561419 @default.
- W2095994503 hasConceptScore W2095994503C178790620 @default.
- W2095994503 hasConceptScore W2095994503C185592680 @default.
- W2095994503 hasConceptScore W2095994503C2776155809 @default.
- W2095994503 hasConceptScore W2095994503C2781469039 @default.
- W2095994503 hasConceptScore W2095994503C502942594 @default.
- W2095994503 hasConceptScore W2095994503C55493867 @default.
- W2095994503 hasConceptScore W2095994503C86803240 @default.
- W2095994503 hasIssue "1" @default.
- W2095994503 hasLocation W20959945031 @default.
- W2095994503 hasLocation W20959945032 @default.
- W2095994503 hasOpenAccess W2095994503 @default.
- W2095994503 hasPrimaryLocation W20959945031 @default.
- W2095994503 hasRelatedWork W1501164736 @default.
- W2095994503 hasRelatedWork W1665322839 @default.
- W2095994503 hasRelatedWork W2044510317 @default.
- W2095994503 hasRelatedWork W2082860237 @default.