FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095998520> ?p ?o ?g. }

• W2095998520 endingPage "245" @default.
• W2095998520 startingPage "236" @default.
• W2095998520 abstract "Peritoneal-and pulmonary macrophages can be activated in vitro with lymphokines (LK) or IFN-gamma, without exogenous lipopolysaccharide, for fungicidal activity against several pathogenic fungi. However, neither the biochemical nor metabolic events of the activation process or of the effector phase have been defined. In the present work we sought to elucidate these events with time-course studies using inhibitors of protein synthesis as well as immunosuppressive agents. We found that protein synthesis inhibitors abrogated the activation process, because cycloheximide (CHX) (1-2 micrograms/ml) prevented activation of macrophages for fungicidal activity against Candida albicans, Blastomyces dermatitidis, and Paracoccidioides brasiliensis. Blocking of the activation process by CHX was not due to macrophage cytotoxicity, and CHX did not impair the ability of nonactivated macrophages to kill Candida parapsilosis. In kinetic studies we showed that activation of macrophages was induced in 4 hr of LK treatment and that CHX had no effect if added after this time. In contrast to CHX, therapeutic concentrations of hydrocortisone (HC), such as less than or equal to 5 micrograms/ml, or cyclosporin A (CsA), 5 micrograms/ml, did not significantly inhibit LK activation of macrophages for killing of fungi. In the effector phase, the fungicidal capacity of activated macrophages in short-term (less than or equal to 4 hr) killing assays could not be abrogated by CHX (5 micrograms/ml), HC (100 micrograms/ml), or CsA (10 micrograms/ml). These results demonstrate that the activation but not the effector mechanism of macrophages for fungicidal activity is blocked by inhibition of protein synthesis. In contrast, therapeutic concentrations of HC or CsA may not interfere with activation of macrophages or their killing mechanisms, thus providing a rationale for antifungal immunotherapy in certain clinical situations (e.g., infection in the immunosuppressed patient)." @default.
• W2095998520 created "2016-06-24" @default.
• W2095998520 creator A5009082087 @default.
• W2095998520 creator A5021143803 @default.
• W2095998520 creator A5081343682 @default.
• W2095998520 date "1991-01-01" @default.
• W2095998520 modified "2023-09-25" @default.
• W2095998520 title "Kinetics and requirements for activation of macrophages for fungicidal activity: Effect of protein synthesis inhibitors and immunosuppressants on activation and fungicidal mechanism" @default.
• W2095998520 cites W1482499231 @default.
• W2095998520 cites W1512648700 @default.
• W2095998520 cites W1512806851 @default.
• W2095998520 cites W1603971421 @default.
• W2095998520 cites W1643772983 @default.
• W2095998520 cites W1816400361 @default.
• W2095998520 cites W1903498165 @default.
• W2095998520 cites W1912782953 @default.
• W2095998520 cites W1966616589 @default.
• W2095998520 cites W1977924342 @default.
• W2095998520 cites W2037319487 @default.
• W2095998520 cites W2056234608 @default.
• W2095998520 cites W2068598791 @default.
• W2095998520 cites W2070479570 @default.
• W2095998520 cites W2106628062 @default.
• W2095998520 cites W2110026699 @default.
• W2095998520 cites W2114582717 @default.
• W2095998520 cites W2116842602 @default.
• W2095998520 cites W2122741517 @default.
• W2095998520 cites W2132591086 @default.
• W2095998520 cites W2165776283 @default.
• W2095998520 cites W2168891026 @default.
• W2095998520 cites W2267516419 @default.
• W2095998520 cites W2336471646 @default.
• W2095998520 cites W2417771795 @default.
• W2095998520 cites W4210809420 @default.
• W2095998520 cites W4366067776 @default.
• W2095998520 doi "https://doi.org/10.1016/0008-8749(91)90022-4" @default.
• W2095998520 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1712253" @default.
• W2095998520 hasPublicationYear "1991" @default.
• W2095998520 type Work @default.
• W2095998520 sameAs 2095998520 @default.
• W2095998520 citedByCount "19" @default.
• W2095998520 countsByYear W20959985202012 @default.
• W2095998520 countsByYear W20959985202014 @default.
• W2095998520 crossrefType "journal-article" @default.
• W2095998520 hasAuthorship W2095998520A5009082087 @default.
• W2095998520 hasAuthorship W2095998520A5021143803 @default.
• W2095998520 hasAuthorship W2095998520A5081343682 @default.
• W2095998520 hasConcept C109316439 @default.
• W2095998520 hasConcept C202751555 @default.
• W2095998520 hasConcept C203014093 @default.
• W2095998520 hasConcept C2778128677 @default.
• W2095998520 hasConcept C2778754761 @default.
• W2095998520 hasConcept C2779244956 @default.
• W2095998520 hasConcept C2780917455 @default.
• W2095998520 hasConcept C2781363766 @default.
• W2095998520 hasConcept C3675279 @default.
• W2095998520 hasConcept C49382859 @default.
• W2095998520 hasConcept C51785407 @default.
• W2095998520 hasConcept C55493867 @default.
• W2095998520 hasConcept C86803240 @default.
• W2095998520 hasConcept C89423630 @default.
• W2095998520 hasConcept C98274493 @default.
• W2095998520 hasConceptScore W2095998520C109316439 @default.
• W2095998520 hasConceptScore W2095998520C202751555 @default.
• W2095998520 hasConceptScore W2095998520C203014093 @default.
• W2095998520 hasConceptScore W2095998520C2778128677 @default.
• W2095998520 hasConceptScore W2095998520C2778754761 @default.
• W2095998520 hasConceptScore W2095998520C2779244956 @default.
• W2095998520 hasConceptScore W2095998520C2780917455 @default.
• W2095998520 hasConceptScore W2095998520C2781363766 @default.
• W2095998520 hasConceptScore W2095998520C3675279 @default.
• W2095998520 hasConceptScore W2095998520C49382859 @default.
• W2095998520 hasConceptScore W2095998520C51785407 @default.
• W2095998520 hasConceptScore W2095998520C55493867 @default.
• W2095998520 hasConceptScore W2095998520C86803240 @default.
• W2095998520 hasConceptScore W2095998520C89423630 @default.
• W2095998520 hasConceptScore W2095998520C98274493 @default.
• W2095998520 hasIssue "1" @default.
• W2095998520 hasLocation W20959985201 @default.
• W2095998520 hasLocation W20959985202 @default.
• W2095998520 hasOpenAccess W2095998520 @default.
• W2095998520 hasPrimaryLocation W20959985201 @default.
• W2095998520 hasRelatedWork W1631094551 @default.
• W2095998520 hasRelatedWork W1926631416 @default.
• W2095998520 hasRelatedWork W1927895486 @default.
• W2095998520 hasRelatedWork W2021124811 @default.
• W2095998520 hasRelatedWork W2053031032 @default.
• W2095998520 hasRelatedWork W2095998520 @default.
• W2095998520 hasRelatedWork W2162532891 @default.
• W2095998520 hasRelatedWork W2391667170 @default.
• W2095998520 hasRelatedWork W2701404672 @default.
• W2095998520 hasRelatedWork W1986075224 @default.
• W2095998520 hasVolume "132" @default.
• W2095998520 isParatext "false" @default.
• W2095998520 isRetracted "false" @default.
• W2095998520 magId "2095998520" @default.
• W2095998520 workType "article" @default.