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• W2096004952 abstract "Evolution or engineering of novel metabolic pathways can endow microbes with new abilities to degrade anthropogenic pollutants or synthesize valuable chemicals. Most studies of the evolution of new pathways have focused on the origins and quality of function of the enzymes involved. However, there is an additional layer of complexity that has received less attention. Introduction of a novel pathway into an existing metabolic network can result in inhibitory cross-talk due to adventitious interactions between metabolites and macromolecules that have not previously encountered one another. Here, we report a thorough examination of inhibitory cross-talk between a novel metabolic pathway for synthesis of pyridoxal 5'-phosphate and the existing metabolic network of Escherichia coli. We demonstrate multiple problematic interactions, including (i) interference by metabolites in the novel pathway with metabolic processes in the existing network, (ii) interference by metabolites in the existing network with the function of the novel pathway, and (iii) diversion of metabolites from the novel pathway by promiscuous activities of enzymes in the existing metabolic network. Identification of the mechanisms of inhibitory cross-talk can reveal the types of adaptations that must occur to enhance the performance of a novel metabolic pathway as well as the fitness of the microbial host. These findings have important implications for evolutionary studies of the emergence of novel pathways in nature as well as genetic engineering of microbes for green manufacturing processes." @default.
• W2096004952 created "2016-06-24" @default.
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• W2096004952 date "2012-09-14" @default.
• W2096004952 modified "2023-10-01" @default.
• W2096004952 title "Inhibitory cross-talk upon introduction of a new metabolic pathway into an existing metabolic network" @default.
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• W2096004952 doi "https://doi.org/10.1073/pnas.1208509109" @default.
• W2096004952 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3479479" @default.
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